Identification
- Generic Name
- Calcium ascorbate
- DrugBank Accession Number
- DB14483
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved, Nutraceutical
- Structure
Structure for Calcium ascorbate (DB14483)
- Weight
- Average: 390.31
Monoisotopic: 390.0111168 - Chemical Formula
- C12H14CaO12
- Synonyms
- Ascorbic acid calcium salt
- Calcium ascorbate
- Calcium ascorbate anhydrous
- Calcium diascorbate
- L-ascorbic acid, calcium salt (2:1)
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Vitamin c deficiency ••• ••• •••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAmphetamine The serum concentration of Amphetamine can be decreased when it is combined with Calcium ascorbate. Benzphetamine The serum concentration of Benzphetamine can be decreased when it is combined with Calcium ascorbate. Bleomycin The therapeutic efficacy of Bleomycin can be decreased when used in combination with Calcium ascorbate. Bortezomib The therapeutic efficacy of Bortezomib can be decreased when used in combination with Calcium ascorbate. Chlorpropamide Calcium ascorbate may decrease the excretion rate of Chlorpropamide which could result in a higher serum level. - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Calcium ascorbate dihydrate 183E4W213W 5743-28-2 RGJHWLDSRIHFKY-FWCDDDAWSA-L - Active Moieties
Name Kind UNII CAS InChI Key Ascorbic acid salt PQ6CK8PD0R 50-81-7 CIWBSHSKHKDKBQ-JLAZNSOCSA-N - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Ascorbate C-500 Capsule 500 mg Oral Seroyal International Inc. 1998-12-31 2001-08-09 Canada 
Buffered Vitamin C 1000mg Tablet 1000 mg Oral General Nutrition Canada Inc. 1997-11-26 2005-08-05 Canada Calcium Ascorbate 1000mg Capsule 1000 mg / cap Oral Natural Factors Nutritional Products Ltd. 1996-12-31 2007-08-07 Canada Calcium Ascorbate Crystals 1250mg/0.25tsp Powder 1.25 g / 1.25 mL Oral Swiss Herbal Remedies Ltd. 1987-12-31 2009-08-04 Canada Calcium Ascorbate Crystals Vitamin C 1gm/ml Powder 1 g / mL Oral Vita Health Products Inc 1991-12-31 2004-07-26 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image A/o-26 - Caplet Calcium ascorbate (250 mg) + Beta carotene (7500 unit) + Calcium (75 mg) + Copper (1 mg) + DL-alpha tocopheryl acetate (100 unit) + Folic acid (.4 mg) + Manganese (2.5 mg) + Racemethionine (50 mg) + Selenium (100 mcg) + Zinc (7.5 mg) Tablet Oral Enviro Tech International Canada 1996-12-19 1999-07-26 Canada Aces Caplet Calcium ascorbate (350 mg) + Beta carotene (15000 unit) + Chromium (25 mcg) + Selenium (100 mcg) + Vitamin E (200 unit) + Zinc (25 mg) Tablet Oral Nu Life Nutrition Ltd. 1997-08-15 2005-03-15 Canada Aces Tab Calcium ascorbate (350 mg) + Cholecalciferol (200 unit) + Chromium (25 mcg) + Selenium (100 mcg) + Vitamin A (5000 unit) + Vitamin E (200 unit) + Zinc (25 mg) Tablet Oral Nu Life Nutrition Ltd. 1987-12-31 2005-03-15 Canada Acti-megascorb Crystals Pwr Calcium ascorbate (2 g / 5 mL) + Calcium ascorbate (260 mg / 5 mL) Powder Oral Acti Form Ltd. 1991-12-31 2005-03-21 Canada Acti-megascorb Crystals Pwr Calcium ascorbate (2 g / 5 mL) + Calcium ascorbate (260 mg / 5 mL) Powder Oral Acti Form Ltd. 1991-12-31 2005-03-21 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Cavan One Calcium ascorbate dihydrate (25 mg/1) + Calcium (150 mg/1) + Cholecalciferol (170 [iU]/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Doconexent (260 mg/1) + Ferrous asparto glycinate (7 mg/1) + Folic acid (1 mg/1) + Icosapent (40 mg/1) + Iron (20 mg/1) + Linoleic acid (30 mg/1) + Pyridoxine hydrochloride (25 mg/1) + alpha-Linolenic acid (30 mg/1) Capsule, gelatin coated Oral Seton Pharmaceuticals 2009-10-30 2011-11-27 US 
Ferrex 150 Forte Plus Calcium ascorbate dihydrate (60 mg/1) + Calcium threonate (0.8 mg/1) + Cyanocobalamin (25 ug/1) + Folic acid (1 mg/1) + Iron (150 mg/1) + Succinic acid (50 mg/1) Capsule Oral Breckenridge Pharmaceutical, Inc. 2008-08-01 2012-09-30 US Folcaps Care One Calcium ascorbate dihydrate (24 mg/1) + Biotin (300 mg/1) + Calcium carbonate (100 mg/1) + Calcium threonate (1 mg/1) + Cholecalciferol (800 [iU]/1) + Doconexent (350 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Icosapent (100 mg/1) + Iodine (150 ug/1) + Iron (27 mg/1) + Magnesium (50 mg/1) + Nicotinamide (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.5 mg/1) + Zinc (5 mg/1) + alpha-Linolenic acid (50 mg/1) + alpha-Tocopherol acetate (15 [iU]/1) Capsule, gelatin coated Oral Mayne Pharma 2009-05-01 2016-12-31 US Folcaps Omega-3 Calcium ascorbate dihydrate (24 mg/1) + Calcium (150 mg/1) + Calcium threonate (1 mg/1) + Cholecalciferol (170 [iU]/1) + Doconexent (260 mg/1) + Ferrous asparto glycinate (7 mg/1) + Folic acid (1 mg/1) + Icosapent (40 mg/1) + Iron (20 mg/1) + Pyridoxine hydrochloride (25 mg/1) + alpha-Linolenic acid (30 mg/1) + alpha-Tocopherol acetate (30 [iU]/1) Capsule, gelatin coated Oral Mayne Pharma 2011-01-03 2016-12-31 US Nestabs ONE Calcium ascorbate dihydrate (18 mg/1) + Cholecalciferol (6.25 ug/1) + Cyanocobalamin (15 ug/1) + Doconexent (225 mg/1) + Folic acid (1 mg/1) + Iron (38 mg/1) + Magnesium oxide (15 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Tocopherol (10 mg/1) + Zinc oxide (1 mg/1) Capsule, gelatin coated Oral Womens Choice Pharmaceuticals, Llc 2017-07-20 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- J96U0ZD4Y6
- CAS number
- 5743-27-1
- InChI Key
- BLORRZQTHNGFTI-ZZMNMWMASA-L
- InChI
- InChI=1S/2C6H8O6.Ca/c2*7-1-2(8)5-3(9)4(10)6(11)12-5;/h2*2,5,7-10H,1H2;/q;;+2/p-2/t2*2-,5+;/m00./s1
- IUPAC Name
- calcium bis((2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate)
- SMILES
- [Ca++].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]
References
- General References
- Not Available
- External Links
- ChemSpider
- 22900989
- ChEMBL
- CHEMBL2146095
- Wikipedia
- Calcium_ascorbate
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet Oral 166.7 mg / tab Tablet Oral 1000 mg Capsule Oral 1000 mg / cap Powder Oral 1.25 g / 1.25 mL Powder Oral 1 g / mL Powder Oral 4.5 g / 5 mL Powder Oral 825 mg / g Powder Oral 1.3 g / 1.25 mL Capsule, gelatin coated Oral Tablet Oral 250 mg / tab Tablet, coated Oral Tablet, extended release Oral Powder, for solution Oral Tablet Oral 500 mg / tab Capsule Oral Tablet Oral Gel Oral Capsule Oral 500 mg / cap Tablet, effervescent Oral Tablet Oral Tablet, film coated Powder Capsule Oral 660 mg / cap Capsule Oral 500 mg Powder Oral 1000 mg / 1.25 g Capsule, liquid filled Oral Pill Oral Tablet, chewable Oral Tablet, film coated Oral Kit Oral Capsule Oral 200 mg / cap Emulsion Topical Liquid Oral Tablet Oral 1 g Tablet Oral 500 mg Capsule Oral 600 mg / cap Powder Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 16.0 mg/mL ALOGPS logP -1.6 ALOGPS logP -1.9 Chemaxon logS -1.4 ALOGPS pKa (Strongest Acidic) 4.36 Chemaxon pKa (Strongest Basic) -3 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 110.05 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 47.58 m3·mol-1 Chemaxon Polarizability 14.48 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at July 06, 2018 22:11 / Updated at April 19, 2024 20:55