Carfentanil citrateProduct ingredient for Carfentanil
- Name
- Carfentanil citrate
- Drug Entry
- Carfentanil
Carfentanil or carfentanyl (Wildnil) is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known (also the most potent opioid used commercially). Carfentanil was first synthesized in 1974 by a team of chemists at Janssen Pharmaceutica which included Paul Janssen. It has a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl, with activity in humans starting at about 1 microgram. It is marketed under the trade name Wildnil as a general anaesthetic agent for large animals. Carfentanil is intended for large-animal use only as its extreme potency makes it inappropriate for use in humans. Currently sufentanil, approximately 10–20 times less potent (500 to 1000 times the efficacy of morphine per weight) than carfentanil, is the maximum strength fentanyl analog for use in humans.
- Accession Number
- DBSALT001611
- Structure
- Synonyms
- Not Available
- UNII
- 7LG286J8GV
- CAS Number
- 61380-27-6
- Weight
- Average: 586.638
Monoisotopic: 586.252645432 - Chemical Formula
- C30H38N2O10
- InChI Key
- ZSLYVCXNFQPCGT-UHFFFAOYSA-N
- InChI
- InChI=1S/C24H30N2O3.C6H8O7/c1-3-22(27)26(21-12-8-5-9-13-21)24(23(28)29-2)15-18-25(19-16-24)17-14-20-10-6-4-7-11-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-13H,3,14-19H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
- IUPAC Name
- 2-hydroxypropane-1,2,3-tricarboxylic acid; methyl 1-(2-phenylethyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate
- SMILES
- OC(=O)CC(O)(CC(O)=O)C(O)=O.CCC(=O)N(C1=CC=CC=C1)C1(CCN(CCC2=CC=CC=C2)CC1)C(=O)OC
- External Links
- ChemSpider
- 8027078
- ChEMBL
- CHEMBL2106383
- Predicted Properties
Property Value Source Water Solubility 0.0259 mg/mL ALOGPS logP 3.7 ALOGPS logP 3.67 Chemaxon logS -4.2 ALOGPS pKa (Strongest Basic) 8.05 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 49.85 Å2 Chemaxon Rotatable Bond Count 13 Chemaxon Refractivity 114.38 m3·mol-1 Chemaxon Polarizability 43.79 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon