Heterotopic ossification

Also known as: Ossification, Heterotopic / Heterotopic Ossification / Heterotopic Ossification (HO) / Heterotopic ossification (finding) / Ectopic ossification / Extraskeletal ossification / Osseous metaplasia (morphologic abnormality, calcified structure) (morphologic abnormality) / Osteosis

Drug	Drug Name	Drug Description
DB01077	Etidronic acid	A bisphosphonate drug that prevents osteoclastic bone resorption; used for the prevention and treatment of osteoporosis.
DB05467	Palovarotene	A selective agonist of retinoic acid receptor gamma (RARγ) used to reduce heterotopic ossification in patients with Fibrodysplasia Ossificans Progressiva (FOP).

Drug	Drug Name	Target	Type
DB01077	Etidronic acid	Hydroxylapatite	target
DB01077	Etidronic acid	Receptor-type tyrosine-protein phosphatase S	target
DB01077	Etidronic acid	V-type proton ATPase catalytic subunit A	target
DB01077	Etidronic acid	ADP/ATP translocase 1	target
DB01077	Etidronic acid	ADP/ATP translocase 2	target
DB01077	Etidronic acid	ADP/ATP translocase 3	target
DB05467	Palovarotene	Retinoic acid receptor gamma	target
DB05467	Palovarotene	Cytochrome P450 3A4	enzyme
DB05467	Palovarotene	Cytochrome P450 2C8	enzyme
DB05467	Palovarotene	Cytochrome P450 2C19	enzyme
DB05467	Palovarotene	ATP-binding cassette sub-family G member 2	transporter
DB05467	Palovarotene	Solute carrier organic anion transporter family member 1B1	transporter
DB05467	Palovarotene	Solute carrier organic anion transporter family member 1B3	transporter
DB05467	Palovarotene	Solute carrier family 22 member 1	transporter
DB05467	Palovarotene	Bile salt export pump	transporter
DB05467	Palovarotene	Cytochrome P450 2B6	enzyme

Drug	Drug Name	Phase	Status	Count
DB00788	Naproxen	0	Completed	1
DB16379	Garetosmab	3	Withdrawn	1
DB01628	Etoricoxib	4	Completed	1
DB00788	Naproxen	4	Withdrawn	1
DB00482	Celecoxib	Not Available	Unknown Status	1
DB00586	Diclofenac	Not Available	Completed	1
DB00282	Pamidronic acid	Not Available	Withdrawn	1
DB00302	Tranexamic acid	Not Available	Completed	1