Association Browse

Displaying targets 1 - 25 of 4172 in total

Name	UniProt ID Gene Name	Species Category Species	Specific function
Prothrombin	P00734 F2	human Homo sapiens	Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C
Gonadotropin-releasing hormone receptor	P30968 GNRHR	human Homo sapiens	Receptor for gonadotropin releasing hormone (GnRH) that mediate the action of GnRH to stimulate the secretion of the gonadotropic hormones (LH and FSH). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act a an inhibitor of GnRH-R signaling
Prostaglandin G/H synthase 2	P35354 PTGS2	human Homo sapiens	May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity
Interferon-alpha/beta receptor beta chain	P48551 IFNAR2	human Homo sapiens	Receptor for interferons alpha and beta. Isoform 1 and isoform 3 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity
Interleukin-2 receptor subunit beta	P14784 IL2RB	human Homo sapiens	Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2
Interleukin-2 receptor alpha chain	P01589 IL2RA	human Homo sapiens	Receptor for interleukin-2
Interferon-alpha/beta receptor alpha chain	P17181 IFNAR1	human Homo sapiens	Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves
Tumor necrosis factor	P01375 TNF	human Homo sapiens	Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation
High affinity immunoglobulin gamma Fc receptor I	P12314 FCGR1A	human Homo sapiens	Binds to the Fc region of immunoglobulins gamma. High affinity receptor
Epidermal growth factor receptor	P00533 EGFR	human Homo sapiens	Isoform 2/truncated isoform may act as an antagonist
DNA			DNA is the molecule of heredity, as it is responsible for the genetic propagation of most inherited traits. It is a polynucleic acid that carries genetic information on cell growth, division, and function. DNA consists of two long strands of nucleotides twisted into a double helix and held together by hydrogen bonds. The sequence of nucleotides determines hereditary characteristics. Each strand serves as the template for subsequent DNA replication and as a template for mRNA production, leading to protein synthesis via ribosomes.
Low affinity immunoglobulin gamma Fc region receptor III-B	O75015 FCGR3B	human Homo sapiens	Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils
Tumor necrosis factor receptor superfamily member 1B	P20333 TNFRSF1B	human Homo sapiens	Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity
Myeloperoxidase	P05164 MPO	human Homo sapiens	Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity
Lymphotoxin-alpha	P01374 LTA	human Homo sapiens	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo
Complement C1s subcomponent	P09871 C1S	human Homo sapiens	C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4
Complement C1r subcomponent	P00736 C1R	human Homo sapiens	C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system
Complement C1q subcomponent subunit A	P02745 C1QA	human Homo sapiens	C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes
Complement C1q subcomponent subunit B	P02746 C1QB	human Homo sapiens	C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes
Complement C1q subcomponent subunit C	P02747 C1QC	human Homo sapiens	C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes
Low affinity immunoglobulin gamma Fc region receptor III-A	P08637 FCGR3A	human Homo sapiens	Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis
Low affinity immunoglobulin gamma Fc region receptor II-a	P12318 FCGR2A	human Homo sapiens	Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens
Low affinity immunoglobulin gamma Fc region receptor II-b	P31994 FCGR2B	human Homo sapiens	Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis
Low affinity immunoglobulin gamma Fc region receptor II-c	P31995 FCGR2C	human Homo sapiens	Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells
Cytokine receptor common gamma chain	P31785 IL2RG	human Homo sapiens	Common subunit for the receptors for a variety of interleukins

Displaying targets 1 - 25 of 4172 in total