Active Psoriatic arthritis

Also known as: Psoriatic arthritis aggravated / Psoriatic arthropathy aggravated / Psoriatic arthropathy NOS (disorder) / Psoriatic arthropathy / Arthropathy psoriatic / Psoriatic arthritis / Psoriasis with arthropathy (disorder) / Arthritis, Psoriatic / Psoriatic arthropathies / Arthropathic psoriasis / Arthropathic psoriasis, unspecified

Drug	Drug Name	Drug Description
DB05676	Apremilast	A non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis.
DB08904	Certolizumab pegol	A tumor necrosis factor (TNF) blocker used to treat a variety of autoimmune and autoinflammatory conditions like Crohn's disease, rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, axial spondyloarthritis, and plaque psoriasis.
DB06674	Golimumab	A TNFα inhibitor used in the symptomatic treatment of various active inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis.
DB11569	Ixekizumab	A monoclonal antibody used to treat moderate to severe plaque psoriasis.
DB14762	Risankizumab	An interleukin-23 antagonist used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease in adults.
DB09029	Secukinumab	An immunomodulating agent and interleukin antagonist used to manage plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, along with other joint inflammatory disorders.
DB15091	Upadacitinib	An oral Janus kinase (JAK)1-selective inhibitor used in the treatment of moderate to severe rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, and severe atopic dermatitis, including in patients who did not respond well to other therapies.
DB05679	Ustekinumab	A targeted antibody therapy used to manage inflammatory conditions such as plaque psoriasis, psoriatic arthritis, Crohn's Disease, and ulcerative colitis.

Drug	Drug Name	Target	Type
DB05676	Apremilast	Phosphodiesterase isozyme 4	target
DB05676	Apremilast	Cytochrome P450 3A4	enzyme
DB05676	Apremilast	Cytochrome P450 2A6	enzyme
DB05676	Apremilast	Cytochrome P450 1A2	enzyme
DB05676	Apremilast	P-glycoprotein 1	transporter
DB08904	Certolizumab pegol	Tumor necrosis factor	target
DB08904	Certolizumab pegol	Alcohol dehydrogenase [NADP(+)]	enzyme
DB06674	Golimumab	Tumor necrosis factor	target
DB11569	Ixekizumab	Interleukin-17A	target
DB14762	Risankizumab	Interleukin-23	target
DB09029	Secukinumab	Interleukin-17A	target
DB15091	Upadacitinib	Tyrosine-protein kinase JAK1	target
DB15091	Upadacitinib	Cytochrome P450 3A4	enzyme
DB15091	Upadacitinib	Cytochrome P450 2D6	enzyme
DB15091	Upadacitinib	P-glycoprotein 1	transporter
DB15091	Upadacitinib	ATP-binding cassette sub-family G member 2	transporter
DB15091	Upadacitinib	Solute carrier organic anion transporter family member 1B1	transporter
DB05679	Ustekinumab	Interleukin-12 subunit beta	target
DB05679	Ustekinumab	Interleukin-23	target

Drug	Drug Name	Phase	Status	Count
DB16650	Deucravacitinib	2	Completed	1
DB05679	Ustekinumab	2	Completed	1
DB08904	Certolizumab pegol	3	Completed	1
DB12917	Bimekizumab	4	Withdrawn	1
DB08895	Tofacitinib	Not Available	Recruiting	1