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Displaying effects 1 - 25 of 109 in total
Drug Interacting Gene/Enzyme SNP RS ID Allele name Defining change Effect Reference(s)
Acetylsalicylic acid
DB00945
Cytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
rs1057910 CYP2C9*1C AllelePoor drug metabolizer, lower dose requirements12893985
Acetylsalicylic acid
DB00945
Integrin beta-3
Gene symbol: ITGB3
UniProt: P05106
rs5918 Not AvailableT > CPatients are more resistant to the anti-thrombotic effects of aspirin11723016
Afatinib
DB08916
Epidermal growth factor receptor
Gene symbol: EGFR
UniProt: P00533
Not AvailableG719A/C OR (L858R and L861Q)Not AvailableAssociated with enhanced activation of the EGFR tyrosine kinase in patients with non-small cell lung cancer (NSCLC) recieving tyrosine kinase inhibitor therapy.15118073
Almotriptan
DB00918
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Gene symbol: GNB3
UniProt: P16520
rs5443 Not AvailableT AlleleBetter response to drug treatment17361120
Amitriptyline
DB00321
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4A AllelePoor drug metabolizer, lower dose requirements, higher risk for adverse side effects18070221
Amitriptyline
DB00321
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs2032583 Not AvailableC AlleleImproved response to antidepressant medication17913323
Amitriptyline
DB00321
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs2032583 Not AvailableA > GIncrease risk of adverse effects22641028
Amlodipine
DB00381
Natriuretic peptides A
Gene symbol: NPPA
UniProt: P01160
rs5065 Not AvailableAA alleleThose with the rs5065(AA) allele had more favorable cardiovascular disease outcomes if given amlodipine than if treated with chlorthalidone (diuretic)18212314
Atenolol
DB00335
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801253 Not AvailableG > CBetter response to drug therapy22192668
Atorvastatin
DB01076
Kinesin-like protein KIF6
Gene symbol: KIF6
UniProt: Q6ZMV9
rs20455 Not AvailableC AlleleImproved response to statin drugs18222353
Atorvastatin
DB01076
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene symbol: HMGCR
UniProt: P04035
rs17244841 Not AvailableT AlleleReduced response to statin drugs15199031
Atorvastatin
DB01076
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs1045642 MDR1*TT Allele (C3435T)Larger reduction in LDL and smaller increase in HDL cholesterol in females15081455
Bleomycin
DB00290
Bleomycin hydrolase
Gene symbol: BLMH
UniProt: Q13867
rs10500565 Not AvailableA AlleleImproved response to bleomycin18398146
Bleomycin
DB00290
Bleomycin hydrolase
Gene symbol: BLMH
UniProt: Q13867
rs10500565 Not AvailableG AlleleReduced response to bleomycin, higher prevalence of relapse18398146
Budesonide
DB01222
T-box transcription factor TBX21
Gene symbol: TBX21
UniProt: Q9UL17
rs2240017 Not AvailableC AlleleImproved response for long-term asthma treatment15604153
Budesonide
DB01222
T-box transcription factor TBX21
Gene symbol: TBX21
UniProt: Q9UL17
rs2240017 Not AvailableCG allele (heterozygotes)Better response to drug treatment (for asthma) than rs2240017(G;G) homozygotes.15604153
Bupropion
DB01156
D(2) dopamine receptor
Gene symbol: DRD2
UniProt: P14416
rs1800491 Not AvailableC AlleleImproved response in smoking cessation18058343
Carbamazepine
DB00564
Sodium channel protein type 1 subunit alpha
Gene symbol: SCN1A
UniProt: P35498
rs3812718 Not AvailableIVS5N + 5 G>ACarbamazepine resistant therapy, higher maintenance dose24052718
Carvedilol
DB01136
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801253 Not AvailableC AlleleImproved response to blood pressure medication12844134
Carvedilol
DB01136
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801252 Not AvailableA AlleleImproved response to blood pressure medication12844134
Carvedilol
DB01136
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801253 Not AvailableG > CBetter response to drug therapy22192668
Celecoxib
DB00482
Cytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
rs1057910 CYP2C9*1C AllelePoor drug metabolizer, lower dose requirements12893985
Cetuximab
DB00002
Low affinity immunoglobulin gamma Fc region receptor II-a
Gene symbol: FCGR2A
UniProt: P12318
rs1801274 Not AvailableH allelleIncreased progression free survival17704420
Cetuximab
DB00002
Low affinity immunoglobulin gamma Fc region receptor III-A
Gene symbol: FCGR3A
UniProt: P08637
rs396991 Not AvailableA > CBetter response to drug therapy (longer progression free survival) with the F allele17704420
Citalopram
DB00215
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs2032583 Not AvailableC AlleleImproved response to antidepressant medication17913323
Displaying effects 1 - 25 of 109 in total