Postoperative Nausea and Vomiting

Also known as: Nausea and Vomiting, Postoperative / Postoperative Nausea and Vomiting (PONV) / Postoperative Nausea and Vomit / Postoperative Vomiting and Nausea / Post Operative Nausea and Vomiting (PONV) / Post-Operative Nausea and Vomiting / Post-Operative Nausea and Vomiting (PONV) / Post Operative Nausea and Vomiting / Ponv / Postoperative nausea and vomiting (disorder)

DrugDrug NameDrug Description
DB06288AmisulprideA dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults.
DB00673AprepitantA substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
DB00985DimenhydrinateA medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness.
DB00757DolasetronAn antinauseant and antiemetic used in chemotherapy and postoperatively.
DB01233MetoclopramideAn antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying.
DB00370MirtazapineA tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
DB00904OndansetronA serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.
DB00377PalonosetronA serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting.
DB00747ScopolamineA belladonna alkaloid with anticholinergic effects indicated for the treatment of nausea and vomiting associated with motion sickness and postoperative nausea and vomiting (PONV).
DrugDrug NameTargetType
DB06288AmisulprideDopamine D2 receptortarget
DB06288AmisulprideDopamine D3 receptortarget
DB06288Amisulpride5-hydroxytryptamine receptor 7target
DB06288Amisulpride5-hydroxytryptamine receptor 2Atarget
DB06288AmisulprideErythrocytecarrier
DB06288AmisulprideMultidrug and toxin extrusion protein 1transporter
DB06288AmisulprideMultidrug and toxin extrusion protein 2transporter
DB06288AmisulprideP-glycoprotein 1transporter
DB06288AmisulprideATP-binding cassette sub-family G member 2transporter
DB06288AmisulprideSolute carrier family 22 member 1transporter
DB06288AmisulprideMu-type opioid receptortarget
DB06288AmisulprideDelta-type opioid receptortarget
DB06288AmisulprideKappa-type opioid receptortarget
DB00673AprepitantNeurokinin 1 receptortarget
DB00673AprepitantCytochrome P450 3A4enzyme
DB00673AprepitantCytochrome P450 2C9enzyme
DB00673AprepitantCytochrome P450 2C19enzyme
DB00985DimenhydrinateHistamine H1 receptortarget
DB00757Dolasetron5-hydroxytryptamine receptor 3Atarget
DB00757DolasetronCytochrome P450 3A4enzyme
DB00757DolasetronCytochrome P450 2D6enzyme
DB00757DolasetronCytochrome P450 2C9enzyme
DB01233MetoclopramideMuscarinic acetylcholine receptor M1target
DB01233MetoclopramideDopamine D2 receptortarget
DB01233MetoclopramideCytochrome P450 2D6enzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 4target
DB01233Metoclopramide5-hydroxytryptamine receptor 3Atarget
DB01233MetoclopramideCytochrome P450 3A4enzyme
DB01233MetoclopramideCytochrome P450 1A2enzyme
DB01233MetoclopramideP-glycoprotein 1transporter
DB01233MetoclopramideAlpha-1-acid glycoprotein 1carrier
DB00370Mirtazapine5-hydroxytryptamine receptor 2Atarget
DB00370Mirtazapine5HT3 serotonin receptortarget
DB00370MirtazapineAlpha-2A adrenergic receptortarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Ctarget
DB00370MirtazapineKappa-type opioid receptortarget
DB00370MirtazapineHistamine H1 receptortarget
DB00370MirtazapineCytochrome P450 1A2enzyme
DB00370MirtazapineCytochrome P450 3A4enzyme
DB00370MirtazapineCytochrome P450 2D6enzyme
DB00370MirtazapineAlpha-1 adrenergic receptorstarget
DB00370MirtazapineSodium-dependent serotonin transportertransporter
DB00904Ondansetron5-hydroxytryptamine receptor 3Atarget
DB00904OndansetronCytochrome P450 3A4enzyme
DB00904OndansetronCytochrome P450 1A2enzyme
DB00904OndansetronCytochrome P450 2D6enzyme
DB00904OndansetronCytochrome P450 3A5enzyme
DB00904OndansetronCytochrome P450 3A7enzyme
DB00904Ondansetron5-hydroxytryptamine receptor 4target
DB00904Ondansetron5-hydroxytryptamine receptor 1Atarget
DB00904Ondansetron5-hydroxytryptamine receptor 1Btarget
DB00904OndansetronMu-type opioid receptortarget
DB00904OndansetronCytochrome P450 2C9enzyme
DB00904OndansetronCytochrome P450 2E1enzyme
DB00377Palonosetron5-hydroxytryptamine receptor 3Atarget
DB00377PalonosetronCytochrome P450 2D6enzyme
DB00377PalonosetronCytochrome P450 3A4enzyme
DB00377PalonosetronCytochrome P450 1A2enzyme
DB00747ScopolamineMuscarinic acetylcholine receptor M1target
DB00747ScopolamineSucrase-isomaltase, intestinaltarget
DB00747ScopolamineMuscarinic acetylcholine receptor M2target
DB00747ScopolamineMuscarinic acetylcholine receptor M3target
DB00747ScopolamineMuscarinic acetylcholine receptor M4target
DB00747ScopolamineMuscarinic acetylcholine receptor M5target
DB00747ScopolamineNeuronal acetylcholine receptor subunit alpha-4target
DB00747ScopolamineNeuronal acetylcholine receptor subunit beta-2target
DB00747ScopolamineCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount
DB09061Cannabidiol0Recruiting1
DB01234Dexamethasone0Recruiting1
DB00370Mirtazapine0Recruiting1
DB00673Aprepitant1Completed2
DB01234Dexamethasone1Completed1
DB00633Dexmedetomidine1Completed1
DB06717Fosaprepitant1Completed1
DB00683Midazolam1Completed1
DB00904Ondansetron1Completed3
DB11949Vestipitant1Completed1
DB00904Ondansetron1 / 2Completed1
DB00316Acetaminophen2Completed1
DB00673Aprepitant2Not Yet Recruiting1
DB00673Aprepitant2Unknown Status1
DB09020Bisacodyl2Completed1
DB06634Casopitant2Completed1
DB01234Dexamethasone2Completed4
DB01234Dexamethasone2Recruiting2
DB01234Dexamethasone2Terminated1
DB01234Dexamethasone2Unknown Status3
DB00633Dexmedetomidine2Recruiting1
DB09341Dextrose, unspecified form2Not Yet Recruiting1
DB00985Dimenhydrinate2Completed1
DB11114Eucalyptus oil2Completed1
DB00889Granisetron2Completed1
DB00889Granisetron2Unknown Status1
DB00486Nabilone2Completed1
DB00184Nicotine2Terminated1
DB00334Olanzapine2Completed1
DB00334Olanzapine2Recruiting1
DB00904Ondansetron2Completed6
DB00904Ondansetron2Recruiting2
DB00377Palonosetron2Completed1
DB10984Peppermint2Completed1
DB00860Prednisolone2Completed1
DB00230Pregabalin2Not Yet Recruiting1
DB00818Propofol2Recruiting1
DB09290Ramosetron2Completed1
DB09290Ramosetron2Unknown Status1
DB09291Rolapitant2Completed1
DB11949Vestipitant2Completed2
DB11195Xylitol2Completed1
DB06288Amisulpride2 / 3Not Yet Recruiting1
DB00673Aprepitant2 / 3Completed1
DB00181Baclofen2 / 3Recruiting1
DB01234Dexamethasone2 / 3Completed3
DB01234Dexamethasone2 / 3Not Yet Recruiting1
DB00470Dronabinol2 / 3Recruiting1
DB00996Gabapentin2 / 3Completed1
DB14009Medical Cannabis2 / 3Recruiting1
DB00334Olanzapine2 / 3Completed1
DB00316Acetaminophen3Terminated1
DB06288Amisulpride3Completed1
DB06288Amisulpride3Not Yet Recruiting1
DB00673Aprepitant3Completed2
DB00297Bupivacaine3Withdrawn1
DB06634Casopitant3Completed2
DB01234Dexamethasone3Completed3
DB01234Dexamethasone3Enrolling by Invitation1
DB01234Dexamethasone3Recruiting2
DB01234Dexamethasone3Unknown Status1
DB00633Dexmedetomidine3Recruiting1
DB00633Dexmedetomidine3Withdrawn1
DB00996Gabapentin3Completed1
DB00996Gabapentin3Recruiting1
DB00889Granisetron3Unknown Status1
DB01009Ketoprofen3Completed1
DB00683Midazolam3Unknown Status1
DB01183Naloxone3Completed1
DB01400Neostigmine3Completed1
DB00904Ondansetron3Completed5
DB00904Ondansetron3Enrolling by Invitation1
DB00904Ondansetron3Recruiting1
DB00497Oxycodone3Completed1
DB09140Oxygen3Not Yet Recruiting1
DB00377Palonosetron3Completed2
DB00377Palonosetron3Enrolling by Invitation1
DB00377Palonosetron3Unknown Status1
DB09290Ramosetron3Completed1
DB00296Ropivacaine3Terminated1
DB00296Ropivacaine3Withdrawn1
DB06206Sugammadex3Completed1
DB00316Acetaminophen4Completed3
DB00316Acetaminophen4Terminated1
DB00673Aprepitant4Active Not Recruiting1
DB00673Aprepitant4Completed9
DB00673Aprepitant4Recruiting1
DB00673Aprepitant4Terminated1
DB00673Aprepitant4Unknown Status1
DB13295Atracurium4Completed1
DB00572Atropine4Completed1
DB00207Azithromycin4Unknown Status1
DB09084Benzydamine4Completed1
DB00083Botulinum toxin type A4Completed1
DB00297Bupivacaine4Active Not Recruiting1
DB00297Bupivacaine4Completed1
DB00878Chlorhexidine4Completed1
DB01189Desflurane4Completed1
DB01234Dexamethasone4Completed21
DB01234Dexamethasone4Not Yet Recruiting1
DB01234Dexamethasone4Recruiting4
DB01234Dexamethasone4Terminated1
DB01234Dexamethasone4Unknown Status4
DB00633Dexmedetomidine4Completed2
DB00985Dimenhydrinate4Completed1
DB00450Droperidol4Completed1
DB00668Epinephrine4Completed1
DB00813Fentanyl4Completed2
DB06717Fosaprepitant4Unknown Status1
DB00996Gabapentin4Completed1
DB00986Glycopyrronium4Completed2
DB00986Glycopyrronium4Recruiting1
DB00889Granisetron4Completed2
DB00889Granisetron4Not Yet Recruiting1
DB00502Haloperidol4Completed2
DB00956Hydrocodone4Terminated1
DB00327Hydromorphone4Terminated1
DB01050Ibuprofen4Completed1
DB01221Ketamine4Completed4
DB01221Ketamine4Recruiting1
DB01002Levobupivacaine4Completed1
DB00281Lidocaine4Completed5
DB00281Lidocaine4Unknown Status1
DB00281Lidocaine4Withdrawn1
DB00653Magnesium sulfate4Recruiting1
DB00333Methadone4Completed1
DB00959Methylprednisolone4Completed2
DB01233Metoclopramide4Completed2
DB00683Midazolam4Completed1
DB00370Mirtazapine4Completed1
DB00295Morphine4Completed3
DB01400Neostigmine4Terminated1
DB14881Oliceridine4Completed1
DB00904Ondansetron4Completed17
DB00904Ondansetron4Not Yet Recruiting1
DB00904Ondansetron4Recruiting2
DB00904Ondansetron4Unknown Status3
DB00497Oxycodone4Terminated1
DB00377Palonosetron4Completed8
DB00377Palonosetron4Recruiting1
DB00377Palonosetron4Unknown Status2
DB16287Penequinine, Penehyclidine4Completed1
DB12492Piritramide4Completed1
DB00230Pregabalin4Recruiting1
DB00433Prochlorperazine4Completed1
DB01069Promethazine4Completed2
DB00818Propofol4Completed5
DB09290Ramosetron4Completed4
DB09290Ramosetron4Unknown Status3
DB00899Remifentanil4Completed1
DB12404Remimazolam4Completed1
DB00296Ropivacaine4Completed2
DB00296Ropivacaine4Recruiting1
DB00747Scopolamine4Completed1
DB01236Sevoflurane4Completed3
DB09153Sodium chloride4Completed2
DB09153Sodium chloride4Recruiting2
DB09153Sodium chloride4Withdrawn1
DB09449Sodium phosphate, monobasic4Recruiting1
DB00708Sufentanil4Completed2
DB06206Sugammadex4Completed1
DB06206Sugammadex4Terminated1
DB00599Thiopental4Completed1
DB00193Tramadol4Completed1
DB11699Tropisetron4Completed1
DB00316AcetaminophenNot AvailableCompleted3
DB00316AcetaminophenNot AvailableNot Yet Recruiting1
DB00316AcetaminophenNot AvailableUnknown Status1
DB00802AlfentanilNot AvailableCompleted1
DB06288AmisulprideNot AvailableWithdrawn1
DB00673AprepitantNot AvailableCompleted3
DB00673AprepitantNot AvailableEnrolling by Invitation1
DB00673AprepitantNot AvailableWithdrawn3
DB13295AtracuriumNot AvailableCompleted1
DB00297BupivacaineNot AvailableCompleted1
DB00297BupivacaineNot AvailableUnknown Status1
DB00201CaffeineNot AvailableCompleted1
DB01112CefuroximeNot AvailableCompleted1
DB01189DesfluraneNot AvailableCompleted1
DB01234DexamethasoneNot AvailableActive Not Recruiting1
DB01234DexamethasoneNot AvailableCompleted12
DB01234DexamethasoneNot AvailableNot Yet Recruiting1
DB01234DexamethasoneNot AvailableUnknown Status1
DB01234DexamethasoneNot AvailableWithdrawn1
DB00633DexmedetomidineNot AvailableCompleted7
DB00633DexmedetomidineNot AvailableNot Yet Recruiting1
DB00633DexmedetomidineNot AvailableRecruiting1
DB00633DexmedetomidineNot AvailableUnknown Status1
DB01075DiphenhydramineNot AvailableWithdrawn1
DB00757DolasetronNot AvailableCompleted1
DB00470DronabinolNot AvailableCompleted1
DB00450DroperidolNot AvailableCompleted1
DB00187EsmololNot AvailableCompleted1
DB00927FamotidineNot AvailableActive Not Recruiting2
DB00813FentanylNot AvailableCompleted3
DB00813FentanylNot AvailableRecruiting1
DB06717FosaprepitantNot AvailableEnrolling by Invitation1
DB06717FosaprepitantNot AvailableNot Yet Recruiting1
DB00996GabapentinNot AvailableCompleted1
DB00996GabapentinNot AvailableUnknown Status2
DB00889GranisetronNot AvailableCompleted2
DB00889GranisetronNot AvailableRecruiting1
DB01018GuanfacineNot AvailableCompleted1
DB00502HaloperidolNot AvailableCompleted1
DB00956HydrocodoneNot AvailableCompleted1
DB00327HydromorphoneNot AvailableCompleted2
DB00753IsofluraneNot AvailableCompleted1
DB01221KetamineNot AvailableCompleted1
DB00465KetorolacNot AvailableCompleted1
DB00465KetorolacNot AvailableNot Yet Recruiting1
DB00281LidocaineNot AvailableCompleted4
DB00281LidocaineNot AvailableUnknown Status1
DB00186LorazepamNot AvailableWithdrawn1
DB00737MeclizineNot AvailableCompleted1
DB01065MelatoninNot AvailableCompleted1
DB00454MeperidineNot AvailableCompleted1
DB04817MetamizoleNot AvailableCompleted2
DB00333MethadoneNot AvailableCompleted1
DB01233MetoclopramideNot AvailableCompleted1
DB01233MetoclopramideNot AvailableWithdrawn1
DB00683MidazolamNot AvailableCompleted4
DB00295MorphineNot AvailableCompleted3
DB00295MorphineNot AvailableNot Yet Recruiting1
DB00844NalbuphineNot AvailableUnknown Status1
DB01183NaloxoneNot AvailableCompleted2
DB00184NicotineNot AvailableWithdrawn1
DB00904OndansetronNot AvailableActive Not Recruiting1
DB00904OndansetronNot AvailableCompleted8
DB00904OndansetronNot AvailableNot Yet Recruiting1
DB00904OndansetronNot AvailableRecruiting1
DB00904OndansetronNot AvailableUnknown Status1
DB00904OndansetronNot AvailableWithdrawn3
DB00497OxycodoneNot AvailableCompleted1
DB01192OxymorphoneNot AvailableCompleted1
DB00377PalonosetronNot AvailableCompleted5
DB00377PalonosetronNot AvailableUnknown Status1
DB16287Penequinine, PenehyclidineNot AvailableCompleted2
DB00981PhysostigmineNot AvailableUnknown Status1
DB00230PregabalinNot AvailableUnknown Status1
DB01069PromethazineNot AvailableActive Not Recruiting1
DB01069PromethazineNot AvailableCompleted1
DB09288PropacetamolNot AvailableCompleted2
DB00807ProparacaineNot AvailableCompleted1
DB00818PropofolNot AvailableCompleted3
DB00818PropofolNot AvailableRecruiting1
DB09290RamosetronNot AvailableCompleted6
DB09290RamosetronNot AvailableUnknown Status1
DB00863RanitidineNot AvailableCompleted1
DB00899RemifentanilNot AvailableCompleted2
DB12404RemimazolamNot AvailableRecruiting1
DB00296RopivacaineNot AvailableNot Yet Recruiting1
DB00296RopivacaineNot AvailableUnknown Status1
DB00936Salicylic acidNot AvailableCompleted1
DB00747ScopolamineNot AvailableCompleted1
DB01236SevofluraneNot AvailableCompleted3
DB09153Sodium chlorideNot AvailableCompleted1
DB09153Sodium chlorideNot AvailableNot Yet Recruiting1
DB00708SufentanilNot AvailableCompleted1
DB00193TramadolNot AvailableCompleted1
DB11699TropisetronNot AvailableCompleted2