This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Arginine glutamate is two amino acids indicated in the treatment of hyperammonemia and in combination for total parenteral nutrition.
- Generic Name
- Arginine glutamate
- DrugBank Accession Number
- DB13207
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Arginine glutamate (DB13207)
- Weight
- Average: 321.334
Monoisotopic: 321.164833481 - Chemical Formula
- C11H23N5O6
- Synonyms
- 2-amino-5-(diaminomethylideneamino)pentanoic acid
- 2-amino-5-guanidino-pentanoic acid
- 2-aminoglutaric acid
- Arginine glutamate
- L-Arginine L-glutamate
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Hyperammonaemia •••••••••••• ••••• •••••••••• •••••••• - Contraindications & Blackbox Warnings
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Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- International/Other Brands
- Modumate
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Nutriflex peri Infusionslösung Arginine glutamate (4.98 g) + Alanine (4.85 g) + Aspartic acid (1.5 g) + Calcium chloride (0.37 g) + Dextrose, unspecified form (80 g) + Glutamic acid (1.22 g) + Glycine (1.65 g) + Histidine (1.25 g) + Isoleucine (2.34 g) + Leucine (3.13 g) + Lysine hydrochloride (2.84 g) + Magnesium acetate (0.86 g) + Methionine (1.96 g) + Monopotassium phosphate (0.78 g) + Phenylalanine (3.51 g) + Potassium hydroxide (0.52 g) + Proline (3.4 g) + Serine (3 g) + Sodium acetate trihydrate (1.56 g) + Sodium chloride (0.17 g) + Sodium hydroxide (0.5 g) + Threonine (1.82 g) + Tryptophan (0.57 g) + Valine (2.6 g) Solution Parenteral B. Braun Melsungen Ag 2003-09-01 Not applicable Austria 
Nutriflex plus Infusionslösung Arginine glutamate (5.98 g) + Alanine (5.82 g) + Aspartic acid (1.8 g) + Calcium chloride dihydrate (0.53 g) + Dextrose, unspecified form (150 g) + Glutamic acid (1.47 g) + Glycine (1.98 g) + Histidine (1.5 g) + Isoleucine (2.82 g) + Leucine (3.76 g) + Lysine hydrochloride (3.41 g) + Magnesium acetate tetrahydrate (1.23 g) + Methionine (2.35 g) + Phenylalanine (4.21 g) + Potassium hydroxide (1.4 g) + Proline (4.08 g) + Serine (3.6 g) + Sodium acetate trihydrate (1.56 g) + Sodium hydroxide (0.23 g) + Sodium phosphate, monobasic (3.12 g) + Threonine (2.18 g) + Tryptophan (0.68 g) + Valine (3.12 g) Solution Parenteral B. Braun Melsungen Ag 1992-08-13 Not applicable Austria Nutriflex special Infusionslösung Arginine glutamate (8.72 g) + Alanine (8.49 g) + Aspartic acid (2.63 g) + Calcium chloride dihydrate (0.6 g) + Dextrose, unspecified form (240 g) + Glutamic acid (2.15 g) + Glycine (2.89 g) + Histidine (2.19 g) + Isoleucine (4.11 g) + Leucine (5.48 g) + Lysine hydrochloride (4.97 g) + Magnesium acetate tetrahydrate (1.08 g) + Methionine (3.42 g) + Monopotassium phosphate (2 g) + Phenylalanine (6.15 g) + Potassium hydroxide (0.62 g) + Proline (5.95 g) + Serine (5.25 g) + Sodium acetate trihydrate (1.63 g) + Sodium hydroxide (1.14 g) + Threonine (3.18 g) + Tryptophan (1 g) + Valine (4.54 g) Solution Parenteral B. Braun Melsungen Ag 1992-08-13 Not applicable Austria
Categories
- ATC Codes
- A05BA01 — Arginine glutamate
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as glutamic acid and derivatives. These are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Amino acids, peptides, and analogues
- Direct Parent
- Glutamic acid and derivatives
- Alternative Parents
- L-alpha-amino acids / Amino fatty acids / Dicarboxylic acids and derivatives / Guanidines / Amino acids / Propargyl-type 1,3-dipolar organic compounds / Carboxylic acids / Carboximidamides / Organopnictogen compounds / Organic oxides show 3 more
- Substituents
- Aliphatic acyclic compound / Alpha-amino acid / Amine / Amino acid / Amino fatty acid / Carbonyl group / Carboximidamide / Carboxylic acid / Dicarboxylic acid or derivatives / Fatty acid show 15 more
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- TU1X77K34Q
- CAS number
- 4320-30-3
- InChI Key
- RVEWUBJVAHOGKA-WOYAITHZSA-N
- InChI
- InChI=1S/C6H14N4O2.C5H9NO4/c7-4(5(11)12)2-1-3-10-6(8)9;6-3(5(9)10)1-2-4(7)8/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);3H,1-2,6H2,(H,7,8)(H,9,10)/t4-;3-/m00/s1
- IUPAC Name
- (2S)-2-amino-5-carbamimidamidopentanoic acid; (2S)-2-aminopentanedioic acid
- SMILES
- N[C@@H](CCC(O)=O)C(O)=O.N[C@@H](CCCNC(N)=N)C(O)=O
References
- General References
- AIFA Package Leaflet: BIOARGININA (arginine glutamate) intravenous injection [Link]
- External Links
- KEGG Drug
- D02397
- ChemSpider
- 144883
- 114464
- ChEBI
- 31234
- ChEMBL
- CHEMBL2104514
- Wikipedia
- Arginine_glutamate
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, solution Intravenous 20 G/500ML Solution Parenteral Injection, solution Intravenous Injection, solution - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 2.28 mg/mL ALOGPS logP -3.5 ALOGPS logP -3.2 Chemaxon logS -1.9 ALOGPS pKa (Strongest Acidic) 2.41 Chemaxon pKa (Strongest Basic) 12.41 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 125.22 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 53.92 m3·mol-1 Chemaxon Polarizability 17.86 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 165.58719 predictedDeepCCS 1.0 (2019) [M+H]+ 167.94518 predictedDeepCCS 1.0 (2019) [M+Na]+ 174.28404 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:37 / Updated at June 05, 2021 09:12