Respiratory Depression

Also known as: Lung function decreased / Lung function decreased (NOS) / Function pulmonary decreased / Respiration depressed / Depression respiratory / Decreased respiratory function (finding)

Drug	Drug Name	Drug Description
DB00201	Caffeine	A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
DB01010	Edrophonium	A cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis.
DB01183	Naloxone	An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.

Drug	Drug Name	Target	Type
DB00201	Caffeine	Adenosine receptor A1	target
DB00201	Caffeine	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	target
DB00201	Caffeine	Adenosine receptor A2a	target
DB00201	Caffeine	Cytochrome P450 1A2	enzyme
DB00201	Caffeine	Ryanodine receptor 1	target
DB00201	Caffeine	Cytochrome P450 3A4	enzyme
DB00201	Caffeine	Cytochrome P450 2E1	enzyme
DB00201	Caffeine	Cytochrome P450 2C8	enzyme
DB00201	Caffeine	Cytochrome P450 2C9	enzyme
DB00201	Caffeine	Cytochrome P450 1A1	enzyme
DB00201	Caffeine	Cytochrome P450 1B1	enzyme
DB00201	Caffeine	Cytochrome P450 2D6	enzyme
DB00201	Caffeine	Cyclic nucleotide phosphodiesterase	target
DB00201	Caffeine	DNA-dependent protein kinase catalytic subunit	target
DB00201	Caffeine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	target
DB00201	Caffeine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	target
DB00201	Caffeine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	target
DB00201	Caffeine	Inositol 1,4,5-trisphosphate receptor	target
DB00201	Caffeine	Serine-protein kinase ATM	target
DB00201	Caffeine	ATP-binding cassette sub-family G member 2	transporter
DB00201	Caffeine	Adenosine receptor A2b	target
DB00201	Caffeine	Adenosine receptor A3	target
DB00201	Caffeine	Phosphodiesterase enzymes	target
DB01010	Edrophonium	Acetylcholinesterase	target
DB01010	Edrophonium	Cholinesterase	target
DB01183	Naloxone	Mu-type opioid receptor	target
DB01183	Naloxone	Estrogen receptor alpha	target
DB01183	Naloxone	Cyclic AMP-responsive element-binding protein 1	target
DB01183	Naloxone	Delta-type opioid receptor	target
DB01183	Naloxone	Solute carrier organic anion transporter family member 1A2	transporter
DB01183	Naloxone	P-glycoprotein 1	transporter
DB01183	Naloxone	Kappa-type opioid receptor	target
DB01183	Naloxone	Cytochrome P450 3A4	enzyme
DB01183	Naloxone	Serum albumin	carrier
DB01183	Naloxone	Toll-like receptor 4	target
DB01183	Naloxone	Liver carboxylesterase 1	target
DB01183	Naloxone	UDP-glucuronosyltransferase 1-1	enzyme
DB01183	Naloxone	Cytochrome P450 2C18	enzyme
DB01183	Naloxone	Cytochrome P450 2C19	enzyme

Drug	Drug Name	Phase	Status	Count
DB00921	Buprenorphine	1	Completed	1
DB09157	Carbon dioxide	1	Completed	1
DB00497	Oxycodone	1	Completed	1
DB09140	Oxygen	1	Completed	1
DB00899	Remifentanil	1	Completed	2
DB00633	Dexmedetomidine	1 / 2	Completed	1
DB18153	ENA-001	2	Not Yet Recruiting	1
DB00295	Morphine	2	Active Not Recruiting	1
DB00295	Morphine	2 / 3	Active Not Recruiting	1
DB00899	Remifentanil	2 / 3	Recruiting	1
DB00316	Acetaminophen	3	Completed	1
DB01234	Dexamethasone	3	Completed	1
DB00633	Dexmedetomidine	3	Completed	1
DB00813	Fentanyl	3	Completed	2
DB00996	Gabapentin	3	Completed	1
DB01221	Ketamine	3	Completed	1
DB00281	Lidocaine	3	Completed	1
DB00904	Ondansetron	3	Completed	1
DB01236	Sevoflurane	3	Completed	1
DB14009	Medical Cannabis	4	Recruiting	1
DB01183	Naloxone	4	Completed	1
DB14881	Oliceridine	4	Completed	1
DB00296	Ropivacaine	4	Completed	1
DB00813	Fentanyl	Not Available	Active Not Recruiting	1
DB00813	Fentanyl	Not Available	Completed	1
DB00813	Fentanyl	Not Available	Withdrawn	1
DB00327	Hydromorphone	Not Available	Terminated	1
DB01221	Ketamine	Not Available	Completed	1
DB00295	Morphine	Not Available	Terminated	1
DB00295	Morphine	Not Available	Unknown Status	1