Propyphenazone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Propyphenazone
DrugBank Accession Number
DB13524
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 230.311
Monoisotopic: 230.141913208
Chemical Formula
C14H18N2O
Synonyms
  • 1-Phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one
  • 1-Phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one
  • 4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one
  • 4-Isopropylantipyrine
  • Isopropylantipyrine
  • Isopropylphenazone
  • Propifenazona
  • Propyphenazone
  • Propyphenazonum

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination for symptomatic treatment ofHeadacheCombination Product in combination with: Butalbital (DB00241), Caffeine (DB00201)•••••••••••••••••••••••• ••••••• ••••••
Used in combination for symptomatic treatment ofPainCombination Product in combination with: Butalbital (DB00241), Caffeine (DB00201)•••••••••••••••••••••••• ••••••• ••••••
Used in combination for symptomatic treatment ofPain, menstrualCombination Product in combination with: Caffeine (DB00201), Butalbital (DB00241)•••••••••••••••••••••••• ••••••• ••••••
Used in combination for symptomatic treatment ofRheumatismCombination Product in combination with: Caffeine (DB00201), Butalbital (DB00241)•••••••••••••••••••••••• ••••••• ••••••
Used in combination for symptomatic treatment ofRheumatism, muscularCombination Product in combination with: Butalbital (DB00241), Caffeine (DB00201)•••••••••••••••••••••••• ••••••• ••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirPropyphenazone may decrease the excretion rate of Abacavir which could result in a higher serum level.
AbciximabThe risk or severity of bleeding and hemorrhage can be increased when Propyphenazone is combined with Abciximab.
AcebutololPropyphenazone may decrease the antihypertensive activities of Acebutolol.
AceclofenacThe risk or severity of adverse effects can be increased when Aceclofenac is combined with Propyphenazone.
AcemetacinThe risk or severity of adverse effects can be increased when Propyphenazone is combined with Acemetacin.
Food Interactions
Not Available

Products

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International/Other Brands
Yoshipyrin
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Adolomed 250 mg/300 mg/50 mg TablettenPropyphenazone (250 mg) + Acetaminophen (300 mg) + Caffeine (50 mg)TabletOralKwizda Pharma Gmb H1986-08-22Not applicableAustria flag
ALJIL 150 MG/300 MG/50 MG TABLET, 20 ADETPropyphenazone (150 mg) + Acetaminophen (300 mg) + Caffeine (50 mg)TabletOralRECORDATİ İLAÇ SAN. VE TİC. A.Ş.1983-08-23Not applicableTurkey flag
BIOPTAN DRAJE, 30 ADETPropyphenazone (250 mg) + Caffeine (50 mg)Tablet, coatedOralBİOFARMA İLAÇ SAN. VE TİC. A.Ş.1985-01-04Not applicableTurkey flag
CISTALGANPropyphenazone (250 MG) + Flavoxate (200 MG)Tablet, coatedOralViatris Healthcare Limited2014-07-08Not applicableItaly flag
DERMAN 300/100/50 MG KAŞE, 1 KAŞEPropyphenazone (100 mg) + Acetaminophen (300 mg) + Caffeine (50 mg)PowderOralDERMAN İLAÇ SAN.VE TİC. A.Ş.1983-10-10Not applicableTurkey flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
GeworinPropyphenazone (150 mg/1) + Acetaminophen (300 mg/1)TabletOralLydia Co., Ltd.2023-02-11Not applicableUS flag
PANALGINE TABLET, 30 ADETPropyphenazone (150 mg) + Acetaminophen (300 mg) + Caffeine (30 mg)TabletOralATABAY İLAÇ FABRİKASI A.Ş.2013-01-29Not applicableTurkey flag
PAROL PLUS TABLET, 30 ADETPropyphenazone (150 mg) + Acetaminophen (250 mg) + Caffeine (50 mg)TabletOralATABAY KİMYA SAN. VE TİC. A.Ş.2013-01-29Not applicableTurkey flag

Categories

ATC Codes
N02BB74 — Propyphenazone, combinations with psycholepticsN02BB54 — Propyphenazone, combinations excl. psycholepticsN02BB04 — Propyphenazone
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as phenylpyrazoles. These are compounds containing a phenylpyrazole skeleton, which consists of a pyrazole bound to a phenyl group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Azoles
Sub Class
Pyrazoles
Direct Parent
Phenylpyrazoles
Alternative Parents
Pyrazolones / Benzene and substituted derivatives / Vinylogous amides / Heteroaromatic compounds / Lactams / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organic oxides
show 1 more
Substituents
Aromatic heteromonocyclic compound / Azacycle / Benzenoid / Heteroaromatic compound / Hydrocarbon derivative / Lactam / Monocyclic benzene moiety / Organic nitrogen compound / Organic oxide / Organic oxygen compound
show 6 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
pyrazolone (CHEBI:135538)
Affected organisms
Not Available

Chemical Identifiers

UNII
OED8FV75PY
CAS number
479-92-5
InChI Key
PXWLVJLKJGVOKE-UHFFFAOYSA-N
InChI
InChI=1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3
IUPAC Name
1,5-dimethyl-2-phenyl-4-(propan-2-yl)-2,3-dihydro-1H-pyrazol-3-one
SMILES
CC(C)C1=C(C)N(C)N(C1=O)C1=CC=CC=C1

References

General References
  1. TITCK Product Information: Minamol Plus (acetaminophen/caffeine/propyphenazone) oral tablets [Link]
KEGG Drug
D01380
ChemSpider
3646
RxNav
34710
ChEBI
135538
ChEMBL
CHEMBL28318
ZINC
ZINC000000049151
Wikipedia
Propyphenazone

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentMenstrual Distress (Dysmenorrhea)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Capsule
PowderOral
TabletOral
SuppositoryRectal
Tablet, coatedOral
Tablet, film coatedOral
Suppository
Tablet
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility9.26 mg/mLALOGPS
logP1.94ALOGPS
logP2.35Chemaxon
logS-1.4ALOGPS
pKa (Strongest Basic)0.47Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area23.55 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity69.92 m3·mol-1Chemaxon
Polarizability26.43 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0590000000-b45ad15ef4971f839e87
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0fsa-2920000000-5448545b1fe746778dc3
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001r-0690000000-a62e5f9e1a528954b203
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-0910000000-3af6eb80085a93ebcbb4
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-001i-0190000000-d499d58b0fccdbd7758d
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-3090000000-c435b95f4582900a2959
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-0090000000-9293361a181f107c8b46
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-5590000000-f839e93bcfb1ec26f8d8
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-00mp-9760000000-b8e4eade3470fa562e70
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9710000000-f32f5d91c37cc3c301e5
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-01x0-9620000000-12621d8a8d8b6fc69380
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-161.18663
predicted
DeepCCS 1.0 (2019)
[M+H]+163.54463
predicted
DeepCCS 1.0 (2019)
[M+Na]+169.63777
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:43 / Updated at September 28, 2021 21:54