Ceftizoxime sodiumProduct ingredient for Ceftizoxime

Name
Ceftizoxime sodium
Drug Entry
Ceftizoxime

A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.

Accession Number
DBSALT001162
Structure
Synonyms
Not Available
UNII
26337D5X88
CAS Number
68401-82-1
Weight
Average: 405.38
Monoisotopic: 405.01775513
Chemical Formula
C13H12N5NaO5S2
InChI Key
ADLFUPFRVXCDMO-LIGXYSTNSA-M
InChI
InChI=1S/C13H13N5O5S2.Na/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18;/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22);/q;+1/p-1/b17-7-;/t8-,11-;/m1./s1
IUPAC Name
sodium (2Z)-N-[(6R,7R)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]-2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)ethanecarboximidate
SMILES
[Na+].[H][C@]12SCC=C(N1C(=O)[C@@]2([H])N=C([O-])C(=N/OC)\C1=CSC(=N)N1)C(O)=O
KEGG Compound
C08118
ChemSpider
7962928
ChEBI
3512
ChEMBL
CHEMBL1201019
Wikipedia
Ceftizoxime
Predicted Properties
PropertyValueSource
Water Solubility0.295 mg/mLALOGPS
logP1.02ALOGPS
logP0.7Chemaxon
logS-3.1ALOGPS
pKa (Strongest Acidic)3.29Chemaxon
pKa (Strongest Basic)0.72Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count9Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area150.5 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity113.76 m3·mol-1Chemaxon
Polarizability35.59 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon