Microscopic Polyangiitis
Also known as: Microscopic Polyangiitis (MPA) / Microscopic polyangiitis (disorder)
| Drug | Drug Name | Drug Description |
|---|---|---|
| DB15011 | Avacopan | An orally bioavailable complement 5a receptor (C5aR) antagonist for the treatment of severe anti-neutrophil cytoplasmic (auto)antibody (ANCA)-associated vasculitis. |
| DB00073 | Rituximab | A monoclonal anti-CD20 antibody used to treat non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Wegener's granulomatosis, pemphigus vulgaris, and rheumatoid arthritis. |
| Drug | Drug Name | Target | Type |
|---|---|---|---|
| DB15011 | Avacopan | C5a anaphylatoxin chemotactic receptor 1 | target |
| DB15011 | Avacopan | Cytochrome P450 3A4 | enzyme |
| DB15011 | Avacopan | P-glycoprotein 1 | transporter |
| DB15011 | Avacopan | Cytochrome P450 1A2 | enzyme |
| DB15011 | Avacopan | Cytochrome P450 2B6 | enzyme |
| DB15011 | Avacopan | Cytochrome P450 2C9 | enzyme |
| DB00073 | Rituximab | B-lymphocyte antigen CD20 | target |