This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Oxidronic acid
- DrugBank Accession Number
- DB14159
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Oxidronic acid (DB14159)
- Weight
- Average: 192.0
Monoisotopic: 191.958876529 - Chemical Formula
- CH6O7P2
- Synonyms
- (Hydroxymethylene)diphosphonic acid
- Acido oxidronico
- Acidum oxidronicum
- HMD-P
- HMDP
- Hydroxymethanediphosphonic acid
- Oxidronate
- Oxidronic acid
Pharmacology
- Indication
Oxidronic acid is a diagnostic skeletal imaging agent used to demonstrate areas of altered osteogenesis in adult and pediatric patients.1
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Diagnostic agent Osteogenesis imperfecta (oi) •••••••••••• •••••• ••••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Oxidronate disodium H852YK87WP 14255-61-9 VKKZUCSEWNITRU-UHFFFAOYSA-L - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image TechneScan HDP Injection, powder, lyophilized, for solution 3.15 mg/1 Intravenous Mallinckrodt 2007-02-27 2017-07-01 US 
Technescan HDP Injection, powder, lyophilized, for solution 3.15 mg/1 Intravenous Curium US LLC 2015-10-13 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 71MR4V32TI
- CAS number
- 15468-10-7
- InChI Key
- HJZKOAYDRQLPME-UHFFFAOYSA-N
- InChI
- InChI=1S/CH6O7P2/c2-1(9(3,4)5)10(6,7)8/h1-2H,(H2,3,4,5)(H2,6,7,8)
- IUPAC Name
- [hydroxy(phosphono)methyl]phosphonic acid
- SMILES
- OC(P(O)(O)=O)P(O)(O)=O
References
- General References
- FDA Approved Drug Products: Technescan HDP (Kit for the Preparation of Technetium Tc 99m Oxidronate), for intravenous use [Link]
- External Links
- ChemSpider
- 25412
- 1546448
- ChEBI
- 134844
- ChEMBL
- CHEMBL1615775
- ZINC
- ZINC000024740492
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, powder, lyophilized, for solution Intravenous 3 mg Injection, powder, lyophilized, for solution Intravenous Injection, powder, lyophilized, for solution Intravenous 3.15 mg/1 Injection, powder, for solution Intravenous 3 mg Injection, powder, for solution Intravenous 3.15 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 13.5 mg/mL ALOGPS logP -1.1 ALOGPS logP -2 Chemaxon logS -1.2 ALOGPS pKa (Strongest Acidic) 0.75 Chemaxon pKa (Strongest Basic) -5 Chemaxon Physiological Charge -3 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 135.29 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 29.72 m3·mol-1 Chemaxon Polarizability 12.21 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-00di-0900000000-a29349be9077d76ae0a3 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-002f-8900000000-64f211129525f5ad2f34 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0006-0900000000-7f88a2dd565b0ebfc5cf Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-00dl-0900000000-4057fe2cddb4eb05a22b Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-01q9-9000000000-bb46c92d409e5ad8d53b Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-03fr-9000000000-fc7d0b7166bbe341d34c Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 132.9185894 predictedDarkChem Lite v0.1.0 [M+H]+ 133.8500894 predictedDarkChem Lite v0.1.0 [M+Na]+ 133.0317894 predictedDarkChem Lite v0.1.0
Drug created at June 29, 2018 15:25 / Updated at February 21, 2021 18:54