Muscarinic acetylcholine receptor M1

103

Name

Muscarinic acetylcholine receptor M1

Synonyms

Not Available

Gene Name

CHRM1

Protein Sequence

>Muscarinic acetylcholine receptor M1
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

Number of Residues

460

Molecular Weight

51421

Theoretical pI

9.67

GO Classification

Component
cell
intrinsic to membrane
integral to membrane
membrane
Function
amine receptor activity
muscarinic acetylcholine receptor activity
signal transducer activity
receptor activity
transmembrane receptor activity
G-protein coupled receptor activity
rhodopsin-like receptor activity
Process
cell communication
signal transduction
cell surface receptor linked signal transduction
G-protein coupled receptor protein signaling pathway
cellular process

General Function

Involved in rhodopsin-like receptor activity

Specific Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Pathways

Not Available

Reactions

Not Available

Pfam Domain Function

7tm_1 (PF00001 )

Signals

None

Transmembrane Regions

25-47 62-82 100-121 142-164 187-209 367-387 402-421

Essentiality

Non-Essential

GenBank Protein ID

34451

UniProtKB ID

P11229

UniProtKB Entry Name

ACM1_HUMAN Link_out

PDB ID

Not Available

Cellular Location

Membrane; multi-pass membrane protein

Gene Sequence

>1383 bp
ATGAACACTTCAGCCCCACCTGCTGTCAGCCCCAACATCACCGTCCTGGCACCAGGAAAG
GGTCCCTGGCAAGTGGCCTTCATTGGGATCACCACGGGCCTCCTGTCGCTAGCCACAGTG
ACAGGCAACCTGCTGGTACTCATCTCTTTCAAGGTCAACACGGAGCTCAAGACAGTCAAT
AACTACTTCCTGCTGAGCCTGGCCTGTGCTGACCTCATCATCGGTACCTTCTCCATGAAC
CTCTATACCACGTACCTGCTCATGGGCCACTGGGCTCTGGGCACGCTGGCTTGTGACCTC
TGGCTGGCCCTGGACTATGTGGCCAGCAATGCCTCCGTCATGAATCTGCTGCTCATCAGC
TTTGACCGCTACTTCTCCGTGACTCGGCCCCTGAGCTACCGTGCCAAGCGCACACCCCGC
CGGGCAGCTCTGATGATCGGCCTGGCCTGGCTGGTTTCCTTTGTGCTCTGGGCCCCAGCC
ATCCTCTTCTGGCAGTACCTGGTAGGGGAGCGGACAGTGCTAGCTGGGCAGTGCTACATC
CAGTTCCTCTCCCAGCCCATCATCACCTTTGGCACAGCCATGGCTGCCTTCTACCTCCCT
GTCACAGTCATGTGCACGCTCTACTGGCGCATCTACCGGGAGACAGAGAACCGAGCACGG
GAGCTGGCAGCCCTTCAGGGCTCCGAGACGCCAGGCAAAGGGGGTGGCAGCAGCAGCAGC
TCAGAGAGGTCTCAGCCAGGGGCTGAGGGCTCACCAGAGACTCCTCCAGGCCGCTGCTGT
CGCTGCTGCCGGGCCCCCAGGCTGCTGCAGGCCTACAGCTGGAAGGAAGAAGAGGAAGAG
GACGAAGGCTCCATGGAGTCCCTCACATCCTCAGAGGGAGAGGAGCCTGGCTCCGAAGTG
GTGATCAAGATGCCAATGGTGGACCCCGAGGCACAGGCCCCCACCAAGCAGCCCCCACGG
AGCTCCCCAAATACAGTCAAGAGGCCGACTAAGAAAGGGCGTGATCGAGCTGGCAAGGGC
CAGAAGCCCCGTGGAAAGGAGCAGCTGGCCAAGCGGAAGACCTTCTCGCTGGTCAAGGAG
AAGAAGGCGGCTCGGACCCTGAGTGCCATCCTCCTGGCCTTCATCCTCACCTGGACACCG
TACAACATCATGGTGCTGGTGTCCACCTTCTGCAAGGACTGTGTTCCCGAGACCCTGTGG
GAGCTGGGCTACTGGCTGTGCTACGTCAACAGCACCATCAACCCCATGTGCTACGCACTC
TGCAACAAAGCCTTCCGGGACACCTTTCGCCTGCTGCTGCTTTGCCGCTGGGACAAGAGA
CGCTGGCGCAAGATCCCCAAGCGCCCTGGCTCCGTGCACCGCACTCCCTCCCGCCAATGC
TGA

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

HPRD ID

00338

IUPHAR ID

Guide to Pharmacology ID

Chromosome Location

Not Available

Locus

11q13

SNPs

CHRM1

General References

Allard WJ, Sigal IS, Dixon RA: Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor. Nucleic Acids Res. 1987 Dec 23;15(24):10604. Pubmed
Chapman CG, Browne MJ: Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification. Nucleic Acids Res. 1990 Apr 25;18(8):2191. Pubmed
Peralta EG, Ashkenazi A, Winslow JW, Smith DH, Ramachandran J, Capon DJ: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J. 1987 Dec 20;6(13):3923-9. Pubmed
Arden JR, Nagata O, Shockley MS, Philip M, Lameh J, Sadee W: Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor. Biochem Biophys Res Commun. 1992 Nov 16;188(3):1111-5. Pubmed

Drugs

#	DrugBank ID	Drug Name	Drug Type	Drug Groups
1	DB00321	Amitriptyline	small molecule	approved
2	DB00543	Amoxapine	small molecule	approved
3	DB00517	Anisotropine Methylbromide	small molecule	approved
4	DB04365	Arecoline	small molecule	experimental
5	DB01238	Aripiprazole	small molecule	approved, investigational
6	DB00572	Atropine	small molecule	approved
7	DB00245	Benzatropine	small molecule	approved
8	DB00767	Benzquinamide	small molecule	approved
9	DB00810	Biperiden	small molecule	approved
10	DB00835	Brompheniramine	small molecule	approved
11	DB00354	Buclizine	small molecule	approved
12	DB00411	Carbachol	small molecule	approved
13	DB00185	Cevimeline	small molecule	approved
14	DB01239	Chlorprothixene	small molecule	approved
15	DB00771	Clidinium	small molecule	approved
16	DB00363	Clozapine	small molecule	approved
17	DB00907	Cocaine	small molecule	illicit, approved
18	DB00785	Cryptenamine	small molecule	approved
19	DB00979	Cyclopentolate	small molecule	approved
20	DB00942	Cycrimine	small molecule	approved
21	DB00434	Cyproheptadine	small molecule	approved
22	DB00496	Darifenacin	small molecule	approved, investigational
23	DB01151	Desipramine	small molecule	approved
24	DB00804	Dicyclomine	small molecule	approved
25	DB01231	Diphenidol	small molecule	approved
26	DB00280	Disopyramide	small molecule	approved
27	DB01142	Doxepin	small molecule	approved
28	DB00366	Doxylamine	small molecule	approved
29	DB01175	Escitalopram	small molecule	approved, investigational
30	DB00392	Ethopropazine	small molecule	approved
31	DB06702	Fesoterodine	small molecule	approved
32	DB01148	Flavoxate	small molecule	approved
33	DB00875	Flupenthixol	small molecule	approved
34	DB00986	Glycopyrrolate	small molecule	approved, investigational
35	DB00725	Homatropine Methylbromide	small molecule	approved
36	DB00424	Hyoscyamine	small molecule	approved
37	DB00458	Imipramine	small molecule	approved
38	DB00332	Ipratropium bromide	small molecule	approved
39	DB00934	Maprotiline	small molecule	approved
40	DB04843	Mepenzolate	small molecule	approved
41	DB00940	Methantheline	small molecule	approved
42	DB01403	Methotrimeprazine	small molecule	approved
43	DB00462	Methylscopolamine	small molecule	approved
44	DB00340	Metixene	small molecule	approved
45	DB01233	Metoclopramide	small molecule	approved, investigational
46	DB00805	Minaprine	small molecule	approved
47	DB01618	Molindone	small molecule	approved
48	DB00622	Nicardipine	small molecule	approved
49	DB00540	Nortriptyline	small molecule	approved
50	DB00334	Olanzapine	small molecule	approved, investigational
51	DB01062	Oxybutynin	small molecule	approved, investigational
52	DB00383	Oxyphencyclimine	small molecule	approved
53	DB00219	Oxyphenonium	small molecule	approved
54	DB00715	Paroxetine	small molecule	approved, investigational
55	DB01085	Pilocarpine	small molecule	approved
56	DB00670	Pirenzepine	small molecule	approved
57	DB00387	Procyclidine	small molecule	approved
58	DB00420	Promazine	small molecule	approved
59	DB01069	Promethazine	small molecule	approved
60	DB00782	Propantheline	small molecule	approved
61	DB00777	Propiomazine	small molecule	approved
62	DB01224	Quetiapine	small molecule	approved
63	DB00747	Scopolamine	small molecule	approved
64	DB01591	Solifenacin	small molecule	approved
65	DB00202	Succinylcholine	small molecule	approved
66	DB01409	Tiotropium	small molecule	approved
67	DB01036	Tolterodine	small molecule	approved, investigational
68	DB00505	Tridihexethyl	small molecule	approved
69	DB00508	Triflupromazine	small molecule	approved
70	DB00376	Trihexyphenidyl	small molecule	approved
71	DB00809	Tropicamide	small molecule	approved
72	DB00209	Trospium	small molecule	approved
73	DB00246	Ziprasidone	small molecule	approved