Cefalexin hydrochlorideProduct ingredient for Cephalexin
- Name
- Cefalexin hydrochloride
- Drug Entry
- Cephalexin
Cephalexin is the first of the first generation cephalosporins.7,8 This antibiotic contains a beta lactam and a dihydrothiazide.7 Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.9,Label Cephalexin was approved by the FDA on 4 January 1971.12
- Accession Number
- DBSALT001473
- Structure
Structure for Cefalexin hydrochloride (DBSALT001473)
- Synonyms
- Cefalexin HCl / Cefalexin hydrochloride monohydrate / Cephalexin HCl / Cephalexin hydrochloride / Cephalexin monohydrochloride monohydrate
- UNII
- 6VJE5G3D98
- CAS Number
- 105879-42-3
- Weight
- Average: 401.86
Monoisotopic: 401.0812196 - Chemical Formula
- C16H20ClN3O5S
- InChI Key
- YHJDZIQOCSDIQU-OEDJVVDHSA-N
- InChI
- InChI=1S/C16H17N3O4S.ClH.H2O/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;;/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23);1H;1H2/t10-,11-,15-;;/m1../s1
- IUPAC Name
- (6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate hydrochloride
- SMILES
- O.Cl.[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=CC=C1)C(O)=O
- External Links
- ChemSpider
- 56687
- ChEMBL
- CHEMBL1200366
- Predicted Properties
Property Value Source Water Solubility 0.297 mg/mL ALOGPS logP 0.55 ALOGPS logP -2.1 Chemaxon logS -3.1 ALOGPS pKa (Strongest Acidic) 3.45 Chemaxon pKa (Strongest Basic) 7.23 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 112.73 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 88.97 m3·mol-1 Chemaxon Polarizability 34.94 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon