Geno Browse

Drug Name	Interacting Gene/Enzyme	SNP(s)	Adverse Reaction	Reference(s)
5-Fluororuacil DB00544	Orotate phophoribosyltransferase, Uridine 5'-monophosphate synthase (Gene symbol = OPRT or UMPS) Swissprot P11172	rs1801019 (C Allele)	Neutropenia, diarrhea	Ichikawa W, Takahashi T, Suto K, Sasaki Y, Hirayama R: Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen. Clin Cancer Res. 2006 Jul 1;12(13):3928-34. [16818689 ]
5-Fluororuacil DB00544	Thymidylate synthase (Gene symbol = TYMS) Swissprot P04818	TSER*2 rs34743033	Neutropenia, diarrhea	Ichikawa W, Takahashi T, Suto K, Sasaki Y, Hirayama R: Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen. Clin Cancer Res. 2006 Jul 1;12(13):3928-34. [16818689 ]
5-Fluoruracil DB00544	Dihydropyrimidine dehydrogenase (Gene symbol = DPYD) Swissprot Q12882	rs1801265 (C allele) rs1801159 (G allele)	Nausea, vomiting, reduced white cell count	Zhang H, Li YM, Zhang H, Jin X: DPYD*5 gene mutation contributes to the reduced DPYD enzyme activity and chemotherapeutic toxicity of 5-FU: results from genotyping study on 75 gastric carcinoma and colon carcinoma patients. Med Oncol. 2007;24(2):251-8. [17848752 ]
5-Fluoruracil DB00544	Glutathione S-Transferase P1 (Gene symbol = GSTP1) Swissprot P09211	rs1695 (A allele)	Hematological toxicity, gastrointestinal toxicity	Agostini M, Pasetto LM, Pucciarelli S, Terrazzino S, Ambrosi A, Bedin C, Galdi F, Friso ML, Mescoli C, Urso E, Leon A, Lise M, Nitti D: Glutathione S-Transferase P1 Ile105Val Polymorphism is Associated with Haematological Toxicity in Elderly Rectal Cancer Patients Receiving Preoperative Chemoradiotherapy. Drugs Aging. 2008;25(6):531-9. [18540691 ]
5-Fluoruracil DB00544	Dihydropyrimidine dehydrogenase (Gene symbol = DPYD) Swissprot Q12882	rs3918290 (A allele)	Leukopenia, diarrhea, mucositis	Schwab M, Zanger UM, Marx C, Schaeffeler E, Klein K, Dippon J, Kerb R, Blievernicht J, Fischer J, Hofmann U, Bokemeyer C, Eichelbaum M: Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group. J Clin Oncol. 2008 May 1;26(13):2131-8. Epub 2008 Feb 25. [18299612 ]
Acetretin DB00459	Apolipoprotein E (Gene symbol = APOE) Swissprot P02649	rs429358 (C allele) rs7412 (C allele)	Psoriasis	Campalani E, Allen MH, Fairhurst D, Young HS, Mendonca CO, Burden AD, Griffiths CE, Crook MA, Barker JN, Smith CH: Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. Br J Dermatol. 2006 Feb;154(2):345-52. [16433808 ]
Amitriptyline DB00321	Multidrug resistance protein 1 (Gene symbol = ABCB1) Swissprot P08183	rs1045642 (T Allele, homozygous)	Postural hypotension	Roberts RL, Joyce PR, Mulder RT, Begg EJ, Kennedy MA: A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression. Pharmacogenomics J. 2002;2(3):191-6. [12082591 ]
Aspirin DB00945	Leukotriene C4 Synthase (Gene symbol = LTC4S) Swissprot Q16873	rs730012 (C allele)	Aspirin-induced urticaria	Mastalerz L, Setkowicz M, Sanak M, Rybarczyk H, Szczeklik A: Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant. Br J Dermatol. 2006 Feb;154(2):256-60. [16433794 ]
Azathioprine DB00993	Thiopurine S-methyltransferase (Gene symbol = TPMT) Swissprot P51580	TMPT*2 rs1800462 (G Allele)	Hepatotoxicity	Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [16509759 ]
Azathioprine DB00993	Thiopurine S-methyltransferase (Gene symbol = TPMT) Swissprot P51580	TMPT*3A rs1800460 (A Allele)	Hepatotoxicity	Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [16509759 ]
Azathioprine DB00993	Thiopurine S-methyltransferase (Gene symbol = TPMT) Swissprot P51580	TMPT*3C rs1142345 (G Allele)	Hepatotoxicity	Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [16509759 ]
Caffeine DB00201	Cytochrome P450 1A2 (Gene symbol = CYP1A2) Swissprot P05177	rs762551 (C allele)	Myocardial infarction	Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H: Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA. 2006 Mar 8;295(10):1135-41. [16522833 ]
Carbamazepine DB00564	Heat shock 70 kDa protein 1L (gene symbol = HSPA1L) Swissprot P34931	rs2227956 (T allele)	Hypersensitivity reaction, mild erythematous skin rashes, macropapular eruption, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis	Alfirevic A, Mills T, Harrington P, Pinel T, Sherwood J, Jawaid A, Smith JC, March RE, Barratt BJ, Chadwick DW, Kevin Park B, Pirmohamed M: Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. [16538175 ]
Carbamazepine DB00564	Heat shock 70 kDa protein 1 (gene symbol HSPA1A) Swissprot P08107	rs506770 (C allele) rs1043620 (C allele)	Hypersensitivity reaction, mild erythematous skin rashes, macropapular eruption, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis	Alfirevic A, Mills T, Harrington P, Pinel T, Sherwood J, Jawaid A, Smith JC, March RE, Barratt BJ, Chadwick DW, Kevin Park B, Pirmohamed M: Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. [16538175 ]
Carbamazepine DB00564	MHC class I antigen B15, HLA-B1502 (Gene symbol = HLAB) Swissprot P30464	rs3130690 (T allele)	Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis	Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr;16(4):297-306. [16538176 ]
Carbamazepine DB00564	MHC class 1 antigen, A31, HLA-A3101 (Gene symbol = HLAA) Swissprot P16189	rs1264511 (G allele)	Macropapular eruption	Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr;16(4):297-306. [16538176 ]
Carbamazepine DB00564	Motilin (Gene symbol = MLN) Swissprot P12872	rs2894342 (A allele)	Hypersensitivity syndrome	Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr;16(4):297-306. [16538176 ]
Cisplatin DB00515	Megalin, Low-density lipoprotein receptor-related protein 2 (gene symbol = LRP2) Swissprot P98164	rs2075252 (A allele) rs4668123 (T allele)	Ototoxicity (hearing loss)	Riedemann L, Lanvers C, Deuster D, Peters U, Boos J, Jurgens H, am Zehnhoff-Dinnesen A: Megalin genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Pharmacogenomics J. 2008 Feb;8(1):23-8. Epub 2007 Apr 24. [17457342 ]
Cisplatin DB00515	Glutathione S-Transferase P1 (Gene symbol = GSTP1) Swissprot P09211	rs1695 (A allele)	Tinnitus, hearing impairment, Raynaud syndrome	Oldenburg J, Kraggerud SM, Brydoy M, Cvancarova M, Lothe RA, Fossa SD: Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study. J Transl Med. 2007 Dec 27;5:70. [18162130 ]
Cisplatin DB00515	Glutathione S-Transferase Mu 1 (Gene symbol = GSTM1) Swissprot P09488	GSTM1 (presence)	Tinnitus, hearing impairment, Raynaud syndrome	Oldenburg J, Kraggerud SM, Brydoy M, Cvancarova M, Lothe RA, Fossa SD: Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study. J Transl Med. 2007 Dec 27;5:70. [18162130 ]
Citalopram DB00215	cAMP response element-binding protein (Gene symbol = CREB1) Swissprot P16220	rs4675690 (T Allele) rs7569963 (A Allele)	Elevated suicide risk	Perlis RH, Purcell S, Fava M, Fagerness J, Rush AJ, Trivedi MH, Smoller JW: Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study. Arch Gen Psychiatry. 2007 Jun;64(6):689-97. [17548750 ]
Citalopram DB00215	Glutamate receptor 6 (Gene symbol = GRIK2) Swissprot Q13002	rs2518224 (C Allele, homozygote)	Increased suicidal thoughts	Laje G, Paddock S, Manji H, Rush AJ, Wilson AF, Charney D, McMahon FJ: Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. Am J Psychiatry. 2007 Oct;164(10):1530-8. [17898344 ]
Citalopram DB00215	Glutamate receptor 3 (Gene symbol = GRIA3) Swissprot P42263	rs4825476 (G Allele, homozygote)	Increased suicidal thoughts	Laje G, Paddock S, Manji H, Rush AJ, Wilson AF, Charney D, McMahon FJ: Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. Am J Psychiatry. 2007 Oct;164(10):1530-8. [17898344 ]
Coumarin	Cytochrome P450 2A6 (Gene symbol = CYP2A6) Swissprot P11509	CYP2A6*2 rs1801272 (A Allele)	Hepatotoxicity	Farinola N, Piller NB: CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients? Pharmacogenomics. 2007 Feb;8(2):151-8. [17286538 ]
Cyclosporine DB00091	Cytotoxic T-lymphocyte antigen 4 (Gene symbol = CTLA-4) Swissprot P16410	rs231775 (A Allele)	Gingival overgrowth, periodontal disease	Kusztal M, Radwan-Oczko M, Koscielska-Kasprzak K, Boratynska M, Patrzalek D, Klinger M: Possible association of CTLA-4 gene polymorphism with cyclosporine-induced gingival overgrowth in kidney transplant recipients. Transplant Proc. 2007 Nov;39(9):2763-5. [18021981 ]
Daunorubicin DB00694	Cytochrome P450 1B1 (Gene symbol = CYP1B1) Swissprot Q16678	rs10932125 (G allele)	Myelosuppression, cardiac toxicity, cytotoxicty	Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. [18451141 ]
Daunorubicin DB00694	Heterogeneous nuclear ribonucleoprotein D0 (Gene symbol = HNRPD) Swissprot Q14103	rs3750518 (A allele)	Myelosuppression, cardiac toxicity, cytotoxicty	Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. [18451141 ]
Daunorubicin DB00694	Tocopherol-associated protein 2 (Gene symbol = TAP2) Swissprot Q9UDX4	rs6603859 (T allele)	Myelosuppression, cardiac toxicity, cytotoxicty	Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. [18451141 ]
Daunorubicin DB00694	Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Gene symbol = IKBKE) Swissprot Q14164	rs7929521 (A allele)	Myelosuppression, cardiac toxicity, cytotoxicty	Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. [18451141 ]
Docetaxel DB01248	Canalicular multispecific organic anion transporter 1 (Gene symbol = ABCC2) Swissprot Q92887	rs12762549 (G Allele)	Leukopenia, neutropenia	Kiyotani K, Mushiroda T, Kubo M, Zembutsu H, Sugiyama Y, Nakamura Y: Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Cancer Sci. 2008 May;99(5):967-72. Epub 2008 Feb 19. [18294295 ]
Gefitinib DB00317	ATP-binding cassette sub-family G member 2 (Gene symbol ABCG2) Swissprot Q9UNQ0	rs2231142 (A Allele)	Diarrhea	Cusatis G, Gregorc V, Li J, Spreafico A, Ingersoll RG, Verweij J, Ludovini V, Villa E, Hidalgo M, Sparreboom A, Baker SD: Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42. [17148776 ]
Gemcitabine DB00441	Ribonucleotide-diphosphate reductase M1 polypeptide (Gene symbol = RRM1) Swissprot P23921	rs3177016 (A Allele) rs1042858 (G Allele)	Neutropenia	Rha SY, Jeung HC, Choi YH, Yang WI, Yoo JH, Kim BS, Roh JK, Chung HC: An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. Oncologist. 2007 Jun;12(6):622-30. [17602053 ]
Irinotecan DB00762	Solute carrier organic anion transporter family member 1B1 (Gene symbol = SLCO1B1) Swissprot Q9Y6L6	SLCO1B1*15 rs4149056 (C Allele) rs2306283 (G Allele)	Diarrhea, leucopenia, neutropenia	Takane H, Miyata M, Burioka N, Kurai J, Fukuoka Y, Suyama H, Shigeoka Y, Otsubo K, Ieiri I, Shimizu E: Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele. Ther Drug Monit. 2007 Oct;29(5):666-8. [17898662 ]
Irinotecan DB00762	UDP-glucuronosyltransferase 1-1 (Gene symbol = UGT1A1) Swissprot P22309	rs10929302 (A Allele)	Hematological toxicity, neutropenia	Cote JF, Kirzin S, Kramar A, Mosnier JF, Diebold MD, Soubeyran I, Thirouard AS, Selves J, Laurent-Puig P, Ychou M: UGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan. Clin Cancer Res. 2007 Jun 1;13(11):3269-75. Epub 2007 May 17. [17510208 ]
Irinotecan DB00762	UDP-glucuronosyltransferase 1-1 (Gene symbol = UGT1A1) Swissprot P22309	UGT1A1*28 or UGT1A 7/7 rs8175347 (extra TA in promoter)	Leukopenia, thrombpocytopenia	Lankisch TO, Schulz C, Zwingers T, Erichsen TJ, Manns MP, Heinemann V, Strassburg CP: Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):695-701. [18349289 ] Fakih MG, Ross ME, Starostik P: Increased frequency of uridine diphosphate glucuronosyltransferase 1A1 7/7 in patients experiencing severe irinotecan-induced toxicities. Clin Colorectal Cancer. 2007 Jul;6(8):583-7. [17681105 ]
Irinotecan DB00762	UDP-glucuronosyltransferase 1-7 (Gene symbol = UGT1A7) Swissprot Q9HAW7	rs17868323 (G allele) rs17863778 (A allele) rs17868324 (A allele)	Leukopenia, thrombpocytopenia	Lankisch TO, Schulz C, Zwingers T, Erichsen TJ, Manns MP, Heinemann V, Strassburg CP: Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):695-701. [18349289 ]
Isoniazid DB00951	Cytochrome P450 2E1 (Gene symbol = CYP2E1) Swissprot P05181	CYP2E1 *1A rs6413419 (G Allele, homozygote)	Hepatotoxicity	Vuilleumier N, Rossier MF, Chiappe A, Degoumois F, Dayer P, Mermillod B, Nicod L, Desmeules J, Hochstrasser D: CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis. Eur J Clin Pharmacol. 2006 Jun;62(6):423-9. Epub 2006 Apr 27. [16770646 ]
Leflunomide DB01097	Cytochrome P450 1A2 (Gene symbol = CYP1A2) Swissprot P05177	rs762551 (C allele)	Diarrhea, vomiting, liver toxicity, headache, insomnia, rash, alopecia, hypertension, leucopenia, asthma	Bohanec Grabar P, Rozman B, Tomsic M, Suput D, Logar D, Dolzan V: Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients. Eur J Clin Pharmacol. 2008 May 22;. [18496682 ]
Mercaptopurine DB01033	Thiopurine S-methyltransferase (Gene symbol = TPMT) Swissprot P51580	TMPT*2 rs1800462 (G Allele)	Hepatotoxicity	Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [16509759 ]
Mercaptopurine DB01033	Thiopurine S-methyltransferase (Gene symbol = TPMT) Swissprot P51580	TMPT*3A rs1800460 (A Allele)	Hepatotoxicity	Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [16509759 ]
Mercaptopurine DB01033	Thiopurine S-methyltransferase (Gene symbol = TPMT) Swissprot P51580	TMPT*3C rs1142345 (G Allele)	Hepatotoxicity	Bosch TM, Meijerman I, Beijnen JH, Schellens JH: Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. [16509759 ]
Methamphetamine DB01577	PRKCA-binding protein (Gene symbol = PICK1) Swissprot Q9NRD5	rs713729 (T allele) rs2076369 (G allele)	Methamphetamine psychosis and addiction	Matsuzawa D, Hashimoto K, Miyatake R, Shirayama Y, Shimizu E, Maeda K, Suzuki Y, Mashimo Y, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Hata A, Sawa A, Iyo M: Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis. Am J Psychiatry. 2007 Jul;164(7):1105-14. [17606663 ]
Methotrexate DB00563	Methylenetetrahydrofolate reductase (Gene symbol = MTHFR) Swissprot P42898	rs1801133 (T allele)	Mucositis, hepatic toxicity, thrombocytopenia, alopecia	Gemmati D, Ongaro A, Tognazzo S, Catozzi L, Federici F, Mauro E, Della Porta M, Campioni D, Bardi A, Gilli G, Pellati A, Caruso A, Scapoli GL, De Mattei M: Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: association with toxicity and survival. Haematologica. 2007 Apr;92(4):478-85. [17488658 ]
Methotrexate DB00563	Canalicular multispecific organic anion transporter 1 (Gene symbol = ABCC2) Swissprot Q92887	ABCC2 IVS 23+56 (T allele)	General toxicity (gastrointestinal and hepatotoxicity)	Ranganathan P, Culverhouse R, Marsh S, Mody A, Scott-Horton TJ, Brasington R, Joseph A, Reddy V, Eisen S, McLeod HL: Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. J Rheumatol. 2008 Apr;35(4):572-9. Epub 2008 Mar 15. [18381794 ]
Nortryptyline DB00540	Multidrug resistance protein 1 (Gene symbol = ABCB1) Swissprot P08183	rs1045642 (T Allele, homozygous)	Postural hypotension	Roberts RL, Joyce PR, Mulder RT, Begg EJ, Kennedy MA: A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression. Pharmacogenomics J. 2002;2(3):191-6. [12082591 ]
Trastuzumab DB00072	Receptor tyrosine-protein kinase erbB2 (Gene symbol = HER2) Swissprot P04626	rs1801200 (G Allele, heterozygote)	Cardiotoxicity	Beauclair S, Formento P, Fischel JL, Lescaut W, Largillier R, Chamorey E, Hofman P, Ferrero JM, Pages G, Milano G: Role of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of trastuzumab-related cardiotoxicity. Ann Oncol. 2007 Aug;18(8):1335-41. [17693647 ]
Venlafaxine DB00285	Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635	CYP2D64 CYP2D66 rs5030655 (del T allele) rs3892097 (A allele)	Nausea, vomiting diarrhea	Shams ME, Arneth B, Hiemke C, Dragicevic A, Muller MJ, Kaiser R, Lackner K, Hartter S: CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine. J Clin Pharm Ther. 2006 Oct;31(5):493-502. [16958828 ]