Butabarbital sodiumProduct ingredient for Butabarbital
- Name
- Butabarbital sodium
- Drug Entry
- Butabarbital
Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates.1,12 This makes butabarbital a useful drug for treating severe insomnia and pre-operative anxiety.1,12 Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines.3 Its short duration of action gives butabarbital a high abuse potential, comparable to secobarbital.1,2
Butabarbital was granted FDA approval on 5 June 1939.12
- Accession Number
- DBSALT000312
- Structure
Structure for Butabarbital sodium (DBSALT000312)
- Synonyms
- Not Available
- UNII
- 9WTD50I918
- CAS Number
- 143-81-7
- Weight
- Average: 234.2275
Monoisotopic: 234.098037031 - Chemical Formula
- C10H15N2NaO3
- InChI Key
- QORQZMBCPRBCAB-UHFFFAOYSA-M
- InChI
- InChI=1S/C10H16N2O3.Na/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14;/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15);/q;+1/p-1
- IUPAC Name
- sodium 5-(butan-2-yl)-5-ethyl-6-hydroxy-2-oxo-2,5-dihydropyrimidin-4-olate
- SMILES
- [Na+].CCC(C)C1(CC)C(O)=NC(=O)N=C1[O-]
- External Links
- PubChem Compound
- 23690439
- ChemSpider
- 8593
- ChEBI
- 3229
- ChEMBL
- CHEMBL1200982
- Wikipedia
- Butabarbital
- Predicted Properties
Property Value Source Water Solubility 0.513 mg/mL ALOGPS logP 1.78 ALOGPS logP 2.18 Chemaxon logS -2.7 ALOGPS pKa (Strongest Acidic) 1.33 Chemaxon pKa (Strongest Basic) -4.1 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 85.08 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 64.6 m3·mol-1 Chemaxon Polarizability 20.81 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon