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Drug Name Interacting Gene/Enzyme SNP(s) Effect Reference(s)
Almotriptan
DB00918 		G protein beta3 subunit (Gene symbol = GNB3) Swissprot P16520 Link_out rs5443 Link_out (T Allele) Better response to drug treatment Schurks M, Kurth T, Stude P, Rimmbach C, de Jesus J, Jonjic M, Diener HC, Rosskopf D: G protein beta3 polymorphism and triptan response in cluster headache. Clin Pharmacol Ther. 2007 Oct;82(4):396-401. Epub 2007 Mar 14. [17361120 Link_out]
Amitriptyline
DB00321 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*4 rs3892097 Link_out (A Allele) Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Bijl MJ, Visser LE, Hofman A, Vulto AG, van Gelder T, Stricker BH, van Schaik RH: Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol. 2008 Apr;65(4):558-64. Epub 2007 Dec 7. [18070221 Link_out]
Amitryptyline
DB00321 		Multidrug resistance protein 1 (Gene symbol = ABCB1) Swissprot P08183 Link_out rs2032583 Link_out (C Allele) Improved response to antidepressant medication Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M, Rosenhagen M, Kohli M, Kloiber S, Salyakina D, Bettecken T, Specht M, Putz B, Binder EB, Muller-Myhsok B, Holsboer F: Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron. 2008 Jan 24;57(2):203-9. [18215618 Link_out]
Kato M, Fukuda T, Serretti A, Wakeno M, Okugawa G, Ikenaga Y, Hosoi Y, Takekita Y, Mandelli L, Azuma J, Kinoshita T: ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):398-404. Epub 2007 Sep 15. [17913323 Link_out]
Aspirin
DB00945 		Cytochrome P450 2C9 (Gene symbol = CYP2C9) Swissprot P11712 Link_out CYP2C9*1 rs1057910 Link_out (C Allele) Poor drug metabolizer, lower dose requirements Kirchheiner J, Stormer E, Meisel C, Steinbach N, Roots I, Brockmoller J: Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites. Pharmacogenetics. 2003 Aug;13(8):473-80. [12893985 Link_out]
Atorvastatin
DB01076 		Kinesin-like protein KIF6 (Gene symbol = KIF6) Swissprot Q6ZMV9 rs20455 Link_out (C Allele) Improved response to statin drugs Iakoubova OA, Tong CH, Rowland CM, Kirchgessner TG, Young BA, Arellano AR, Shiffman D, Sabatine MS, Campos H, Packard CJ, Pfeffer MA, White TJ, Braunwald E, Shepherd J, Devlin JJ, Sacks FM: Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol. 2008 Jan 29;51(4):435-43. [18222353 Link_out]
Atorvastatin
DB01076 		Hydroxy-methylglutaryl-CoA reductase (Gene symbol = HMGCR) Swissprot P04035 Link_out rs17244841 Link_out (T Allele) Reduced response to statin drugs Chasman DI, Posada D, Subrahmanyan L, Cook NR, Stanton VP Jr, Ridker PM: Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA. 2004 Jun 16;291(23):2821-7. [15199031 Link_out]
Bleomycin
DB00290 		Bleomycin hydrolase (Gene symbol = BLMH) Swissprot Q13867 Link_out rs10500565 Link_out (A Allele) Improved response to bleomycin de Haas EC, Zwart N, Meijer C, Nuver J, Boezen HM, Suurmeijer AJ, Hoekstra HJ, van der Steege G, Sleijfer DT, Gietema JA: Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer. J Clin Oncol. 2008 Apr 10;26(11):1817-23. [18398146 Link_out]
Bleomycin
DB00290 		Bleomycin hydrolase (Gene symbol = BLMH) Swissprot Q13867 Link_out rs10500565 Link_out (G Allele) Reduced response to bleomycin, higher prevalence of relapse de Haas EC, Zwart N, Meijer C, Nuver J, Boezen HM, Suurmeijer AJ, Hoekstra HJ, van der Steege G, Sleijfer DT, Gietema JA: Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer. J Clin Oncol. 2008 Apr 10;26(11):1817-23. [18398146 Link_out]
Budesonide
DB01222 		T-box transcription factor TBX21 (Gene symbol = TBX21) Swissprot Q9UL17 rs2240017 Link_out (C Allele) Improved response for long-term asthma treatment Tantisira KG, Hwang ES, Raby BA, Silverman ES, Lake SL, Richter BG, Peng SL, Drazen JM, Glimcher LH, Weiss ST: TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18099-104. Epub 2004 Dec 16. [15604153 Link_out]
Bupropion
DB01156 		Dopamine D2 receptor (Gene symbol = DRD2) Swissprot P14416 Link_out rs1800491 Link_out (C Allele) Improved response in smoking cessation David SP, Strong DR, Munafo MR, Brown RA, Lloyd-Richardson EE, Wileyto PE, Evins EA, Shields PG, Lerman C, Niaura R: Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: analysis of pooled data from two clinical trials. Nicotine Tob Res. 2007 Dec;9(12):1251-7. [18058343 Link_out]
Carvedilol
DB01136 		Beta-1 adrenergic receptor (Gene symbol = ADRB1) Swissprot P08588 Link_out rs1801253 Link_out (C Allele) rs1801252 Link_out (A Allele) Improved response to blood pressure medication Johnson JA, Zineh I, Puckett BJ, McGorray SP, Yarandi HN, Pauly DF: Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther. 2003 Jul;74(1):44-52. [12844134 Link_out]
Celecoxib
DB00482 		Cytochrome P450 2C9 (Gene symbol = CYP2C9) Swissprot P11712 Link_out CYP2C9*1 rs1057910 Link_out (C Allele) Poor drug metabolizer, lower dose requirements Kirchheiner J, Stormer E, Meisel C, Steinbach N, Roots I, Brockmoller J: Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites. Pharmacogenetics. 2003 Aug;13(8):473-80. [12893985 Link_out]
Citalopram
DB00215 		Multidrug resistance protein 1 (Gene symbol = ABCB1) Swissprot P08183 Link_out rs2032583 Link_out (C Allele) Improved response to antidepressant medication Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M, Rosenhagen M, Kohli M, Kloiber S, Salyakina D, Bettecken T, Specht M, Putz B, Binder EB, Muller-Myhsok B, Holsboer F: Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron. 2008 Jan 24;57(2):203-9. [18215618 Link_out]
Kato M, Fukuda T, Serretti A, Wakeno M, Okugawa G, Ikenaga Y, Hosoi Y, Takekita Y, Mandelli L, Azuma J, Kinoshita T: ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):398-404. Epub 2007 Sep 15. [17913323 Link_out]
Citalopram
DB00215 		Serotonin receptor 2A (Gene symbol = HTR2A) Swissprot P28223 Link_out rs7997012 Link_out (A Allele) Improved response to antidepressant medication McMahon FJ, Buervenich S, Charney D, Lipsky R, Rush AJ, Wilson AF, Sorant AJ, Papanicolaou GJ, Laje G, Fava M, Trivedi MH, Wisniewski SR, Manji H: Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. Am J Hum Genet. 2006 May;78(5):804-14. Epub 2006 Mar 20. [16642436 Link_out]
Citalopram
DB00215 		Glutamate receptor KA-1 (Gene symbol = GRIK4) Swissprot Q16099 Link_out rs1954787 Link_out (C Allele) Improved response to antidepressant medication Paddock S, Laje G, Charney D, Rush AJ, Wilson AF, Sorant AJ, Lipsky R, Wisniewski SR, Manji H, McMahon FJ: Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort. Am J Psychiatry. 2007 Aug;164(8):1181-8. [17671280 Link_out]
Clomipramine
DB01242 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*4 rs3892097 Link_out (A Allele) Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Bijl MJ, Visser LE, Hofman A, Vulto AG, van Gelder T, Stricker BH, van Schaik RH: Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol. 2008 Apr;65(4):558-64. Epub 2007 Dec 7. [18070221 Link_out]
Clopidogrel
DB00758 		Cytochrome P450 2C9 (Gene symbol = CYP2C9) Swissprot P11712 Link_out CYP2C9*1 rs1057910 Link_out (C Allele) Poor drug metabolizer, lower dose requirements, higher risk for drug-drug interactions Brandt JT, Close SL, Iturria SJ, Payne CD, Farid NA, Ernest CS 2nd, Lachno DR, Salazar D, Winters KJ: Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J Thromb Haemost. 2007 Dec;5(12):2429-36. Epub 2007 Sep 26. [17900275 Link_out]
Clopidogrel
DB00758 		Cytochrome P450 2C19 (Gene symbol = CYP2C19) Swissprot P33261 Link_out CYP2C19*2 rs4244285 Link_out (A Allele, homozygote) Poor drug metabolizer, lower dose requirements, higher risk for drug-drug interactions Brandt JT, Close SL, Iturria SJ, Payne CD, Farid NA, Ernest CS 2nd, Lachno DR, Salazar D, Winters KJ: Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J Thromb Haemost. 2007 Dec;5(12):2429-36. Epub 2007 Sep 26. [17900275 Link_out]
Codeine
DB00318 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*4 rs3892097 Link_out (A Allele, homozygote) Poor drug metabolizer, lower dose requirements Desmeules J, Gascon MP, Dayer P, Magistris M: Impact of environmental and genetic factors on codeine analgesia. Eur J Clin Pharmacol. 1991;41(1):23-6. [1782973 Link_out]
Codeine
DB00318 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*6 rs5030655 Link_out (T deletion, homozygote) Poor drug metabolizer, lower dose requirements Desmeules J, Gascon MP, Dayer P, Magistris M: Impact of environmental and genetic factors on codeine analgesia. Eur J Clin Pharmacol. 1991;41(1):23-6. [1782973 Link_out]
Codeine
DB00318 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*5 (Deletion, homozygote) Poor drug metabolizer, lower dose requirements Desmeules J, Gascon MP, Dayer P, Magistris M: Impact of environmental and genetic factors on codeine analgesia. Eur J Clin Pharmacol. 1991;41(1):23-6. [1782973 Link_out]
Desipramine
DB01151 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*4 rs3892097 Link_out (A Allele) Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Bijl MJ, Visser LE, Hofman A, Vulto AG, van Gelder T, Stricker BH, van Schaik RH: Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol. 2008 Apr;65(4):558-64. Epub 2007 Dec 7. [18070221 Link_out]
Dextromethorphan
DB00514 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*4 rs3892097 Link_out (A Allele, homozygote) Poor drug metabolizer, lower dose requirements Bradford LD, Gaedigk A, Leeder JS: High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data. Psychopharmacol Bull. 1998;34(4):797-804. [10513455 Link_out]
Dextromethorphan
DB00514 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*6 rs5030655 Link_out (T deletion, homozygote) Poor drug metabolizer, lower dose requirements Bradford LD, Gaedigk A, Leeder JS: High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data. Psychopharmacol Bull. 1998;34(4):797-804. [10513455 Link_out]
Eletriptan
DB00216 		G protein beta3 subunit (Gene symbol = GNB3) Swissprot P16520 Link_out rs5443 Link_out (T Allele) Better response to drug treatment Schurks M, Kurth T, Stude P, Rimmbach C, de Jesus J, Jonjic M, Diener HC, Rosskopf D: G protein beta3 polymorphism and triptan response in cluster headache. Clin Pharmacol Ther. 2007 Oct;82(4):396-401. Epub 2007 Mar 14. [17361120 Link_out]
Esomeprazole
DB00736 		Cytochrome P450 2C19 (Gene symbol = CYP2C19) Swissprot P33261 Link_out CYP2C19*2 rs4244285 Link_out (A Allele, homozygote) Poor metabolizer, lower dose requirement, improved drug efficacy Furuta T, Ohashi K, Kamata T, Takashima M, Kosuge K, Kawasaki T, Hanai H, Kubota T, Ishizaki T, Kaneko E: Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med. 1998 Dec 15;129(12):1027-30. [9867757 Link_out]
Esomeprazole
DB00736 		Cytochrome P450 2C19 (Gene symbol = CYP2C19) Swissprot P33261 Link_out CYP2C19*3 rs4986893 Link_out (A Allele, homozygote) Poor metabolizer, lower dose requirement, improved drug efficacy Furuta T, Ohashi K, Kamata T, Takashima M, Kosuge K, Kawasaki T, Hanai H, Kubota T, Ishizaki T, Kaneko E: Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med. 1998 Dec 15;129(12):1027-30. [9867757 Link_out]
Frovatriptan
DB00998 		G protein beta3 subunit (Gene symbol = GNB3) Swissprot P16520 Link_out rs5443 Link_out (T Allele) Better response to drug treatment Schurks M, Kurth T, Stude P, Rimmbach C, de Jesus J, Jonjic M, Diener HC, Rosskopf D: G protein beta3 polymorphism and triptan response in cluster headache. Clin Pharmacol Ther. 2007 Oct;82(4):396-401. Epub 2007 Mar 14. [17361120 Link_out]
Glipizide
DB01067 		Cytochrome P450 2C9 (Gene symbol = CYP2C9) Swissprot P11712 Link_out CYP2C9*1 rs1057910 Link_out (C Allele) Poor drug metabolizer, lower dose requirements Kidd RS, Straughn AB, Meyer MC, Blaisdell J, Goldstein JA, Dalton JT: Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele. Pharmacogenetics. 1999 Feb;9(1):71-80. [10208645 Link_out]
Imipramine
DB00458 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*4 rs3892097 Link_out (A Allele) Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Bijl MJ, Visser LE, Hofman A, Vulto AG, van Gelder T, Stricker BH, van Schaik RH: Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol. 2008 Apr;65(4):558-64. Epub 2007 Dec 7. [18070221 Link_out]
Lansoprazole
DB00448 		Cytochrome P450 2C19 (Gene symbol = CYP2C19) Swissprot P33261 Link_out CYP2C19*2 rs4244285 Link_out (A Allele, homozygote) Poor metabolizer, lower dose requirement, improved drug efficacy Furuta T, Ohashi K, Kamata T, Takashima M, Kosuge K, Kawasaki T, Hanai H, Kubota T, Ishizaki T, Kaneko E: Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med. 1998 Dec 15;129(12):1027-30. [9867757 Link_out]
Lansoprazole
DB00448 		Cytochrome P450 2C19 (Gene symbol = CYP2C19) Swissprot P33261 Link_out CYP2C19*3 rs4986893 Link_out (A Allele, homozygote) Poor metabolizer, lower dose requirement, improved drug efficacy Furuta T, Ohashi K, Kamata T, Takashima M, Kosuge K, Kawasaki T, Hanai H, Kubota T, Ishizaki T, Kaneko E: Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med. 1998 Dec 15;129(12):1027-30. [9867757 Link_out]
Mephenytoin
DB00532 		Cytochrome P450 2C19 (Gene symbol = CYP2C19) Swissprot P33261 Link_out CYP2C19*3 rs4986893 Link_out (A Allele, homozygote) Poor metabolizer, lower dose requirement De Morais SM, Wilkinson GR, Blaisdell J, Meyer UA, Nakamura K, Goldstein JA: Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol. 1994 Oct;46(4):594-8. [7969038 Link_out]
Metoprolol
DB00264 		Beta-1 adrenergic receptor (Gene symbol = ADRB1) Swissprot P08588 Link_out rs1801253 Link_out (C Allele) rs1801252 Link_out (A Allele) Improved response to blood pressure medication Johnson JA, Zineh I, Puckett BJ, McGorray SP, Yarandi HN, Pauly DF: Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther. 2003 Jul;74(1):44-52. [12844134 Link_out]
Morphine
DB00295 		Multidrug resistance protein 1 (Gene symbol = ABCB1) Swissprot P08183 Link_out rs1045642 Link_out (T Allele) Better response to pain relief drugs Campa D, Gioia A, Tomei A, Poli P, Barale R: Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief. Clin Pharmacol Ther. 2008 Apr;83(4):559-66. Epub 2007 Sep 26. [17898703 Link_out]
Morphine
DB00295 		Mu-type opioid receptor (Gene symbol = OPRM1) Swissprot P35372 Link_out rs1799971 Link_out (A Allele) Better response to pain relief drugs Campa D, Gioia A, Tomei A, Poli P, Barale R: Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief. Clin Pharmacol Ther. 2008 Apr;83(4):559-66. Epub 2007 Sep 26. [17898703 Link_out]
Naratriptan
DB00952 		G protein beta3 subunit (Gene symbol = GNB3) Swissprot P16520 Link_out rs5443 Link_out (T Allele) Better response to drug treatment Schurks M, Kurth T, Stude P, Rimmbach C, de Jesus J, Jonjic M, Diener HC, Rosskopf D: G protein beta3 polymorphism and triptan response in cluster headache. Clin Pharmacol Ther. 2007 Oct;82(4):396-401. Epub 2007 Mar 14. [17361120 Link_out]
Nortriptyline
DB00540 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*4 rs3892097 Link_out (A Allele) Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Bijl MJ, Visser LE, Hofman A, Vulto AG, van Gelder T, Stricker BH, van Schaik RH: Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol. 2008 Apr;65(4):558-64. Epub 2007 Dec 7. [18070221 Link_out]
Omeprazole
DB00338 		Cytochrome P450 2C19 (Gene symbol = CYP2C19) Swissprot P33261 Link_out CYP2C19*2 rs4244285 Link_out (A Allele, homozygote) Poor metabolizer, lower dose requirement, improved drug efficacy Furuta T, Ohashi K, Kamata T, Takashima M, Kosuge K, Kawasaki T, Hanai H, Kubota T, Ishizaki T, Kaneko E: Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med. 1998 Dec 15;129(12):1027-30. [9867757 Link_out]
Omeprazole
DB00338 		Cytochrome P450 2C19 (Gene symbol = CYP2C19) Swissprot P33261 Link_out CYP2C19*3 rs4986893 Link_out (A Allele, homozygote) Poor metabolizer, lower dose requirement, improved drug efficacy Furuta T, Ohashi K, Kamata T, Takashima M, Kosuge K, Kawasaki T, Hanai H, Kubota T, Ishizaki T, Kaneko E: Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med. 1998 Dec 15;129(12):1027-30. [9867757 Link_out]
Paroxetine
DB00715 		Multidrug resistance protein 1 (Gene symbol = ABCB1) Swissprot P08183 Link_out rs2032583 Link_out (C Allele) Improved response to antidepressant medication Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M, Rosenhagen M, Kohli M, Kloiber S, Salyakina D, Bettecken T, Specht M, Putz B, Binder EB, Muller-Myhsok B, Holsboer F: Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron. 2008 Jan 24;57(2):203-9. [18215618 Link_out]
Kato M, Fukuda T, Serretti A, Wakeno M, Okugawa G, Ikenaga Y, Hosoi Y, Takekita Y, Mandelli L, Azuma J, Kinoshita T: ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):398-404. Epub 2007 Sep 15. [17913323 Link_out]
Phenytoin
DB00252 		Cytochrome P450 2C9 (Gene symbol = CYP2C9) Swissprot P11712 Link_out CYP2C9*1 rs1057910 Link_out (C Allele) Poor drug metabolizer, lower dose requirements Tate SK, Depondt C, Sisodiya SM, Cavalleri GL, Schorge S, Soranzo N, Thom M, Sen A, Shorvon SD, Sander JW, Wood NW, Goldstein DB: Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5507-12. Epub 2005 Apr 1. [15805193 Link_out]
Pravastatin
DB00175 		Kinesin-like protein KIF6 (Gene symbol = KIF6) Swissprot Q6ZMV9 rs20455 Link_out (C Allele) Improved response to statin drugs Iakoubova OA, Tong CH, Rowland CM, Kirchgessner TG, Young BA, Arellano AR, Shiffman D, Sabatine MS, Campos H, Packard CJ, Pfeffer MA, White TJ, Braunwald E, Shepherd J, Devlin JJ, Sacks FM: Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol. 2008 Jan 29;51(4):435-43. [18222353 Link_out]
Pravastatin
DB00175 		Hydroxy-methylglutaryl-CoA reductase (Gene symbol = HMGCR) Swissprot P04035 Link_out rs17244841 Link_out (T Allele) Reduced response to statin drugs Chasman DI, Posada D, Subrahmanyan L, Cook NR, Stanton VP Jr, Ridker PM: Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA. 2004 Jun 16;291(23):2821-7. [15199031 Link_out]
Proguanil
DB01131 		Cytochrome P450 2C19 (Gene symbol = CYP2C19) Swissprot P33261 Link_out CYP2C19*2 rs4244285 Link_out (A Allele, homozygote) Poor metabolizer, lower dose requirement Hoskins JM, Shenfield GM, Gross AS: Concordance between proguanil phenotype and CYP2C19 genotype in Chinese. Eur J Clin Pharmacol. 2003 Nov;59(8-9):611-4. Epub 2003 Sep 12. [13680037 Link_out]
Proguanil
DB01131 		Cytochrome P450 2C19 (Gene symbol = CYP2C19) Swissprot P33261 Link_out CYP2C19*3 rs4986893 Link_out (A Allele, homozygote) Poor metabolizer, lower dose requirement Hoskins JM, Shenfield GM, Gross AS: Concordance between proguanil phenotype and CYP2C19 genotype in Chinese. Eur J Clin Pharmacol. 2003 Nov;59(8-9):611-4. Epub 2003 Sep 12. [13680037 Link_out]
Ramipril
DB00178 		Angiotensin converting enzyme (Gene symbol = ACE) Swissprot P12821 Link_out rs4344 Link_out (A Allele, homozygote) More rapid response to drug treatment Bhatnagar V, O'Connor DT, Schork NJ, Salem RM, Nievergelt CM, Rana BK, Smith DW, Bakris GL, Middleton JP, Norris KC, Wright JT, Cheek D, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS: Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial. J Hypertens. 2007 Oct;25(10):2082-92. [17885551 Link_out]
Ramipril
DB00178 		Angiotensin converting enzyme (Gene symbol = ACE) Swissprot P12821 Link_out rs4344 Link_out (G Allele, homozygote) More rapid response to drug treatment Bhatnagar V, O'Connor DT, Schork NJ, Salem RM, Nievergelt CM, Rana BK, Smith DW, Bakris GL, Middleton JP, Norris KC, Wright JT, Cheek D, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS: Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial. J Hypertens. 2007 Oct;25(10):2082-92. [17885551 Link_out]
Rizatriptan
DB00953 		G protein beta3 subunit (Gene symbol = GNB3) Swissprot P16520 Link_out rs5443 Link_out (T Allele) Better response to drug treatment Schurks M, Kurth T, Stude P, Rimmbach C, de Jesus J, Jonjic M, Diener HC, Rosskopf D: G protein beta3 polymorphism and triptan response in cluster headache. Clin Pharmacol Ther. 2007 Oct;82(4):396-401. Epub 2007 Mar 14. [17361120 Link_out]
Rosuvastatin
DB01098 		Kinesin-like protein KIF6 (Gene symbol = KIF6) Swissprot Q6ZMV9 rs20455 Link_out (C Allele) Improved response to statin drugs Iakoubova OA, Tong CH, Rowland CM, Kirchgessner TG, Young BA, Arellano AR, Shiffman D, Sabatine MS, Campos H, Packard CJ, Pfeffer MA, White TJ, Braunwald E, Shepherd J, Devlin JJ, Sacks FM: Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol. 2008 Jan 29;51(4):435-43. [18222353 Link_out]
Rosuvastatin
DB01098 		Hydroxy-methylglutaryl-CoA reductase (Gene symbol = HMGCR) Swissprot P04035 Link_out rs17244841 Link_out (T Allele) Reduced response to statin drugs Chasman DI, Posada D, Subrahmanyan L, Cook NR, Stanton VP Jr, Ridker PM: Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA. 2004 Jun 16;291(23):2821-7. [15199031 Link_out]
Sildenafil
DB00203 		Angiotensin converting enzyme (Gene symbol = ACE) Swissprot P12821 Link_out Alu insertions rs1799752 Link_out + rs4340 Link_out + rs13447447 Link_out + rs4646994 Link_out Better response to drug treatment Eisenhardt A, Sperling H, Hauck E, Porst H, Stief C, Rubben H, Muller N, Siffert W: ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction. Urology. 2003 Jul;62(1):152-7. [12837457 Link_out]
Sildenafil
DB00203 		G protein beta3 subunit (Gene symbol = GNB3) Swissprot P16520 Link_out rs5443 Link_out (T Allele) Better response to drug treatment Sperling H, Eisenhardt A, Virchow S, Hauck E, Lenk S, Porst H, Stief C, Wetterauer U, Rubben H, Muller N, Siffert W: Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: a pilot study. J Urol. 2003 Mar;169(3):1048-51. [12576843 Link_out]
Simvastatin
DB00641 		Kinesin-like protein KIF6 (Gene symbol = KIF6) Swissprot Q6ZMV9 rs20455 Link_out (C Allele) Improved response to statin drugs Iakoubova OA, Tong CH, Rowland CM, Kirchgessner TG, Young BA, Arellano AR, Shiffman D, Sabatine MS, Campos H, Packard CJ, Pfeffer MA, White TJ, Braunwald E, Shepherd J, Devlin JJ, Sacks FM: Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol. 2008 Jan 29;51(4):435-43. [18222353 Link_out]
Simvastatin
DB00641 		Hydroxy-methylglutaryl-CoA reductase (Gene symbol = HMGCR) Swissprot P04035 Link_out rs17244841 Link_out (T Allele) Reduced response to statin drugs Chasman DI, Posada D, Subrahmanyan L, Cook NR, Stanton VP Jr, Ridker PM: Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA. 2004 Jun 16;291(23):2821-7. [15199031 Link_out]
Sumatriptan
DB00669 		G protein beta3 subunit (Gene symbol = GNB3) Swissprot P16520 Link_out rs5443 Link_out (T Allele) Better response to drug treatment Schurks M, Kurth T, Stude P, Rimmbach C, de Jesus J, Jonjic M, Diener HC, Rosskopf D: G protein beta3 polymorphism and triptan response in cluster headache. Clin Pharmacol Ther. 2007 Oct;82(4):396-401. Epub 2007 Mar 14. [17361120 Link_out]
Tamoxifen
DB00675 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*4 rs3892097 Link_out (A Allele, homozygote) Poor response to drug treatment, shorter time to relapse Goetz MP, Knox SK, Suman VJ, Rae JM, Safgren SL, Ames MM, Visscher DW, Reynolds C, Couch FJ, Lingle WL, Weinshilboum RM, Fritcher EG, Nibbe AM, Desta Z, Nguyen A, Flockhart DA, Perez EA, Ingle JN: The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat. 2007 Jan;101(1):113-21. Epub 2006 Nov 18. [17115111 Link_out]
Theophylline
DB00277 		Cytochrome P450 1A2 (Gene symbol = CYP1A2) Swissprt P05177 Link_out -2964G>A (A Allele) Poor metabolizer, lower dose requirement Obase Y, Shimoda T, Kawano T, Saeki S, Tomari SY, Mitsuta-Izaki K, Matsuse H, Kinoshita M, Kohno S: Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma. Clin Pharmacol Ther. 2003 May;73(5):468-74. [12732846 Link_out]
Tolbutamide
DB01124 		Cytochrome P450 2C9 (Gene symbol = CYP2C9) Swissprot P11712 Link_out CYP2C9*1 rs1057910 Link_out (C Allele) Poor drug metabolizer, lower dose requirements Sullivan-Klose TH, Ghanayem BI, Bell DA, Zhang ZY, Kaminsky LS, Shenfield GM, Miners JO, Birkett DJ, Goldstein JA: The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics. 1996 Aug;6(4):341-9. [8873220 Link_out]
Trastuzumab
DB00072 		Fibroblast growth factor receptor 4 (Gene symbol = FGFR4) Swissprot P22455 Link_out rs351855 Link_out (C Allele) Reduced response to herceptin Thussbas C, Nahrig J, Streit S, Bange J, Kriner M, Kates R, Ulm K, Kiechle M, Hoefler H, Ullrich A, Harbeck N: FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer. J Clin Oncol. 2006 Aug 10;24(23):3747-55. Epub 2006 Jul 5. [16822847 Link_out]
Venlafaxine
DB00285 		Multidrug resistance protein 1 (Gene symbol = ABCB1) Swissprot P08183 Link_out rs2032583 Link_out (C Allele) Improved response to antidepressant medication Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M, Rosenhagen M, Kohli M, Kloiber S, Salyakina D, Bettecken T, Specht M, Putz B, Binder EB, Muller-Myhsok B, Holsboer F: Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron. 2008 Jan 24;57(2):203-9. [18215618 Link_out]
Kato M, Fukuda T, Serretti A, Wakeno M, Okugawa G, Ikenaga Y, Hosoi Y, Takekita Y, Mandelli L, Azuma J, Kinoshita T: ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):398-404. Epub 2007 Sep 15. [17913323 Link_out]
Venlafaxine
DB00285 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*4 rs3892097 Link_out (A Allele) CYP2D6*6 rs5030655 Link_out (T deletion) Poor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea Shams ME, Arneth B, Hiemke C, Dragicevic A, Muller MJ, Kaiser R, Lackner K, Hartter S: CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine. J Clin Pharm Ther. 2006 Oct;31(5):493-502. [16958828 Link_out]
Venlafaxine
DB00285 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*6 rs5030655 Link_out (T deletion, homozygote) Poor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea Shams ME, Arneth B, Hiemke C, Dragicevic A, Muller MJ, Kaiser R, Lackner K, Hartter S: CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine. J Clin Pharm Ther. 2006 Oct;31(5):493-502. [16958828 Link_out]
Venlafaxine
DB00285 		Cytochrome P450 2D6 (Gene symbol = CYP2D6) Swissprot P10635 Link_out CYP2D6*5 (Deletion) CYP2D6*4 rs3892097 Link_out (A Allele) Poor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea Shams ME, Arneth B, Hiemke C, Dragicevic A, Muller MJ, Kaiser R, Lackner K, Hartter S: CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine. J Clin Pharm Ther. 2006 Oct;31(5):493-502. [16958828 Link_out]
Warfarin
DB00682 		Cytochrome P450 2C9 (Gene symbol = CYP2C9) Swissprot P11712 Link_out CYP2C9*2 rs1799853 Link_out (T Allele) Poor drug metabolizer, lower dose requirements King BP, Khan TI, Aithal GP, Kamali F, Daly AK: Upstream and coding region CYP2C9 polymorphisms: correlation with warfarin dose and metabolism. Pharmacogenetics. 2004 Dec;14(12):813-22. [15608560 Link_out]
Zolmitriptan
DB00315 		G protein beta3 subunit (Gene symbol = GNB3) Swissprot P16520 Link_out rs5443 Link_out (T Allele) Better response to drug treatment Schurks M, Kurth T, Stude P, Rimmbach C, de Jesus J, Jonjic M, Diener HC, Rosskopf D: G protein beta3 polymorphism and triptan response in cluster headache. Clin Pharmacol Ther. 2007 Oct;82(4):396-401. Epub 2007 Mar 14. [17361120 Link_out]