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Identification
NameNitrous oxide
Accession NumberDB06690
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

Nitrous oxide, commonly known as “laughing gas”, is a chemical compound with the chemical formula N2O. At room temperature, it is a colorless non-flammable gas, with a pleasant, slightly sweet odor and taste. It is used in surgery and dentistry for its anesthetic and analgesic effects. It is known as “laughing gas” due to the euphoric effects of inhaling it, a property that has led to its recreational use as an inhalant drug [Wikipedia].

Structure
Thumb
Synonyms
Nitrious oxide
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Air Supply Of North Texas2009-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Argyle Welding Supply Company, Inc.1974-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Air Source Industries Inc1992-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Air Liquide America Specialty Gases LLC1960-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Air Liquide Healthcare America Corporation1960-01-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Metro Welding Supply Corporation2015-03-17Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)American Welding & Gas2014-05-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Industrial Gas Distributors Inc2002-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Norco, Inc2008-09-01Not applicableUs
Nitrous Oxidegas99 kg/100kgrespiratory (inhalation)Holston Gases, Inc1958-01-01Not applicableUs
Nitrous Oxideliquid99 L/100Lrespiratory (inhalation)Air Liquide America Specialty Gases LLC1960-01-01Not applicableUs
Nitrous Oxidegas98 %inhalationMatheson Gas Products Canada Inc.1988-09-271997-12-24Canada
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Nitrous Oxide1900-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Air Liquide America Specialty Gases LLC1960-01-01Not applicableUs
Nitrous Oxidegas992 mL/Lrespiratory (inhalation)Red Ball Oxygen Co., Inc.1986-01-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Scott Gross Company, Inc.1974-12-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Oxarc, Inc.1977-01-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Central Welding Supply Company2016-03-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Nex Air, Llc1996-06-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Du Puy Oxygen & Supply Company, Inc.1954-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Airtec Gases, Llc2004-01-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)AGL Inhalation Therapy Co.1966-01-01Not applicableUs
Nitrous Oxideliquid99 L/100Lrespiratory (inhalation)Air Liquide Healthcare America Corporation1960-01-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Machine & Welding Supply Company1999-06-15Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Badger Welding Supplies, Inc1955-01-01Not applicableUs
Nitrous Oxide 100%gas100 %inhalationAir Liquide Canada Inc.1911-12-31Not applicableCanada
Nitrous Oxide 99%gas99 %inhalationAir Products Canada Ltd/LtÉe.1983-12-312003-06-13Canada
Nitrous Oxide USPgas99 %Liquid Carbonic Inc.1968-12-311998-06-09Canada
Nitrous Oxide USP 99%gas99 %inhalationPraxair Canada Inc1993-12-31Not applicableCanada
Nitrous Oxide, USPgas99 %inhalationLinde Canada Limited1995-12-31Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nitrous Oxidegas992 mL/Lrespiratory (inhalation)Airgas Intermountain Inc1985-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Blue Water Industrial Products, Inc.2008-12-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Linde Gas North America LLC1986-06-16Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Acetylene Oxygen Company1936-01-01Not applicableUs
Nitrous Oxidegas992 mL/Lrespiratory (inhalation)Airgas Nor Pac Inc1983-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Capweld Inc1952-01-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Roberts Oxygen Company, Inc.1967-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Argyle Welding Supply Co. Inc.1974-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Linde Gas North America LLC1990-11-27Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Lessors, Incorporated1964-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Crumpton Welding Supply & Equipment, Inc1990-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Fullerton Welding Supply2008-02-06Not applicableUs
Nitrous Oxidegas995 mL/Lrespiratory (inhalation)General Air Service & Supply Co1976-11-01Not applicableUs
Nitrous Oxidegas99 kg/100kgrespiratory (inhalation)Holston Gases, Inc1958-01-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)ILMO Products Company1995-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Compressed Gases Inc1980-01-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)General Welding Supply Corp.1984-01-01Not applicableUs
Nitrous Oxidegas992 mL/Lrespiratory (inhalation)Matheson Tri Gas, Inc.1987-01-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Praxair Distribution Southeast LLC2007-10-01Not applicableUs
Nitrous Oxideliquid99 L/100Lrespiratory (inhalation)Welding & Therapy Service Inc.1971-11-01Not applicableUs
Nitrous Oxidegas995 mL/Lrespiratory (inhalation)Inland Welding Supply Dba A L Compressed Gases2005-07-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)ABCO Welding and Industrial Supply Inc.2010-05-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Strate Welding Supply Co., Inc.1949-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Welding & Therapy Service, Inc1971-11-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Purity Cylinder Gases Inc1938-10-20Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Nordan Smith Welding Supply1995-01-04Not applicableUs
Nitrous Oxidegas990 mL/LrectalEncompass Medical & Specialty Gases, Ltd.2008-01-02Not applicableUs
Nitrous Oxidegas99 mL/Lrespiratory (inhalation)Boggs Gases Div. Boggs Fire Equipment1995-09-28Not applicableUs
Nitrous Oxidegas99 kg/100kgrespiratory (inhalation)United States Welding, Inc.1970-01-01Not applicableUs
Nitrous Oxidegas99 L/100Lrespiratory (inhalation)Keen Compressed Gas Co. Inc.1919-01-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Praxair Distribution, Inc.2007-10-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Airgas East, Inc.1991-01-15Not applicableUs
Nitrous Oxidegas992 mL/Lrespiratory (inhalation)Airgas West, Inc.1947-05-23Not applicableUs
Nitrous Oxidegas995 mL/Lrespiratory (inhalation)West Air Gases & Equipment, Inc.2000-01-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Roberts Oxygen Company, Inc.1967-01-01Not applicableUs
Nitrous Oxidegas992 mL/Lrespiratory (inhalation)Airgas Northern California And Nevada, Inc.1965-01-01Not applicableUs
Nitrous Oxidegas990 mL/Lrespiratory (inhalation)Aero All Gas Company1972-10-06Not applicableUs
Nitrous Oxide Sedaragas990 mL/Lrespiratory (inhalation)Linde Gas North America LLC2012-06-18Not applicableUs
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Alnox GasAir Liquide Canada Inc.
EntonoxLinde Canada Limited
Liqui-med Analgesic GasPraxair Canada Inc
Nitrous Oxide In OxygenMatheson Gas Products Canada Inc.
SaltsNot Available
Categories
UNIIK50XQU1029
CAS number10024-97-2
WeightAverage: 44.0128
Monoisotopic: 44.001062632
Chemical FormulaN2O
InChI KeyInChIKey=GQPLMRYTRLFLPF-UHFFFAOYSA-N
InChI
InChI=1S/N2O/c1-2-3
IUPAC Name
diazooxidane
SMILES
[O-][N+]#N
Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other nonmetals'.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassHomogeneous other non-metal compounds
Sub ClassNot Available
Direct ParentHomogeneous other non-metal compounds
Alternative Parents
Substituents
  • Homogeneous other non metal
  • Inorganic oxide
  • Acyclic compound
Molecular FrameworkAcyclic compounds
External Descriptors
Pharmacology
IndicationNot Available
PharmacodynamicsNot Available
Mechanism of actionFindings to date indicate that nitrous oxide induces opioid peptide release in the brain stem leading to the activation of descending noradrenergic neurones, which results in modulation of the nociceptive process in the spinal cord. Several receptor–effector mechanisms including dopamine receptors, α2 adrenoceptors, benzodiazepine receptors and -methyl- -aspartate (NMDA) receptors have been implicated although the relationship of one with the other is not known.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9467
Blood Brain Barrier+0.9872
Caco-2 permeable+0.5561
P-glycoprotein substrateNon-substrate0.9009
P-glycoprotein inhibitor INon-inhibitor0.9747
P-glycoprotein inhibitor IINon-inhibitor0.9944
Renal organic cation transporterNon-inhibitor0.9407
CYP450 2C9 substrateNon-substrate0.8867
CYP450 2D6 substrateNon-substrate0.8789
CYP450 3A4 substrateNon-substrate0.7447
CYP450 1A2 substrateNon-inhibitor0.7496
CYP450 2C9 inhibitorNon-inhibitor0.9074
CYP450 2D6 inhibitorNon-inhibitor0.9293
CYP450 2C19 inhibitorNon-inhibitor0.9089
CYP450 3A4 inhibitorNon-inhibitor0.9871
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9435
Ames testAMES toxic0.7381
CarcinogenicityCarcinogens 0.6906
BiodegradationReady biodegradable0.9704
Rat acute toxicity2.8320 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8497
hERG inhibition (predictor II)Non-inhibitor0.971
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Gasinhalation
Gasinhalation98 %
Gasrectal990 mL/L
Gasrespiratory (inhalation)99 L/100L
Gasrespiratory (inhalation)99 mL/L
Gasrespiratory (inhalation)99 kg/100kg
Gasrespiratory (inhalation)990 mL/L
Gasrespiratory (inhalation)992 mL/L
Gasrespiratory (inhalation)995 mL/L
Liquidrespiratory (inhalation)99 L/100L
Gasinhalation100 %
Gas99 %
Gasinhalation99 %
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point-90.81 °CPhysProp
boiling point-88.46 °CPhysProp
logP0.36HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
logP-0.021ChemAxon
pKa (Strongest Basic)-6.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area54.46 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity27.67 m3·mol-1ChemAxon
Polarizability2.54 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0002-9000000000-2eee7435817186856ef7View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001j-9000000000-d1a5381e3dd214cad7abView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000t-9000000000-3ae2e01e3d626729760bView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-004l-9000000000-c53ff0d270e0310b3375View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9000000000-c8b9d8f80d3f41ad7f54View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-002f-9000000000-12c3fe456373daff732eView in MoNA
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesN01AX13N01AX63
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
AzelastineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Nitrous oxide.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
BuprenorphineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
EthanolNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
HydrocodoneNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nitrous oxide.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
MethotrimeprazineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MetyrosineNitrous oxide may increase the sedative activities of Metyrosine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
MirtazapineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
OrphenadrineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
ParaldehydeNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Paroxetine.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
PramipexoleNitrous oxide may increase the sedative activities of Pramipexole.
RopiniroleNitrous oxide may increase the sedative activities of Ropinirole.
RotigotineNitrous oxide may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Nitrous oxide.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
SuvorexantNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
ThalidomideNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ZolpidemNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Food InteractionsNot Available
Comments
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Drug created on September 02, 2008 09:56 / Updated on November 26, 2015 17:13