NAV

Sulfameter

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Sulfameter
DrugBank Accession Number
DB06821
Background

Long acting sulfonamide used in leprosy, urinary, and respiratory tract infections.

Type
Small Molecule
Groups
Approved
Structure
3D
Similar Structures
Weight
Average: 280.3
Monoisotopic: 280.063011436
Chemical Formula
C11H12N4O3S
Synonyms
  • Sulfa-5-methoxypyrimidine
  • Sulfameter
  • Sulfamethoxydiazine
  • Sulfametoxidiazina
  • Sulfametoxydiazine
  • Sulfametoxydiazinum
External IDs
  • AHR-857
  • BAY-5400
  • Bayer 5400
  • I-2586
  • NSC-683528
  • SH 613
  • SH-613
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
ADihydropteroate synthase
inhibitor
Escherichia coli (strain K12)
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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interactions in your software
AcarboseThe therapeutic efficacy of Acarbose can be increased when used in combination with Sulfameter.
AcenocoumarolThe risk or severity of bleeding can be increased when Sulfameter is combined with Acenocoumarol.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be increased when used in combination with Sulfameter.
AlbiglutideThe therapeutic efficacy of Albiglutide can be increased when used in combination with Sulfameter.
AlogliptinThe therapeutic efficacy of Alogliptin can be increased when used in combination with Sulfameter.
Food Interactions
Not Available

Categories

ATC Codes
J01ED04 — SulfametoxydiazineG01AE10 — Combinations of sulfonamides
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzenesulfonamides
Direct Parent
Aminobenzenesulfonamides
Alternative Parents
Benzenesulfonyl compounds / Aniline and substituted anilines / Alkyl aryl ethers / Pyrimidines and pyrimidine derivatives / Organosulfonamides / Heteroaromatic compounds / Aminosulfonyl compounds / Azacyclic compounds / Primary amines / Organopnictogen compounds
show 2 more
Substituents
Alkyl aryl ether / Amine / Aminobenzenesulfonamide / Aminosulfonyl compound / Aniline or substituted anilines / Aromatic heteromonocyclic compound / Azacycle / Benzenesulfonyl group / Ether / Heteroaromatic compound
show 15 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
sulfonamide, pyrimidines, sulfonamide antibiotic (CHEBI:53727)
Affected organisms
Not Available

Chemical Identifiers

UNII
3L179F09D6
CAS number
651-06-9
InChI Key
GPTONYMQFTZPKC-UHFFFAOYSA-N
InChI
InChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
IUPAC Name
4-amino-N-(5-methoxypyrimidin-2-yl)benzene-1-sulfonamide
SMILES
COC1=CN=C(NS(=O)(=O)C2=CC=C(N)C=C2)N=C1

References

General References
Not Available
KEGG Drug
D02517
ChemSpider
5135
ChEBI
53727
ChEMBL
CHEMBL1200359
ZINC
ZINC000000049142
Wikipedia
Sulfametoxydiazine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.313 mg/mLALOGPS
logP0.53ALOGPS
logP0.23Chemaxon
logS-3ALOGPS
pKa (Strongest Acidic)7.06Chemaxon
pKa (Strongest Basic)1.98Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area107.2 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity70.66 m3·mol-1Chemaxon
Polarizability26.24 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSsplash10-0a4i-3910000000-3c257f14a64853993a15
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0a4i-2960000000-d6c60ed2edc574dfcb49
MS/MS Spectrum - , positiveLC-MS/MSsplash10-001i-1590000000-97a9d57c56fb271fc603
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4i-3910000000-3c257f14a64853993a15
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-0290000000-10f30e48bccf3829a90e
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-0940000000-395492bbef6683299a21
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-0490000000-eea78ecf915ac7bdd086
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-02dl-9480000000-e8e0052ce0795969a169
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-052b-0900000000-dadfe97c407885fbf616
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0005-4900000000-95c0b2a757e38ab210fc
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-177.8524009
predicted
DarkChem Lite v0.1.0
[M-H]-163.49217
predicted
DeepCCS 1.0 (2019)
[M+H]+179.2731009
predicted
DarkChem Lite v0.1.0
[M+H]+165.85016
predicted
DeepCCS 1.0 (2019)
[M+Na]+178.1051009
predicted
DarkChem Lite v0.1.0
[M+Na]+171.9433
predicted
DeepCCS 1.0 (2019)

Targets

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Details1. Dihydropteroate synthase
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Yes
Actions
Inhibitor
General Function
Metal ion binding
Specific Function
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Gene Name
folP
Uniprot ID
P0AC13
Uniprot Name
Dihydropteroate synthase
Molecular Weight
30614.855 Da
References
  1. Noutoshi Y, Ikeda M, Saito T, Osada H, Shirasu K: Sulfonamides identified as plant immune-priming compounds in high-throughput chemical screening increase disease resistance in Arabidopsis thaliana. Front Plant Sci. 2012 Oct 31;3:245. doi: 10.3389/fpls.2012.00245. eCollection 2012. [Article]

Drug created at September 14, 2010 16:21 / Updated at February 21, 2021 18:52