1-Naphthyl-L-alanine
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Identification
- Generic Name
- 1-Naphthyl-L-alanine
- DrugBank Accession Number
- DB07365
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 215.2478
Monoisotopic: 215.094628665 - Chemical Formula
- C13H13NO2
- Synonyms
- (S)-2-Amino-3-(naphthalen-1-yl)propanoic acid
- L-beta-(1-Naphthyl)alanine
- Naphthalen-2-yl-3-alanine
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UPeriplasmic oligopeptide-binding protein Not Available Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) UPol polyprotein Not Available FIV - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Naphthalenes
- Sub Class
- Not Available
- Direct Parent
- Naphthalenes
- Alternative Parents
- L-alpha-amino acids / Aralkylamines / Amino acids / Monocarboxylic acids and derivatives / Carboxylic acids / Organopnictogen compounds / Organic oxides / Monoalkylamines / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Alpha-amino acid / Alpha-amino acid or derivatives / Amine / Amino acid / Amino acid or derivatives / Aralkylamine / Aromatic homopolycyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid derivative
- Molecular Framework
- Aromatic homopolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 9G930UL92R
- CAS number
- 55516-54-6
- InChI Key
- OFYAYGJCPXRNBL-LBPRGKRZSA-N
- InChI
- InChI=1S/C13H13NO2/c14-12(13(15)16)8-10-6-3-5-9-4-1-2-7-11(9)10/h1-7,12H,8,14H2,(H,15,16)/t12-/m0/s1
- IUPAC Name
- (2S)-2-amino-3-(naphthalen-1-yl)propanoic acid
- SMILES
- N[C@@H](CC1=CC=CC2=C1C=CC=C2)C(O)=O
References
- General References
- Not Available
- External Links
- PubChem Compound
- 2724883
- PubChem Substance
- 99443836
- ChemSpider
- 2006998
- ZINC
- ZINC000000391807
- PDBe Ligand
- ALN
- PDB Entries
- 1b0h / 1fiv / 2fiv / 3fiv / 3oe0 / 6hld / 6jv7 / 6ly6 / 6q36 / 8bv1 … show 4 more
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.221 mg/mL ALOGPS logP -0.44 ALOGPS logP -0.19 Chemaxon logS -3 ALOGPS pKa (Strongest Acidic) 2.61 Chemaxon pKa (Strongest Basic) 9.42 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 63.32 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 61.57 m3·mol-1 Chemaxon Polarizability 22.6 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9904 Blood Brain Barrier + 0.7409 Caco-2 permeable + 0.7206 P-glycoprotein substrate Non-substrate 0.5982 P-glycoprotein inhibitor I Non-inhibitor 0.9737 P-glycoprotein inhibitor II Non-inhibitor 0.9791 Renal organic cation transporter Non-inhibitor 0.8986 CYP450 2C9 substrate Non-substrate 0.8309 CYP450 2D6 substrate Non-substrate 0.8062 CYP450 3A4 substrate Non-substrate 0.7628 CYP450 1A2 substrate Inhibitor 0.5386 CYP450 2C9 inhibitor Non-inhibitor 0.9631 CYP450 2D6 inhibitor Non-inhibitor 0.8926 CYP450 2C19 inhibitor Non-inhibitor 0.9499 CYP450 3A4 inhibitor Non-inhibitor 0.9041 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9521 Ames test Non AMES toxic 0.8123 Carcinogenicity Non-carcinogens 0.8607 Biodegradation Not ready biodegradable 0.7331 Rat acute toxicity 2.0648 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9786 hERG inhibition (predictor II) Non-inhibitor 0.873
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-006x-3910000000-1d94c189483366df5265 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0uxr-0950000000-d1ffc01ea74fde796bfd Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-03di-2290000000-5a47b7f658410f3b7454 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0udi-0900000000-f562e799cd0ec5a8ea73 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-00di-5900000000-aeaf548ced08f78da3c5 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0f6x-0900000000-c042fd63edb0b0c16745 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0fbc-0900000000-adcaee0d80ee8059f120 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 147.00813 predictedDeepCCS 1.0 (2019) [M+H]+ 149.39673 predictedDeepCCS 1.0 (2019) [M+Na]+ 155.30925 predictedDeepCCS 1.0 (2019)
Targets
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1. DetailsPeriplasmic oligopeptide-binding protein
- Kind
- Protein
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity.
- Gene Name
- oppA
- Uniprot ID
- P06202
- Uniprot Name
- Periplasmic oligopeptide-binding protein
- Molecular Weight
- 61291.77 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
2. DetailsPol polyprotein
- Kind
- Protein
- Organism
- FIV
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse tra...
- Gene Name
- pol
- Uniprot ID
- P16088
- Uniprot Name
- Pol polyprotein
- Molecular Weight
- 127493.025 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Drug created at September 15, 2010 21:20 / Updated at June 12, 2020 16:52