Imaradenant
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Imaradenant
- DrugBank Accession Number
- DB16192
- Background
Imaradenant is under investigation in clinical trial NCT03381274 (Oleclumab (MEDI9447) Egfrm NSCLC Novel Combination Study).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 315.74
Monoisotopic: 315.0687012 - Chemical Formula
- C15H11ClFN5
- Synonyms
- Imaradenant
- External IDs
- AZD 4635
- AZD-4635
- AZD4635
- HTL-1071
- HTL1071
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 770140J08A
- CAS number
- 1321514-06-0
- InChI Key
- NCWQLHHDGDXIJN-UHFFFAOYSA-N
- InChI
- InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)
- IUPAC Name
- 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine
- SMILES
- CC1=NC(Cl)=CC(=C1)C1=NN=C(N)N=C1C1=CC=C(F)C=C1
References
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Metastatic Castration-Resistant Prostate Cancer (mCRPC) / Prostate Cancer 1 2 Completed Treatment Progressive Metastatic Castrate Resistant Prostate Cancer 1 1 Completed Basic Science Healthy Volunteers (HV) 1 1 Completed Other Advanced Malignant Solid Tumor 1 1 Completed Treatment Advanced Malignant Solid Tumor / Colorectal Carcinoma (CRC) / Metastatic Castration-Resistant Prostate Cancer (mCRPC) / Non-Small Cell Lung Cancer (NSCLC) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.032 mg/mL ALOGPS logP 2.89 ALOGPS logP 2.87 Chemaxon logS -4 ALOGPS pKa (Strongest Acidic) 14.87 Chemaxon pKa (Strongest Basic) 3.04 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 77.58 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 85.28 m3·mol-1 Chemaxon Polarizability 29.96 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-014i-0009000000-0a655f4dfc9f83e34120 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-03di-0009000000-9154acf580cf598de22a Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-014i-0029000000-713776541b0b633e1f90 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-03di-0009000000-85cd23584adfce74c289 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0007-0190000000-002dac5bc962853817ab Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-5690000000-cdf91f12d3dc9ee41a3e Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at December 15, 2020 18:15 / Updated at February 21, 2021 18:55