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Displaying adverse reactions 1 - 25 of 82 in total
Drug Interacting Gene/Enzyme SNP RS ID Allele name Defining change Adverse Reaction Reference(s)
Abacavir
DB01048
HLA class I histocompatibility antigen protein P5
Gene symbol: HCP5
UniProt: Q6MZN7
rs2395029 HLA-B*5701G allelePresence of this SNP is predicative of hypersenitivity reaction when abacavir is given to HIV+ patients.18684101
Abciximab
DB00054
Integrin beta-3
Gene symbol: ITGB3
UniProt: P05106
Not AvailableGPIIIa PlA2A2 AlleleAssociated with greater restenosis and risk for subacute coronary thrombosis in patients administered antiplatelet therapy.10732888
Acetylsalicylic acid
DB00945
Leukotriene C4 synthase
Gene symbol: LTC4S
UniProt: Q16873
rs730012 Not AvailableC alleleAspirin-induced urticaria16433794
Acitretin
DB00459
Apolipoprotein E
Gene symbol: APOE
UniProt: P02649
rs429358 Not AvailableC allelePsoriasis16433808
Acitretin
DB00459
Apolipoprotein E
Gene symbol: APOE
UniProt: P02649
rs7412 Not AvailableC allelePsoriasis16433808
Amiodarone
DB01118
Potassium voltage-gated channel subfamily H member 2
Gene symbol: KCNH2
UniProt: Q12809
Not AvailableMiRP1KCNE2Channels formed with mutant MiRP1 subunits and HERG showed slower activation, faster deactivation, and increased drug sensitivity and is associated with cardiac arrhythmia.10219239
Amitriptyline
DB00321
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs1045642 Not AvailableT Allele, homozygousPostural hypotension12082591
Amitriptyline
DB00321
Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261
rs4244285 CYP2C19*2G > AThose with the AA or AG genotype are poor metabolizers of amitriptyline20531370
Amitriptyline
DB00321
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4C > TIncrease risk of side effects and decrease drug metabolism18070221
Amitriptyline
DB00321
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4C > TIncrease risk of side effects and decrease drug metabolism9918137
Azathioprine
DB00993
Thiopurine S-methyltransferase
Gene symbol: TPMT
UniProt: P51580
rs1800462 TMPT*2G AlleleHepatotoxicity16509759
Azathioprine
DB00993
Thiopurine S-methyltransferase
Gene symbol: TPMT
UniProt: P51580
rs1800460 TMPT*3AA AlleleHepatotoxicity16509759
Azathioprine
DB00993
Thiopurine S-methyltransferase
Gene symbol: TPMT
UniProt: P51580
rs1142345 TMPT*3CG AlleleHepatotoxicity16509759
Azathioprine
DB00993
Thiopurine S-methyltransferase
Gene symbol: TPMT
UniProt: P51580
rs1142345 TPMT*3CT > CPatients with CC or CT genotype have decreased inactivation of thiopurines and increased risk of toxicity22846425
Azathioprine
DB00993
Thiopurine S-methyltransferase
Gene symbol: TPMT
UniProt: P51580
rs1142345 TPMT*3CT > CPatients with CC or CT genotype have decreased inactivation of thiopurines and increased risk of toxicity9103127
Caffeine
DB00201
Cytochrome P450 1A2
Gene symbol: CYP1A2
UniProt: P05177
rs762551 Not AvailableC alleleMyocardial infarction16522833
Carbamazepine
DB00564
Heat shock 70 kDa protein 1-like
Gene symbol: HSPA1L
UniProt: P34931
rs2227956 Not AvailableT alleleHypersensitivity reaction, mild erythematous skin rashes, macropapular eruption, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis16538175
Carbamazepine
DB00564
Heat shock 70 kDa protein 1A/1B
Gene symbol: HSPA1A
UniProt: P08107
rs506770 Not AvailableC alleleHypersensitivity reaction, mild erythematous skin rashes, macropapular eruption, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis16538175
Carbamazepine
DB00564
Heat shock 70 kDa protein 1A/1B
Gene symbol: HSPA1A
UniProt: P08107
rs1043620 Not AvailableC alleleHypersensitivity reaction, mild erythematous skin rashes, macropapular eruption, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis16538175
Carbamazepine
DB00564
HLA class I histocompatibility antigen, B-15 alpha chain
Gene symbol: HLA-B
UniProt: P30464
rs3130690 Not AvailableT alleleStevens-Johnson syndrome (SJS), toxic epidermal necrolysis16538176
Carbamazepine
DB00564
HLA class I histocompatibility antigen, A-31 alpha chain
Gene symbol: HLA-A
UniProt: P16189
rs1264511 Not AvailableG alleleMacropapular eruption16538176
Carbamazepine
DB00564
Promotilin
Gene symbol: MLN
UniProt: P12872
rs2894342 Not AvailableA alleleHypersensitivity syndrome16538176
Carbamazepine
DB00564
Flotillin-1
Gene symbol: FLOT1
UniProt: O75955
rs3909184 HLA-B*1502G > CPatients with the CG or GG genotype (in Asian patients) were at a higher risk of Steven-Johnson Syndrome compared to those with the CC genotype (non-carriers of HLA-b*1502)18637831
Carbamazepine
DB00564
Mucin-21
Gene symbol: MUC21
UniProt: Q5SSG8
rs2844682 HLA-B*1502G>APatients with the AG or GG genotype (in Asian patients) were at a higher risk of Steven-Johnson Syndrome compared to those with the AA genotype18637831
Carbamazepine
DB00564
Flotillin-1
Gene symbol: FLOT1
UniProt: O75955
rs3909184 HLA-B*1502G > CPatients with the CG or GG genotype (in Asian patients) were at a higher risk of Steven-Johnson Syndrome compared to those with the CC genotype (non-carriers of HLA-b*1502)15057820
Displaying adverse reactions 1 - 25 of 82 in total