NAV

Teprenone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Teprenone is a medication indicated in the treatment of acute gastroenteritis, exacerbations of gastric inflammation, and gastric ulcers.

Generic Name
Teprenone
DrugBank Accession Number
DB15955
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 330.556
Monoisotopic: 330.292265844
Chemical Formula
C23H38O
Synonyms
  • Geranylgeranylacetone
  • Teprenona
  • Teprenone
  • Teprenonum
  • Tetraprenylacetone
External IDs
  • E-0671
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Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Treatment ofAcute gastroenteritis•••••••••••••••••••
Treatment ofGastritis chronic•••••••••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action

Teprenone acts as an anti-ulcer and gastric mucoprotective agent used to treat gastric ulcers and gastritis. Currently, the full mechanisms of action are still unclear.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Categories

ATC Codes
A02BX15 — Teprenone
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
57B67OXM8F
CAS number
6809-52-5
InChI Key
HUCXKZBETONXFO-NJFMWZAGSA-N
InChI
InChI=1S/C23H38O/c1-19(2)11-7-12-20(3)13-8-14-21(4)15-9-16-22(5)17-10-18-23(6)24/h11,13,15,17H,7-10,12,14,16,18H2,1-6H3/b20-13+,21-15+,22-17+
IUPAC Name
(5E,9E,13E)-6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one
SMILES
CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CCC(C)=O

References

General References
  1. Nishida K, Ohta Y, Ishiguro I: Teprenone, an anti-ulcer agent, increases gastric mucosal mucus level via nitric oxide in rats. Jpn J Pharmacol. 1998 Dec;78(4):519-22. doi: 10.1254/jjp.78.519. [Article]
  2. Tanoue K, Tarnawski AS, Kishihara F, Ohta M, Hashizume M, Sugimachi K, Sarfeh IJ: Effect of teprenone on portal hypertensive gastric mucosa. Digestion. 1996;57(1):35-40. doi: 10.1159/000201310. [Article]
  3. FDA Thailand: SELBEX (teprenone) oral capsule [Link]
KEGG Compound
C13297
ChemSpider
4445389
RxNav
1362746
ChEMBL
CHEMBL79686
ZINC
ZINC000001915509
Wikipedia
Teprenone

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentChronic Erosive Gastritis1
4CompletedTreatmentGastric Ulcer1
2Enrolling by InvitationTreatmentHeart Failure With Preserved Ejection Fraction (HFpEF)1
2, 3CompletedPreventionGastric or Duodenal Ulcers Caused by Low-dose Aspirin1
Not AvailableUnknown StatusPreventionNon-steroidal Anti-inflammatory Drug Adverse Reaction1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Capsule50 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0016 mg/mLALOGPS
logP6.99ALOGPS
logP7Chemaxon
logS-5.3ALOGPS
pKa (Strongest Acidic)19.6Chemaxon
pKa (Strongest Basic)-7.3Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count1Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area17.07 Å2Chemaxon
Rotatable Bond Count12Chemaxon
Refractivity111.43 m3·mol-1Chemaxon
Polarizability43.45 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-07cr-1394000000-e228a321c1b96ac532bd
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-056r-4009000000-62ac91cc9ad2c046a330
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-9001000000-2c118faa1b556c968311
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-067i-2790000000-26a552d073a3ff0892e1
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-9230000000-c5e9a05f9959716b9260
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-053u-6920000000-970ba016b3016bdaf4fe
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at November 26, 2020 20:56 / Updated at May 07, 2021 21:09