NAV

Ramiprilat

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Ramiprilat
DrugBank Accession Number
DB14208
Background

The active metabolite of the prodrug Ramipril.

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 388.4574
Monoisotopic: 388.199822016
Chemical Formula
C21H28N2O5
Synonyms
  • Ramipril diacid
  • Ramiprilat
  • Ramiprilate
  • Ramiprilatum
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Integrate drug-drug
interactions in your software
AbaloparatideAbaloparatide may increase the hypotensive activities of Ramiprilat.
AcebutololAcebutolol may increase the hypotensive activities of Ramiprilat.
AceclofenacThe risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Aceclofenac is combined with Ramiprilat.
AcemetacinThe risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Acemetacin is combined with Ramiprilat.
Acetylsalicylic acidThe therapeutic efficacy of Ramiprilat can be decreased when used in combination with Acetylsalicylic acid.
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Dipeptides
Alternative Parents
N-acyl-L-alpha-amino acids / Alpha amino acid amides / L-alpha-amino acids / Pyrrolidine carboxylic acids / N-acylpyrrolidines / Aralkylamines / Benzene and substituted derivatives / Dicarboxylic acids and derivatives / Tertiary carboxylic acid amides / Amino acids
show 7 more
Substituents
Alpha-amino acid / Alpha-amino acid amide / Alpha-amino acid or derivatives / Alpha-dipeptide / Amine / Amino acid / Amino acid or derivatives / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle
show 25 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
azabicycloalkane, dipeptide, dicarboxylic acid, cyclopentapyrrole (CHEBI:77363)
Affected organisms
Not Available

Chemical Identifiers

UNII
6N5U4QFC3G
CAS number
87269-97-4
InChI Key
KEDYTOTWMPBSLG-HILJTLORSA-N
InChI
InChI=1S/C21H28N2O5/c1-13(22-16(20(25)26)11-10-14-6-3-2-4-7-14)19(24)23-17-9-5-8-15(17)12-18(23)21(27)28/h2-4,6-7,13,15-18,22H,5,8-12H2,1H3,(H,25,26)(H,27,28)/t13-,15-,16-,17-,18-/m0/s1
IUPAC Name
(2S,3aS,6aS)-1-[(2S)-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid
SMILES
[H][C@@]12CCC[C@]1([H])N([C@@H](C2)C(O)=O)C(=O)[C@H](C)N[C@@H](CCC1=CC=CC=C1)C(O)=O

References

General References
Not Available
Human Metabolome Database
HMDB0060579
ChemSpider
4576531
RxNav
1546377
ChEBI
77363
ChEMBL
CHEMBL1201365
ZINC
ZINC000004217399
PDBe Ligand
X92

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.214 mg/mLALOGPS
logP0.54ALOGPS
logP-0.18Chemaxon
logS-3.3ALOGPS
pKa (Strongest Acidic)3.13Chemaxon
pKa (Strongest Basic)8.05Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area106.94 Å2Chemaxon
Rotatable Bond Count8Chemaxon
Refractivity101.67 m3·mol-1Chemaxon
Polarizability40.37 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-00lu-9323000000-940b006da9cc06b5fc6f
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-01pc-0329000000-c6c95b23c1c9bc1420e6
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-0129000000-ca4996e2262139d40873
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-03di-1901000000-1858036e717f6160764f
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0ik9-0912000000-183f4396a17a30d5d214
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-07bf-3910000000-285646638f48929a1af3
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0w29-0900000000-4922fe2114280ad00d35
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-01pc-0329000000-c6c95b23c1c9bc1420e6
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-0129000000-ca4996e2262139d40873
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-03di-1901000000-1858036e717f6160764f
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0ik9-0912000000-183f4396a17a30d5d214
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-07bf-3910000000-285646638f48929a1af3
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0w29-0900000000-4922fe2114280ad00d35
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-205.92262
predicted
DarkChem Lite v0.1.0
[M-H]-184.80571
predicted
DeepCCS 1.0 (2019)
[M-H]-205.92262
predicted
DarkChem Lite v0.1.0
[M-H]-184.80571
predicted
DeepCCS 1.0 (2019)
[M+H]+204.29872
predicted
DarkChem Lite v0.1.0
[M+H]+187.20128
predicted
DeepCCS 1.0 (2019)
[M+H]+204.29872
predicted
DarkChem Lite v0.1.0
[M+H]+187.20128
predicted
DeepCCS 1.0 (2019)
[M+Na]+204.56692
predicted
DarkChem Lite v0.1.0
[M+Na]+193.11382
predicted
DeepCCS 1.0 (2019)
[M+Na]+204.56692
predicted
DarkChem Lite v0.1.0
[M+Na]+193.11382
predicted
DeepCCS 1.0 (2019)

Drug created at July 04, 2018 17:55 / Updated at February 21, 2021 18:54