Showing BioInteractions for Droxidopa (DB06262)
BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Droxidopa is a Phenylalanine-4-hydroxylase inhibitor | ||
| 1 | Phenylalanine-4-hydroxylase cofactors | Sapropterin |
| 2 | Phenylalanine-4-hydroxylase inhibitors | Norepinephrine |
| 3 | Phenylalanine-4-hydroxylase inducers | Cupric sulfate |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Droxidopa is a Alpha-1B adrenergic receptor agonist | ||
| 1 | Alpha-1B adrenergic receptor antagonists | Acepromazine, Alfuzosin, Amitriptyline, Aripiprazole, Aripiprazole lauroxil, Brexpiprazole, Bromocriptine, Carvedilol, Chlorpromazine, Clozapine, Dapiprazole, Dextroamphetamine, Doxepin, Dronedarone, Imipramine, Methotrimeprazine, Nicardipine, Nortriptyline, Olanzapine, Paliperidone, Periciazine, Phenoxybenzamine, Phentolamine, Pizotifen, Prazosin, Quinidine, Risperidone, Silodosin, Tamsulosin, Terazosin, Thioproperazine, Thioridazine, Trimipramine, Verapamil, Ziprasidone |
| 2 | Alpha-1B adrenergic receptor partial agonists | Cirazoline, Ergotamine, Modafinil |
| 3 | Alpha-1B adrenergic receptor agonists | Bromocriptine, Clonidine, Epinephrine, Methoxamine, Midodrine, Norepinephrine, Oxymetazoline, Pergolide, Phendimetrazine, Phenylephrine, Racepinephrine, Xylometazoline |
| 4 | Alpha-1B adrenergic receptor binders | Cabergoline, Loxapine |
| 5 | Alpha-1B adrenergic receptor inhibitors | Fenoldopam |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Droxidopa is a Alpha-1D adrenergic receptor agonist | ||
| 1 | Alpha-1D adrenergic receptor antagonists | Alfuzosin, Amitriptyline, Carvedilol, Dapiprazole, Doxazosin, Doxepin, Dronedarone, Epinephrine, Imipramine, Methotrimeprazine, Nicardipine, Nortriptyline, Phenoxybenzamine, Phentolamine, Pizotifen, Prazosin, Quinidine, Racepinephrine, Silodosin, Tamsulosin, Terazosin, Verapamil |
| 2 | Alpha-1D adrenergic receptor agonists | Bromocriptine, Clonidine, Midodrine, Norepinephrine, Oxymetazoline, Pergolide, Phenylephrine, Xylometazoline |
| 3 | Alpha-1D adrenergic receptor partial agonists | Cirazoline, Ergotamine |
| 4 | Alpha-1D adrenergic receptor inhibitors | Fenoldopam |
| 5 | Alpha-1D adrenergic receptor binders | Cabergoline, Methoxamine |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Droxidopa is a Alpha-2B adrenergic receptor agonist | ||
| 1 | Alpha-2B adrenergic receptor antagonists | Aripiprazole, Asenapine, Cabergoline, Carvedilol, Celiprolol, Clozapine, Dronedarone, Fenoldopam, Methotrimeprazine, Mianserin, Paliperidone, Phenoxybenzamine, Pizotifen, Quetiapine, Risperidone, Rotigotine, Yohimbine, Ziprasidone |
| 2 | Alpha-2B adrenergic receptor agonists | Apomorphine, Apraclonidine, Brimonidine, Bromocriptine, Clonidine, Ephedra sinica root, Epinephrine, Etomidate, Metamfetamine, Norepinephrine, Oxymetazoline, Racepinephrine, Xylometazoline |
| 3 | Alpha-2B adrenergic receptor ligands | Aripiprazole |
| 4 | Alpha-2B adrenergic receptor binders | Guanabenz, Guanfacine, Loxapine, Prazosin, Tolazoline |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Droxidopa is a Alpha-2C adrenergic receptor agonist | ||
| 1 | Alpha-2C adrenergic receptor antagonists | Aripiprazole, Asenapine, Brexpiprazole, Cabergoline, Carvedilol, Celiprolol, Clozapine, Dronedarone, Fenoldopam, Iloperidone, Lurasidone, Methotrimeprazine, Mianserin, Phenoxybenzamine, Pizotifen, Quetiapine, Risperidone, Yohimbine, Ziprasidone |
| 2 | Alpha-2C adrenergic receptor agonists | Agmatine, Apomorphine, Brimonidine, Bromocriptine, Clonidine, Ephedra sinica root, Metamfetamine, Norepinephrine, Oxymetazoline, Paliperidone, Racepinephrine, Xylometazoline |
| 3 | Alpha-2C adrenergic receptor binders | Loxapine, Tolazoline |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Droxidopa is a Beta-3 adrenergic receptor agonist | ||
| 1 | Beta-3 adrenergic receptor agonists | Arbutamine, Celiprolol, Clenbuterol, Ephedra sinica root, Fenoterol, Formoterol, Isoprenaline, Mirabegron, Nebivolol, Norepinephrine, Pindolol, Racepinephrine, Solabegron, Terbutaline, Vibegron |
| 2 | Beta-3 adrenergic receptor antagonists | Alprenolol, Bupranolol, Propranolol |
| 3 | Beta-3 adrenergic receptor inverse agonists | Salmeterol |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Droxidopa is a Aromatic-L-amino-acid decarboxylase substrate | ||
| 1 | Aromatic-L-amino-acid decarboxylase cofactors | Pyridoxal phosphate |
| 2 | Aromatic-L-amino-acid decarboxylase inhibitors | Benserazide, Carbidopa, Cycloserine, Methyldopa |
| 3 | Aromatic-L-amino-acid decarboxylase substrates | Fluorodopa (18F), Levodopa, Tryptophan |
| 4 | Aromatic-L-amino-acid decarboxylase inducers | Amantadine, Flupentixol |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Droxidopa is a Monocarboxylate transporter 10 inhibitor | ||
| 1 | Monocarboxylate transporter 10 inhibitors | Alanine, Arginine, Asparagine, Aspartic acid, Cysteine, Cystine, D-Alanine, D-Leucine, D-Phenylalanine, D-Serine, D-Tryptophan, D-Tyrosine, Glutamic acid, Glycine, Histidine, Isoleucine, L-Glutamine, Lactic acid, Leucine, Levodopa, Liothyronine, Liotrix, Lysine, Methionine, Phenylalanine, Proline, Pyruvic acid, Serine, Threonine, Tryptophan, Tyrosine, Valine |
| 2 | Monocarboxylate transporter 10 substrates | 2-aminoisobutyric acid, beta-Alanine, D-Phenylalanine, Glutamic acid, Glycine, Histidine, Lactic acid, Lysine, Pyruvic acid |