GenoBrowse
| Drug Name | Interacting Gene/Enzyme | SNP(s) | Adverse Reaction | Reference(s) |
|---|---|---|---|---|
| 5-Fluororuacil DB00544  |
Orotate phophoribosyltransferase, Uridine 5'-monophosphate synthase (Gene symbol = OPRT or UMPS) Swissprot P11172 | rs1801019 (C Allele) | Neutropenia, diarrhea | Ichikawa W, Takahashi T, Suto K, Sasaki Y, Hirayama R: Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen. Clin Cancer Res. 2006 Jul 1;12(13):3928-34. [PubMed] |
| 5-Fluororuacil DB00544 |
Thymidylate synthase (Gene symbol = TYMS) Swissprot P04818 | TSER*2 rs34743033 | Neutropenia, diarrhea | Ichikawa W, Takahashi T, Suto K, Sasaki Y, Hirayama R: Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen. Clin Cancer Res. 2006 Jul 1;12(13):3928-34. [PubMed] |
| 5-Fluoruracil DB00544 |
Dihydropyrimidine dehydrogenase (Gene symbol = DPYD) Swissprot Q12882 | rs1801265 (C allele) rs1801159 (G allele) | Nausea, vomiting, reduced white cell count | Zhang H, Li YM, Zhang H, Jin X: DPYD*5 gene mutation contributes to the reduced DPYD enzyme activity and chemotherapeutic toxicity of 5-FU: results from genotyping study on 75 gastric carcinoma and colon carcinoma patients. Med Oncol. 2007;24(2):251-8. [PubMed] |
| 5-Fluoruracil DB00544 |
Glutathione S-Transferase P1 (Gene symbol = GSTP1) Swissprot P09211 | rs1695 (A allele) | Hematological toxicity, gastrointestinal toxicity | Agostini M, Pasetto LM, Pucciarelli S, Terrazzino S, Ambrosi A, Bedin C, Galdi F, Friso ML, Mescoli C, Urso E, Leon A, Lise M, Nitti D: Glutathione S-Transferase P1 Ile105Val Polymorphism is Associated with Haematological Toxicity in Elderly Rectal Cancer Patients Receiving Preoperative Chemoradiotherapy. Drugs Aging. 2008;25(6):531-9. [PubMed] |
| 5-Fluoruracil DB00544 |
Dihydropyrimidine dehydrogenase (Gene symbol = DPYD) Swissprot Q12882 | rs3918290 (A allele) | Leukopenia, diarrhea, mucositis | Schwab M, Zanger UM, Marx C, Schaeffeler E, Klein K, Dippon J, Kerb R, Blievernicht J, Fischer J, Hofmann U, Bokemeyer C, Eichelbaum M: Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group. J Clin Oncol. 2008 May 1;26(13):2131-8. Epub 2008 Feb 25. [PubMed] |
| Acetretin DB00459 |
Apolipoprotein E (Gene symbol = APOE) Swissprot P02649 | rs429358 (C allele) rs7412 (C allele) | Psoriasis | Campalani E, Allen MH, Fairhurst D, Young HS, Mendonca CO, Burden AD, Griffiths CE, Crook MA, Barker JN, Smith CH: Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. Br J Dermatol. 2006 Feb;154(2):345-52. [PubMed] |
| Amitriptyline DB00321 |
Multidrug resistance protein 1 (Gene symbol = ABCB1) Swissprot P08183 | rs1045642 (T Allele, homozygous) | Postural hypotension | Roberts RL, Joyce PR, Mulder RT, Begg EJ, Kennedy MA: A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression. Pharmacogenomics J. 2002;2(3):191-6. [PubMed] |
| Aspirin DB00945 |
Leukotriene C4 Synthase (Gene symbol = LTC4S) Swissprot Q16873 | rs730012 (C allele) | Aspirin-induced urticaria | Mastalerz L, Setkowicz M, Sanak M, Rybarczyk H, Szczeklik A: Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant. Br J Dermatol. 2006 Feb;154(2):256-60. [PubMed] |
| Azathioprine DB00993 |
Thiopurine S-methyltransferase (Gene symbol = TPMT) Swissprot P51580 | TMPT*2 rs1800462 (G Allele) | Hepatotoxicity | Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed] |
| Azathioprine DB00993 |
Thiopurine S-methyltransferase (Gene symbol = TPMT) Swissprot P51580 | TMPT*3A rs1800460 (A Allele) | Hepatotoxicity | Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed] |
| Azathioprine DB00993 |
Thiopurine S-methyltransferase (Gene symbol = TPMT) Swissprot P51580 | TMPT*3C rs1142345 (G Allele) | Hepatotoxicity | Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed] |
| Caffeine DB00201 |
Cytochrome P450 1A2 (Gene symbol = CYP1A2) Swissprot P05177 | rs762551 (C allele) | Myocardial infarction | Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H: Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA. 2006 Mar 8;295(10):1135-41. [PubMed] |
| Carbamazepine DB00564 |
Heat shock 70 kDa protein 1L (gene symbol = HSPA1L) Swissprot P34931 | rs2227956 (T allele) | Hypersensitivity reaction, mild erythematous skin rashes, macropapular eruption, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis | Alfirevic A, Mills T, Harrington P, Pinel T, Sherwood J, Jawaid A, Smith JC, March RE, Barratt BJ, Chadwick DW, Kevin Park B, Pirmohamed M: Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. [PubMed] |
| Carbamazepine DB00564 |
Heat shock 70 kDa protein 1 (gene symbol HSPA1A) Swissprot P08107 | rs506770 (C allele) rs1043620 (C allele) | Hypersensitivity reaction, mild erythematous skin rashes, macropapular eruption, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis | Alfirevic A, Mills T, Harrington P, Pinel T, Sherwood J, Jawaid A, Smith JC, March RE, Barratt BJ, Chadwick DW, Kevin Park B, Pirmohamed M: Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. [PubMed] |
| Carbamazepine DB00564 |
MHC class I antigen B*15, HLA-B*1502 (Gene symbol = HLAB) Swissprot P30464 | rs3130690 (T allele) | Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis | Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr;16(4):297-306. [PubMed] |
| Carbamazepine DB00564 |
MHC class 1 antigen, A*31, HLA-A*3101 (Gene symbol = HLAA) Swissprot P16189 | rs1264511 (G allele) | Macropapular eruption | Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr;16(4):297-306. [PubMed] |
| Carbamazepine DB00564 |
Motilin (Gene symbol = MLN) Swissprot P12872 | rs2894342 (A allele) | Hypersensitivity syndrome | Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr;16(4):297-306. [PubMed] |
| Cisplatin DB00515 |
Megalin, Low-density lipoprotein receptor-related protein 2 (gene symbol = LRP2) Swissprot P98164 | rs2075252 (A allele) rs4668123 (T allele) | Ototoxicity (hearing loss) | Riedemann L, Lanvers C, Deuster D, Peters U, Boos J, Jurgens H, am Zehnhoff-Dinnesen A: Megalin genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Pharmacogenomics J. 2008 Feb;8(1):23-8. Epub 2007 Apr 24. [PubMed] |
| Cisplatin DB00515 |
Glutathione S-Transferase P1 (Gene symbol = GSTP1) Swissprot P09211 | rs1695 (A allele) | Tinnitus, hearing impairment, Raynaud syndrome | Oldenburg J, Kraggerud SM, Brydoy M, Cvancarova M, Lothe RA, Fossa SD: Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study. J Transl Med. 2007 Dec 27;5:70. [PubMed] |
| Cisplatin DB00515 |
Glutathione S-Transferase Mu 1 (Gene symbol = GSTM1) Swissprot P09488 | GSTM1 (presence) | Tinnitus, hearing impairment, Raynaud syndrome | Oldenburg J, Kraggerud SM, Brydoy M, Cvancarova M, Lothe RA, Fossa SD: Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study. J Transl Med. 2007 Dec 27;5:70. [PubMed] |
| Citalopram DB00215 |
cAMP response element-binding protein (Gene symbol = CREB1) Swissprot P16220 | rs4675690 (T Allele) rs7569963 (A Allele) | Elevated suicide risk | Perlis RH, Purcell S, Fava M, Fagerness J, Rush AJ, Trivedi MH, Smoller JW: Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study. Arch Gen Psychiatry. 2007 Jun;64(6):689-97. [PubMed] |
| Citalopram DB00215 |
Glutamate receptor 6 (Gene symbol = GRIK2) Swissprot Q13002 | rs2518224 (C Allele, homozygote) | Increased suicidal thoughts | Laje G, Paddock S, Manji H, Rush AJ, Wilson AF, Charney D, McMahon FJ: Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. Am J Psychiatry. 2007 Oct;164(10):1530-8. [PubMed] |
| Citalopram DB00215 |
Glutamate receptor 3 (Gene symbol = GRIA3) Swissprot P42263 | rs4825476 (G Allele, homozygote) | Increased suicidal thoughts | Laje G, Paddock S, Manji H, Rush AJ, Wilson AF, Charney D, McMahon FJ: Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. Am J Psychiatry. 2007 Oct;164(10):1530-8. [PubMed] |
| Coumarin | Cytochrome P450 2A6 (Gene symbol = CYP2A6) Swissprot P11509 | CYP2A6*2 rs1801272 (A Allele) | Hepatotoxicity | Farinola N, Piller NB: CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients? Pharmacogenomics. 2007 Feb;8(2):151-8. [PubMed] |
| Cyclosporine DB00091 |
Cytotoxic T-lymphocyte antigen 4 (Gene symbol = CTLA-4) Swissprot P16410 | rs231775 (A Allele) | Gingival overgrowth, periodontal disease | Kusztal M, Radwan-Oczko M, Koscielska-Kasprzak K, Boratynska M, Patrzalek D, Klinger M: Possible association of CTLA-4 gene polymorphism with cyclosporine-induced gingival overgrowth in kidney transplant recipients. Transplant Proc. 2007 Nov;39(9):2763-5. [PubMed] |
| Daunorubicin DB00694 |
Cytochrome P450 1B1 (Gene symbol = CYP1B1) Swissprot Q16678 | rs10932125 (G allele) | Myelosuppression, cardiac toxicity, cytotoxicty | Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. [PubMed] |
| Daunorubicin DB00694 |
Heterogeneous nuclear ribonucleoprotein D0 (Gene symbol = HNRPD) Swissprot Q14103 | rs3750518 (A allele) | Myelosuppression, cardiac toxicity, cytotoxicty | Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. [PubMed] |
| Daunorubicin DB00694 |
Tocopherol-associated protein 2 (Gene symbol = TAP2) Swissprot Q9UDX4 | rs6603859 (T allele) | Myelosuppression, cardiac toxicity, cytotoxicty | Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. [PubMed] |
| Daunorubicin DB00694 |
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Gene symbol = IKBKE) Swissprot Q14164 | rs7929521 (A allele) | Myelosuppression, cardiac toxicity, cytotoxicty | Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. [PubMed] |
| Docetaxel DB01248 |
Canalicular multispecific organic anion transporter 1 (Gene symbol = ABCC2) Swissprot Q92887 | rs12762549 (G Allele) | Leukopenia, neutropenia | Kiyotani K, Mushiroda T, Kubo M, Zembutsu H, Sugiyama Y, Nakamura Y: Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Cancer Sci. 2008 May;99(5):967-72. Epub 2008 Feb 19. [PubMed] |
| Gefitinib DB00317 |
ATP-binding cassette sub-family G member 2 (Gene symbol ABCG2) Swissprot Q9UNQ0 | rs2231142 (A Allele) | Diarrhea | Cusatis G, Gregorc V, Li J, Spreafico A, Ingersoll RG, Verweij J, Ludovini V, Villa E, Hidalgo M, Sparreboom A, Baker SD: Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42. [PubMed] |
| Gemcitabine DB00441 |
Ribonucleotide-diphosphate reductase M1 polypeptide (Gene symbol = RRM1) Swissprot P23921 | rs3177016 (A Allele) rs1042858 (G Allele) | Neutropenia | Rha SY, Jeung HC, Choi YH, Yang WI, Yoo JH, Kim BS, Roh JK, Chung HC: An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. Oncologist. 2007 Jun;12(6):622-30. [PubMed] |
| Irinotecan DB00762 |
Solute carrier organic anion transporter family member 1B1 (Gene symbol = SLCO1B1) Swissprot Q9Y6L6 | SLCO1B1*15 rs4149056 (C Allele) rs2306283 (G Allele) | Diarrhea, leucopenia, neutropenia | Takane H, Miyata M, Burioka N, Kurai J, Fukuoka Y, Suyama H, Shigeoka Y, Otsubo K, Ieiri I, Shimizu E: Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele. Ther Drug Monit. 2007 Oct;29(5):666-8. [PubMed] |
| Irinotecan DB00762 |
UDP-glucuronosyltransferase 1-1 (Gene symbol = UGT1A1) Swissprot P22309 | rs10929302 (A Allele) | Hematological toxicity, neutropenia | Cote JF, Kirzin S, Kramar A, Mosnier JF, Diebold MD, Soubeyran I, Thirouard AS, Selves J, Laurent-Puig P, Ychou M: UGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan. Clin Cancer Res. 2007 Jun 1;13(11):3269-75. Epub 2007 May 17. [PubMed] |
| Irinotecan DB00762 |
UDP-glucuronosyltransferase 1-1 (Gene symbol = UGT1A1) Swissprot P22309 | UGT1A1*28 or UGT1A 7/7 rs8175347 (extra TA in promoter) | Leukopenia, thrombpocytopenia | Lankisch TO, Schulz C, Zwingers T, Erichsen TJ, Manns MP, Heinemann V, Strassburg CP: Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):695-701. [PubMed]
Fakih MG, Ross ME, Starostik P: Increased frequency of uridine diphosphate glucuronosyltransferase 1A1 7/7 in patients experiencing severe irinotecan-induced toxicities. Clin Colorectal Cancer. 2007 Jul;6(8):583-7. [PubMed] |
| Irinotecan DB00762 |
UDP-glucuronosyltransferase 1-7 (Gene symbol = UGT1A7) Swissprot Q9HAW7 | rs17868323 (G allele) rs17863778 (A allele) rs17868324 (A allele) | Leukopenia, thrombpocytopenia | Lankisch TO, Schulz C, Zwingers T, Erichsen TJ, Manns MP, Heinemann V, Strassburg CP: Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):695-701. [PubMed] |
| Isoniazid DB00951 |
Cytochrome P450 2E1 (Gene symbol = CYP2E1) Swissprot P05181 | CYP2E1 *1A rs6413419 (G Allele, homozygote) | Hepatotoxicity | Vuilleumier N, Rossier MF, Chiappe A, Degoumois F, Dayer P, Mermillod B, Nicod L, Desmeules J, Hochstrasser D: CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis. Eur J Clin Pharmacol. 2006 Jun;62(6):423-9. Epub 2006 Apr 27. [PubMed] |
| Leflunomide DB01097 |
Cytochrome P450 1A2 (Gene symbol = CYP1A2) Swissprot P05177 | rs762551 (C allele) | Diarrhea, vomiting, liver toxicity, headache, insomnia, rash, alopecia, hypertension, leucopenia, asthma | Bohanec Grabar P, Rozman B, Tomsic M, Suput D, Logar D, Dolzan V: Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients. Eur J Clin Pharmacol. 2008 May 22;. [PubMed] |
| Mercaptopurine DB01033 |
Thiopurine S-methyltransferase (Gene symbol = TPMT) Swissprot P51580 | TMPT*2 rs1800462 (G Allele) | Hepatotoxicity | Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed] |
| Mercaptopurine DB01033 |
Thiopurine S-methyltransferase (Gene symbol = TPMT) Swissprot P51580 | TMPT*3A rs1800460 (A Allele) | Hepatotoxicity | Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed] |
| Mercaptopurine DB01033 |
Thiopurine S-methyltransferase (Gene symbol = TPMT) Swissprot P51580 | TMPT*3C rs1142345 (G Allele) | Hepatotoxicity | Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [PubMed] |
| Methamphetamine DB01577 |
PRKCA-binding protein (Gene symbol = PICK1) Swissprot Q9NRD5 | rs713729 (T allele) rs2076369 (G allele) | Methamphetamine psychosis and addiction | Matsuzawa D, Hashimoto K, Miyatake R, Shirayama Y, Shimizu E, Maeda K, Suzuki Y, Mashimo Y, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Hata A, Sawa A, Iyo M: Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis. Am J Psychiatry. 2007 Jul;164(7):1105-14. [PubMed] |
| Methotrexate DB00563 |
Methylenetetrahydrofolate reductase (Gene symbol = MTHFR) Swissprot P42898 | rs1801133 (T allele) | Mucositis, hepatic toxicity, thrombocytopenia, alopecia | Gemmati D, Ongaro A, Tognazzo S, Catozzi L, Federici F, Mauro E, Della Porta M, Campioni D, Bardi A, Gilli G, Pellati A, Caruso A, Scapoli GL, De Mattei M: Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: association with toxicity and survival. Haematologica. 2007 Apr;92(4):478-85. [PubMed] |
| Methotrexate DB00563 |
Canalicular multispecific organic anion transporter 1 (Gene symbol = ABCC2) Swissprot Q92887 | ABCC2 IVS 23+56 (T allele) | General toxicity (gastrointestinal and hepatotoxicity) | Ranganathan P, Culverhouse R, Marsh S, Mody A, Scott-Horton TJ, Brasington R, Joseph A, Reddy V, Eisen S, McLeod HL: Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. J Rheumatol. 2008 Apr;35(4):572-9. Epub 2008 Mar 15. [PubMed] |
| Nortryptyline DB00540 |
Multidrug resistance protein 1 (Gene symbol = ABCB1) Swissprot P08183 | rs1045642 (T Allele, homozygous) | Postural hypotension | Roberts RL, Joyce PR, Mulder RT, Begg EJ, Kennedy MA: A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression. Pharmacogenomics J. 2002;2(3):191-6. [PubMed] |
| Trastuzumab DB0072 |
Receptor tyrosine-protein kinase erbB2 (Gene symbol = HER2) Swissprot P04626 | rs1801200 (G Allele, heterozygote) | Cardiotoxicity | Beauclair S, Formento P, Fischel JL, Lescaut W, Largillier R, Chamorey E, Hofman P, Ferrero JM, Pages G, Milano G: Role of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of trastuzumab-related cardiotoxicity. Ann Oncol. 2007 Aug;18(8):1335-41. [PubMed] |
| Venlafaxine DB00285 |
Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 | CYP2D6*4 CYP2D6*6 rs5030655 (del T allele) rs3892097 (A allele) | Nausea, vomiting diarrhea | Shams ME, Arneth B, Hiemke C, Dragicevic A, Muller MJ, Kaiser R, Lackner K, Hartter S: CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine. J Clin Pharm Ther. 2006 Oct;31(5):493-502. [PubMed] |