Multidrug resistance protein 1

1588

Name

Multidrug resistance protein 1

Synonyms

EC 3.6.3.44
ATP-binding cassette sub-family B member 1
P-glycoprotein 1
CD243 antigen

Gene Name

ABCB1

Protein Sequence

>Multidrug resistance protein 1
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII
HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG
IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS
KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT
DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG
AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG
AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG
QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF
ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA
IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG
FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS
SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII
NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA
GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI
ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEA
IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG
AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS
YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV
SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD
EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL
LAQKGIYFSMVSVQAGTKRQ

Number of Residues

1280

Molecular Weight

141464

Theoretical pI

9.44

GO Classification

Component
cell
intrinsic to membrane
integral to membrane
membrane
Function
binding
ATP binding
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleotide binding
pyrophosphatase activity
catalytic activity
nucleoside-triphosphatase activity
hydrolase activity
ATPase activity
purine nucleotide binding
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
adenyl nucleotide binding
ATPase activity, coupled to transmembrane movement of substances
Process
physiological process
cellular physiological process
transport

General Function

Defense mechanisms and drug export

Specific Function

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells

Pathways

Name	SMPDB Link	KEGG Link
Paclitaxel Pathway	SMP00434
Docetaxel Pathway	SMP00435
Vinblastine Pathway	SMP00436
Vincristine Pathway	SMP00437
Vindesine Pathway	SMP00438
Vinorelbine Pathway	SMP00439

Reactions

ATP + H2O + xenobioticin = ADP + phosphate + xenobioticout

Pfam Domain Function

ABC_tran (PF00005 )
ABC_membrane (PF00664 )

Signals

None

Transmembrane Regions

52-72 120-140 189-209 216-236 297-317 326-346 711-731 757-777 833-853 854-874 937-957 974-994

Essentiality

Non-Essential

GenBank Protein ID

307180

UniProtKB ID

P08183

UniProtKB Entry Name

MDR1_HUMAN Link_out

PDB ID

Not Available

Cellular Location

Membrane; multi-pass membrane protein

Gene Sequence

>3843 bp
ATGGATCTTGAAGGGGACCGCAATGGAGGAGCAAAGAAGAAGAACTTTTTTAAACTGAAC
AATAAAAGTGAAAAAGATAAGAAGGAAAAGAAACCAACTGTCAGTGTATTTTCAATGTTT
CGCTATTCAAATTGGCTTGACAAGTTGTATATGGTGGTGGGAACTTTGGCTGCCATCATC
CATGGGGCTGGACTTCCTCTCATGATGCTGGTGTTTGGAGAAATGACAGATATCTTTGCA
AATGCAGGAAATTTAGAAGATCTGATGTCAAACATCACTAATAGAAGTGATATCAATGAT
ACAGGGTTCTTCATGAATCTGGAGGAAGACATGACCAGGTATGCCTATTATTACAGTGGA
ATTGGTGCTGGGGTGCTGGTTGCTGCTTACATTCAGGTTTCATTTTGGTGCCTGGCAGCT
GGAAGACAAATACACAAAATTAGAAAACAGTTTTTTCATGCTATAATGCGACAGGAGATA
GGCTGGTTTGATGTGCACGATGTTGGGGAGCTTAACACCCGACTTACAGATGATGTCTCT
AAGATTAATGAAGTTATTGGTGACAAAATTGGAATGTTCTTTCAGTCAATGGCAACATTT
TTCACTGGGTTTATAGTAGGATTTACACGTGGTTGGAAGCTAACCCTTGTGATTTTGGCC
ATCAGTCCTGTTCTTGGACTGTCAGCTGCTGTCTGGGCAAAGATACTATCTTCATTTACT
GATAAAGAACTCTTAGCGTATGCAAAAGCTGGAGCAGTAGCTGAAGAGGTCTTGGCAGCA
ATTAGAACTGTGATTGCATTTGGAGGACAAAAGAAAGAACTTGAAAGGTACAACAAAAAT
TTAGAAGAAGCTAAAAGAATTGGGATAAAGAAAGCTATTACAGCCAATATTTCTATAGGT
GCTGCTTTCCTGCTGATCTATGCATCTTATGCTCTGGCCTTCTGGTATGGGACCACCTTG
GTCCTCTCAGGGGAATATTCTATTGGACAAGTACTCACTGTATTCTTTTCTGTATTAATT
GGGGCTTTTAGTGTTGGACAGGCATCTCCAAGCATTGAAGCATTTGCAAATGCAAGAGGA
GCAGCTTATGAAATCTTCAAGATAATTGATAATAAGCCAAGTATTGACAGCTATTCGAAG
AGTGGGCACAAACCAGATAATATTAAGGGAAATTTGGAATTCAGAAATGTTCACTTCAGT
TACCCATCTCGAAAAGAAGTTAAGATCTTGAAGGGCCTGAACCTGAAGGTGCAGAGTGGG
CAGACGGTGGCCCTGGTTGGAAACAGTGGCTGTGGGAAGAGCACAACAGTCCAGCTGATG
CAGAGGCTCTATGACCCCACAGAGGGGATGGTCAGTGTTGATGGACAGGATATTAGGACC
ATAAATGTAAGGTTTCTACGGGAAATCATTGGTGTGGTGAGTCAGGAACCTGTATTGTTT
GCCACCACGATAGCTGAAAACATTCGCTATGGCCGTGAAAATGTCACCATGGATGAGATT
GAGAAAGCTGTCAAGGAAGCCAATGCCTATGACTTTATCATGAAACTGCCTCATAAATTT
GACACCCTGGTTGGAGAGAGAGGGGCCCAGTTGAGTGGTGGGCAGAAGCAGAGGATCGCC
ATTGCACGTGCCCTGGTTCGCAACCCCAAGATCCTCCTGCTGGATGAGGCCACGTCAGCC
TTGGACACAGAAAGCGAAGCAGTGGTTCAGGTGGCTCTGGATAAGGCCAGAAAAGGTCGG
ACCACCATTGTGATAGCTCATCGTTTGTCTACAGTTCGTAATGCTGACGTCATCGCTGGT
TTCGATGATGGAGTCATTGTGGAGAAAGGAAATCATGATGAACTCATGAAAGAGAAAGGC
ATTTACTTCAAACTTGTCACAATGCAGACAGCAGGAAATGAAGTTGAATTAGAAAATGCA
GCTGATGAATCCAAAAGTGAAATTGATGCCTTGGAAATGTCTTCAAATGATTCAAGATCC
AGTCTAATAAGAAAAAGATCAACTCGTAGGAGTGTCCGTGGATCACAAGCCCAAGACAGA
AAGCTTAGTACCAAAGAGGCTCTGGATGAAAGTATACCTCCAGTTTCCTTTTGGAGGATT
ATGAAGCTAAATTTAACTGAATGGCCTTATTTTGTTGTTGGTGTATTTTGTGCCATTATA
AATGGAGGCCTGCAACCAGCATTTGCAATAATATTTTCAAAGATTATAGGGGTTTTTACA
AGAATTGATGATCCTGAAACAAAACGACAGAATAGTAACTTGTTTTCACTATTGTTTCTA
GCCCTTGGAATTATTTCTTTTATTACATTTTTCCTTCAGGGTTTCACATTTGGCAAAGCT
GGAGAGATCCTCACCAAGCGGCTCCGATACATGGTTTTCCGATCCATGCTCAGACAGGAT
GTGAGTTGGTTTGATGACCCTAAAAACACCACTGGAGCATTGACTACCAGGCTCGCCAAT
GATGCTGCTCAAGTTAAAGGGGCTATAGGTTCCAGGCTTGCTGTAATTACCCAGAATATA
GCAAATCTTGGGACAGGAATAATTATATCCTTCATCTATGGTTGGCAACTAACACTGTTA
CTCTTAGCAATTGTACCCATCATTGCAATAGCAGGAGTTGTTGAAATGAAAATGTTGTCT
GGACAAGCACTGAAAGATAAGAAAGAACTAGAAGGTGCTGGGAAGATCGCTACTGAAGCA
ATAGAAAACTTCCGAACCGTTGTTTCTTTGACTCAGGAGCAGAAGTTTGAACATATGTAT
GCTCAGAGTTTGCAGGTACCATACAGAAACTCTTTGAGGAAAGCACACATCTTTGGAATT
ACATTTTCCTTCACCCAGGCAATGATGTATTTTTCCTATGCTGGATGTTTCCGGTTTGGA
GCCTACTTGGTGGCACATAAACTCATGAGCTTTGAGGATGTTCTGTTAGTATTTTCAGCT
GTTGTCTTTGGTGCCATGGCCGTGGGGCAAGTCAGTTCATTTGCTCCTGACTATGCCAAA
GCCAAAATATCAGCAGCCCACATCATCATGATCATTGAAAAAACCCCTTTGATTGACAGC
TACAGCACGGAAGGCCTAATGCCGAACACATTGGAAGGAAATGTCACATTTGGTGAAGTT
GTATTCAACTATCCCACCCGACCGGACATCCCAGTGCTTCAGGGACTGAGCCTGGAGGTG
AAGAAGGGCCAGACGCTGGCTCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACAGTGGTC
CAGCTCCTGGAGCGGTTCTACGACCCCTTGGCAGGGAAAGTGCTGCTTGATGGCAAAGAA
ATAAAGCGACTGAATGTTCAGTGGCTCCGAGCACACCTGGGCATCGTGTCCCAGGAGCCC
ATCCTGTTTGACTGCAGCATTGCTGAGAACATTGCCTATGGAGACAACAGCCGGGTGGTG
TCACAGGAAGAGATCGTGAGGGCAGCAAAGGAGGCCAACATACATGCCTTCATCGAGTCA
CTGCCTAATAAATATAGCACTAAAGTAGGAGACAAAGGAACTCAGCTCTCTGGTGGCCAG
AAACAACGCATTGCCATAGCTCGTGCCCTTGTTAGACAGCCTCATATTTTGCTTTTGGAT
GAAGCCACGTCAGCTCTGGATACAGAAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAAA
GCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCA
GACTTAATAGTGGTGTTTCAGAATGGCAGAGTCAAGGAGCATGGCACGCATCAGCAGCTG
CTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGAACAAAGCGCCAG
TGA

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

HPRD ID

01370

IUPHAR ID

Not Available

Guide to Pharmacology ID

Not Available

Chromosome Location

Not Available

Locus

7q21.1

SNPs

ABCB1

General References

Chen CJ, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB: Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell. 1986 Nov 7;47(3):381-9. Pubmed
Chen CJ, Clark D, Ueda K, Pastan I, Gottesman MM, Roninson IB: Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem. 1990 Jan 5;265(1):506-14. Pubmed
Chen G, Duran GE, Steger KA, Lacayo NJ, Jaffrezou JP, Dumontet C, Sikic BI: Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins. J Biol Chem. 1997 Feb 28;272(9):5974-82. Pubmed
Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O’Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK: The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-64. Pubmed
Gekeler V, Weger S, Probst H: mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles. Biochem Biophys Res Commun. 1990 Jun 15;169(2):796-802. Pubmed
Kioka N, Tsubota J, Kakehi Y, Komano T, Gottesman MM, Pastan I, Ueda K: P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance. Biochem Biophys Res Commun. 1989 Jul 14;162(1):224-31. Pubmed
Kerb R, Hoffmeyer S, Brinkmann U: ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2. Pharmacogenomics. 2001 Feb;2(1):51-64. Pubmed
Choi KH, Chen CJ, Kriegler M, Roninson IB: An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene. Cell. 1988 May 20;53(4):519-29. Pubmed
Mickley LA, Lee JS, Weng Z, Zhan Z, Alvarez M, Wilson W, Bates SE, Fojo T: Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors. Blood. 1998 Mar 1;91(5):1749-56. Pubmed
Decleves X, Chevillard S, Charpentier C, Vielh P, Laplanche JL: A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein. Hum Mutat. 2000 May;15(5):486. Pubmed
Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmoller J, Johne A, Cascorbi I, Gerloff T, Roots I, Eichelbaum M, Brinkmann U: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3473-8. Pubmed
Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M, Schaeffeler E, Eichelbaum M, Brinkmann U, Roots I: Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther. 2001 Mar;69(3):169-74. Pubmed
Saito S, Iida A, Sekine A, Miura Y, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y: Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. J Hum Genet. 2002;47(1):38-50. Pubmed

Drugs

#	DrugBank ID	Drug Name	Drug Type	Drug Groups
1	DB01193	Acebutolol	small molecule	approved
2	DB00316	Acetaminophen	small molecule	approved
3	DB00945	Acetylsalicylic acid	small molecule	approved
4	DB00171	Adenosine triphosphate	small molecule	approved, nutraceutical
5	DB00518	Albendazole	small molecule	approved
6	DB04630	Aldosterone	small molecule	experimental
7	DB00802	Alfentanil	small molecule	illicit, approved
8	DB00523	Alitretinoin	small molecule	approved, investigational
9	DB00915	Amantadine	small molecule	approved
10	DB00345	Aminohippurate	small molecule	approved
11	DB01118	Amiodarone	small molecule	approved, investigational
12	DB00321	Amitriptyline	small molecule	approved
13	DB00381	Amlodipine	small molecule	approved
14	DB00701	Amprenavir	small molecule	approved
15	DB00276	Amsacrine	small molecule	approved
16	DB01169	Arsenic trioxide	small molecule	approved, investigational
17	DB00637	Astemizole	small molecule	approved, withdrawn
18	DB01072	Atazanavir	small molecule	approved, investigational
19	DB00335	Atenolol	small molecule	approved
20	DB01076	Atorvastatin	small molecule	approved
21	DB00972	Azelastine	small molecule	approved
22	DB00207	Azithromycin	small molecule	approved
23	DB01086	Benzocaine	small molecule	approved
24	DB01244	Bepridil	small molecule	approved
25	DB00443	Betamethasone	small molecule	approved
26	DB00810	Biperiden	small molecule	approved
27	DB08873	Boceprevir	small molecule	approved
28	DB08870	BRENTUXIMAB VEDOTIN	small molecule	approved
29	DB01200	Bromocriptine	small molecule	approved, investigational
30	DB00921	Buprenorphine	small molecule	illicit, approved, investigational
31	DB00490	Buspirone	small molecule	approved, investigational
32	DB06772	Cabazitaxel	small molecule	approved
33	DB00201	Caffeine	small molecule	approved
34	DB04690	Camptothecin	small molecule	experimental
35	DB00796	Candesartan	small molecule	approved
36	DB01197	Captopril	small molecule	approved
37	DB00564	Carbamazepine	small molecule	approved, investigational
38	DB01136	Carvedilol	small molecule	approved, investigational
39	DB00520	Caspofungin	small molecule	approved
40	DB00439	Cerivastatin	small molecule	withdrawn
41	DB00608	Chloroquine	small molecule	approved
42	DB00477	Chlorpromazine	small molecule	approved
43	DB00672	Chlorpropamide	small molecule	approved
44	DB01239	Chlorprothixene	small molecule	approved
45	DB04540	Cholesterol	small molecule	experimental
46	DB02659	Cholic Acid	small molecule	experimental
47	DB01340	Cilazapril	small molecule	approved
48	DB00501	Cimetidine	small molecule	approved
49	DB00537	Ciprofloxacin	small molecule	approved, investigational
50	DB00515	Cisplatin	small molecule	approved
51	DB00215	Citalopram	small molecule	approved
52	DB01211	Clarithromycin	small molecule	approved
53	DB00349	Clobazam	small molecule	illicit, approved
54	DB00845	Clofazimine	small molecule	approved
55	DB00882	Clomifene	small molecule	approved, investigational
56	DB01242	Clomipramine	small molecule	approved
57	DB00575	Clonidine	small molecule	approved
58	DB00257	Clotrimazole	small molecule	approved
59	DB00363	Clozapine	small molecule	approved
60	DB01394	Colchicine	small molecule	approved
61	DB00286	Conjugated Estrogens	small molecule	approved
62	DB00531	Cyclophosphamide	small molecule	approved, investigational
63	DB00091	Cyclosporine	biotech	approved, investigational
64	DB06695	Dabigatran etexilate	small molecule	approved
65	DB00970	Dactinomycin	small molecule	approved
66	DB01254	Dasatinib	small molecule	approved, investigational
67	DB00694	Daunorubicin	small molecule	approved
68	DB04840	Debrisoquin	small molecule	approved
69	DB01151	Desipramine	small molecule	approved
70	DB00967	Desloratadine	small molecule	approved, investigational
71	DB01234	Dexamethasone	small molecule	approved, investigational
72	DB00514	Dextromethorphan	small molecule	approved
73	DB00829	Diazepam	small molecule	illicit, approved
74	DB00586	Diclofenac	small molecule	approved
75	DB00255	Diethylstilbestrol	small molecule	approved
76	DB01396	Digitoxin	small molecule	approved
77	DB00390	Digoxin	small molecule	approved
78	DB00320	Dihydroergotamine	small molecule	approved
79	DB02901	Dihydrotestosterone	small molecule	illicit, experimental
80	DB00343	Diltiazem	small molecule	approved
81	DB00975	Dipyridamole	small molecule	approved
82	DB01248	Docetaxel	small molecule	approved, investigational
83	DB01184	Domperidone	small molecule	approved
84	DB00590	Doxazosin	small molecule	approved
85	DB01142	Doxepin	small molecule	approved
86	DB00997	Doxorubicin	small molecule	approved, investigational
87	DB00470	Dronabinol	small molecule	illicit, approved
88	DB00216	Eletriptan	small molecule	approved, investigational
89	DB00584	Enalapril	small molecule	approved
90	DB00751	Epinastine	small molecule	approved, investigational
91	DB01253	Ergonovine	small molecule	approved
92	DB00696	Ergotamine	small molecule	approved
93	DB00530	Erlotinib	small molecule	approved, investigational
94	DB00199	Erythromycin	small molecule	approved
95	DB00783	Estradiol	small molecule	approved, investigational
96	DB01196	Estramustine	small molecule	approved
97	DB04573	Estriol	small molecule	approved
98	DB00655	Estrone	small molecule	approved
99	DB00977	Ethinyl Estradiol	small molecule	approved
100	DB00773	Etoposide	small molecule	approved
101	DB00973	Ezetimibe	small molecule	approved
102	DB01023	Felodipine	small molecule	approved, investigational
103	DB00813	Fentanyl	small molecule	illicit, approved, investigational
104	DB06702	Fesoterodine	small molecule	approved
105	DB00950	Fexofenadine	small molecule	approved
106	DB08874	Fidaxomicin	small molecule	approved
107	DB00196	Fluconazole	small molecule	approved
108	DB00472	Fluoxetine	small molecule	approved
109	DB00875	Flupenthixol	small molecule	approved
110	DB00623	Fluphenazine	small molecule	approved
111	DB00690	Flurazepam	small molecule	illicit, approved
112	DB00176	Fluvoxamine	small molecule	approved, investigational
113	DB02587	Forskolin	small molecule	experimental
114	DB00317	Gefitinib	small molecule	approved, investigational
115	DB00441	Gemcitabine	small molecule	approved
116	DB01645	Genistein	small molecule	experimental
117	DB01016	Glyburide	small molecule	approved
118	DB04077	Glycerol	small molecule	experimental
119	DB00027	Gramicidin D	biotech	approved
120	DB00365	Grepafloxacin	small molecule	approved, withdrawn
121	DB00502	Haloperidol	small molecule	approved
122	DB00741	Hydrocortisone	small molecule	approved
123	DB01050	Ibuprofen	small molecule	approved
124	DB00619	Imatinib	small molecule	approved
125	DB00458	Imipramine	small molecule	approved
126	DB05039	Indacaterol	small molecule	approved
127	DB00224	Indinavir	small molecule	approved
128	DB00328	Indomethacin	small molecule	approved, investigational
129	DB01167	Itraconazole	small molecule	approved, investigational
130	DB00602	Ivermectin	small molecule	approved
131	DB01221	Ketamine	small molecule	approved
132	DB01587	Ketazolam	small molecule	approved
133	DB01026	Ketoconazole	small molecule	approved, investigational
134	DB00555	Lamotrigine	small molecule	approved, investigational
135	DB00448	Lansoprazole	small molecule	approved, investigational
136	DB01259	Lapatinib	small molecule	approved, investigational
137	DB01202	Levetiracetam	small molecule	approved, investigational
138	DB01137	Levofloxacin	small molecule	approved, investigational
139	DB00451	Levothyroxine	small molecule	approved
140	DB00281	Lidocaine	small molecule	approved
141	DB08882	Linagliptin	small molecule	approved
142	DB00279	Liothyronine	small molecule	approved
143	DB01583	Liotrix	small molecule	approved
144	DB00722	Lisinopril	small molecule	approved, investigational
145	DB00836	Loperamide	small molecule	approved
146	DB01601	Lopinavir	small molecule	approved
147	DB00455	Loratadine	small molecule	approved
148	DB00678	Losartan	small molecule	approved
149	DB00227	Lovastatin	small molecule	approved, investigational
150	DB00742	Mannitol	small molecule	approved, investigational
151	DB00934	Maprotiline	small molecule	approved
152	DB00643	Mebendazole	small molecule	approved
153	DB00358	Mefloquine	small molecule	approved
154	DB00351	Megestrol	small molecule	approved
155	DB00371	Meprobamate	small molecule	illicit, approved
156	DB00333	Methadone	small molecule	approved
157	DB00563	Methotrexate	small molecule	approved
158	DB00959	Methylprednisolone	small molecule	approved
159	DB00264	Metoprolol	small molecule	approved, investigational
160	DB01388	Mibefradil	small molecule	withdrawn
161	DB01110	Miconazole	small molecule	approved, investigational
162	DB00683	Midazolam	small molecule	illicit, approved
163	DB00834	Mifepristone	small molecule	approved
164	DB00305	Mitomycin	small molecule	approved
165	DB01204	Mitoxantrone	small molecule	approved, investigational
166	DB00295	Morphine	small molecule	approved, investigational
167	DB01203	Nadolol	small molecule	approved
168	DB01183	Naloxone	small molecule	approved
169	DB00704	Naltrexone	small molecule	approved, investigational
170	DB03467	Naringenin	small molecule	experimental
171	DB01149	Nefazodone	small molecule	approved, withdrawn
172	DB00220	Nelfinavir	small molecule	approved
173	DB01400	Neostigmine	small molecule	approved
174	DB00622	Nicardipine	small molecule	approved
175	DB01115	Nifedipine	small molecule	approved
176	DB04868	Nilotinib	small molecule	approved, investigational
177	DB00401	Nisoldipine	small molecule	approved
178	DB01595	Nitrazepam	small molecule	approved
179	DB01054	Nitrendipine	small molecule	approved
180	DB00585	Nizatidine	small molecule	approved
181	DB00717	Norethindrone	small molecule	approved
182	DB00334	Olanzapine	small molecule	approved, investigational
183	DB00338	Omeprazole	small molecule	approved, investigational
184	DB04417	P-Nitrophenol	small molecule	experimental
185	DB01229	Paclitaxel	small molecule	approved
186	DB03796	Palmitic Acid	small molecule	experimental
187	DB00213	Pantoprazole	small molecule	approved
188	DB00715	Paroxetine	small molecule	approved, investigational
189	DB06589	Pazopanib	small molecule	approved
190	DB00790	Perindopril	small molecule	approved
191	DB01174	Phenobarbital	small molecule	approved
192	DB00252	Phenytoin	small molecule	approved
193	DB01100	Pimozide	small molecule	approved
194	DB08860	Pitavastatin	small molecule	approved
195	DB02261	Platelet Activating Factor	small molecule	experimental
196	DB01263	Posaconazole	small molecule	approved, investigational
197	DB00175	Pravastatin	small molecule	approved
198	DB00457	Prazosin	small molecule	approved
199	DB00860	Prednisolone	small molecule	approved
200	DB00635	Prednisone	small molecule	approved
201	DB01032	Probenecid	small molecule	approved
202	DB00396	Progesterone	small molecule	approved
203	DB01069	Promethazine	small molecule	approved
204	DB01182	Propafenone	small molecule	approved
205	DB00571	Propranolol	small molecule	approved, investigational
206	DB00344	Protriptyline	small molecule	approved
207	DB04216	Quercetin	small molecule	experimental
208	DB01224	Quetiapine	small molecule	approved
209	DB01103	Quinacrine	small molecule	approved
210	DB00908	Quinidine	small molecule	approved
211	DB00468	Quinine	small molecule	approved
212	DB00863	Ranitidine	small molecule	approved
213	DB00234	Reboxetine	small molecule	approved, investigational
214	DB00206	Reserpine	small molecule	approved
215	DB01045	Rifampin	small molecule	approved
216	DB08864	Rilpivirine	small molecule	approved
217	DB00734	Risperidone	small molecule	approved, investigational
218	DB00503	Ritonavir	small molecule	approved, investigational
219	DB06228	Rivaroxaban	small molecule	approved
220	DB00778	Roxithromycin	small molecule	approved
221	DB00936	Salicyclic acid	small molecule	approved
222	DB01232	Saquinavir	small molecule	approved, investigational
223	DB00747	Scopolamine	small molecule	approved
224	DB01037	Selegiline	small molecule	approved, investigational
225	DB01104	Sertraline	small molecule	approved
226	DB00641	Simvastatin	small molecule	approved
227	DB00877	Sirolimus	small molecule	approved, investigational
228	DB01261	Sitagliptin	small molecule	approved, investigational
229	DB00398	Sorafenib	small molecule	approved, investigational
230	DB01208	Sparfloxacin	small molecule	approved
231	DB03203	Sphingosine	small molecule	experimental
232	DB00421	Spironolactone	small molecule	approved
233	DB01323	St. John's Wort	small molecule	nutraceutical
234	DB02010	Staurosporine	small molecule	experimental
235	DB00428	Streptozocin	small molecule	approved
236	DB01138	Sulfinpyrazone	small molecule	approved
237	DB00669	Sumatriptan	small molecule	approved, investigational
238	DB01268	Sunitinib	small molecule	approved, investigational
239	DB00382	Tacrine	small molecule	approved
240	DB00864	Tacrolimus	small molecule	approved, investigational
241	DB00675	Tamoxifen	small molecule	approved
242	DB04348	Taurocholic Acid	small molecule	experimental
243	DB05521	Telaprevir	small molecule	approved
244	DB00966	Telmisartan	small molecule	approved, investigational
245	DB06287	Temsirolimus	small molecule	approved, investigational
246	DB01162	Terazosin	small molecule	approved
247	DB00342	Terfenadine	small molecule	approved, withdrawn
248	DB00624	Testosterone	small molecule	approved, investigational
249	DB02791	Tetraphenylphosphonium	small molecule	experimental
250	DB00373	Timolol	small molecule	approved
251	DB01030	Topotecan	small molecule	approved, investigational
252	DB00539	Toremifene	small molecule	approved, investigational
253	DB00656	Trazodone	small molecule	approved, investigational
254	DB00831	Trifluoperazine	small molecule	approved
255	DB00508	Triflupromazine	small molecule	approved
256	DB00440	Trimethoprim	small molecule	approved
257	DB00726	Trimipramine	small molecule	approved
258	DB01361	Troleandomycin	small molecule	approved
259	DB01339	Vecuronium	small molecule	approved
260	DB00285	Venlafaxine	small molecule	approved
261	DB00661	Verapamil	small molecule	approved
262	DB00570	Vinblastine	small molecule	approved
263	DB00541	Vincristine	small molecule	approved, investigational
264	DB00361	Vinorelbine	small molecule	approved, investigational
265	DB04877	Voacamine	small molecule	approved, investigational
266	DB04832	Zimelidine	small molecule	withdrawn