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Lymphotoxin-alpha

ID 1789
Name Lymphotoxin-alpha
Synonyms
  • LT-alpha
  • TNF-beta
  • Tumor necrosis factor ligand superfamily member 1
  • Lymphotoxin-alpha precursor
Gene Name LTA
Protein Sequence 
>Lymphotoxin-alpha precursor
MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST
LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY
SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ
LSTHTDGIPHLVLSPSTVFFGAFAL
Number of Residues 205
Molecular Weight 22297
Theoretical pI 9.36
GO Classification
Component
cell
membrane
Function
signal transducer activity
receptor binding
cytokine activity
tumor necrosis factor receptor binding
Process
response to stimulus
response to biotic stimulus
defense response
immune response
General Function Involved in tumor necrosis factor receptor binding
Specific Function Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo
Pathways Not Available
Reactions Not Available
Pfam Domain Function
Signals 1-34
Transmembrane Regions None
Essentiality Non-Essential
GenBank Protein ID 34445 Link_out
UniProtKB ID P01374 Link_out
UniProtKB Entry Name TNFB_HUMAN Link_out
PDB ID 1TNR Link_out
PDB File show
3D Structure View 3D Structure
Cellular Location Homotrimer:Secreted protein. Heterotrimer:Membrane
Gene Sequence 
>618 bp
ATGACACCACCTGAACGTCTCTTCCTCCCAAGGGTGTGTGGCACCACCCTACACCTCCTC
CTTCTGGGGCTGCTGCTGGTTCTGCTGCCTGGGGCCCAGGGGCTCCCTGGTGTTGGCCTC
ACACCTTCAGCTGCCCAGACTGCCCGTCAGCACCCCAAGATGCATCTTGCCCACAGCACC
CTCAAACCTGCTGCTCACCTCATTGGAGACCCCAGCAAGCAGAACTCACTGCTCTGGAGA
GCAAACACGGACCGTGCCTTCCTCCAGGATGGTTTCTCCTTGAGCAACAATTCTCTCCTG
GTCCCCACCAGTGGCATCTACTTCGTCTACTCCCAGGTGGTCTTCTCTGGGAAAGCCTAC
TCTCCCAAGGCCACCTCCTCCCCACTCTACCTGGCCCATGAGGTCCAGCTCTTCTCCTCC
CAGTACCCCTTCCATGTGCCTCTCCTCAGCTCCCAGAAGATGGTGTATCCAGGGCTGCAG
GAACCCTGGCTGCACTCGATGTACCACGGGGCTGCGTTCCAGCTCACCCAGGGAGACCAG
CTATCCACCCACACAGATGGCATCCCCCACCTAGTCCTCAGCCCTAGTACTGTCTTCTTT
GGAGCCTTCGCTCTGTAG
GenBank Gene ID X01393 Link_out
GeneCard ID LTA Link_out
GenAtlas ID LTA Link_out
HGNC ID HGNC:6709 Link_out
HPRD ID 01084
IUPHAR ID Not Available
Guide to Pharmacology ID Not Available
Chromosome Location Not Available
Locus 6p21.3
SNPs LTA Link_out
General References
  1. Nedospasov SA, Shakhov AN, Turetskaya RL, Mett VA, Azizov MM, Georgiev GP, Korobko VG, Dobrynin VN, Filippov SA, Bystrov NS, et al.: Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome. Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:611-24. Pubmed
  2. Nedwin GE, Jarrett-Nedwin J, Smith DH, Naylor SL, Sakaguchi AY, Goeddel DV, Gray PW: Structure and chromosomal localization of the human lymphotoxin gene. J Cell Biochem. 1985;29(3):171-81. Pubmed
  3. Kobayashi Y, Miyamoto D, Asada M, Obinata M, Osawa T: Cloning and expression of human lymphotoxin mRNA derived from a human T cell hybridoma. J Biochem (Tokyo). 1986 Sep;100(3):727-33. Pubmed
  4. Gray PW, Aggarwal BB, Benton CV, Bringman TS, Henzel WJ, Jarrett JA, Leung DW, Moffat B, Ng P, Svedersky LP, et al.: Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity. Nature. 1984 Dec 20-1985 Jan 2;312(5996):721-4. Pubmed
  5. Matsuyama N, Okawa N, Tsukii Y, Endo T, Kaji A: Nucleotide sequence of a cDNA encoding human tumor necrosis factor beta from B lymphoblastoid cell RPMI 1788. FEBS Lett. 1992 May 11;302(2):141-4. Pubmed
  6. Iris FJ, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, Jurka J, Rodriguez-Tome P, Claverie JM, Dausset J, et al.: Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. Nat Genet. 1993 Feb;3(2):137-45. Pubmed
  7. Neville MJ, Campbell RD: A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. J Immunol. 1999 Apr 15;162(8):4745-54. Pubmed
  8. Voigt CG, Maurer-Fogy I, Adolf GR: Natural human tumor necrosis factor beta (lymphotoxin). Variable O-glycosylation at Thr7, proteolytic processing, and allelic variation. FEBS Lett. 1992 Dec 7;314(1):85-8. Pubmed
  9. Eck MJ, Ultsch M, Rinderknecht E, de Vos AM, Sprang SR: The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution. J Biol Chem. 1992 Feb 5;267(4):2119-22. Pubmed
  10. Banner DW, D’Arcy A, Janes W, Gentz R, Schoenfeld HJ, Broger C, Loetscher H, Lesslauer W: Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell. 1993 May 7;73(3):431-45. Pubmed
  11. Messer G, Spengler U, Jung MC, Honold G, Blomer K, Pape GR, Riethmuller G, Weiss EH: Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. J Exp Med. 1991 Jan 1;173(1):209-19. Pubmed
  12. Abraham LJ, Du DC, Zahedi K, Dawkins RL, Whitehead AS: Haplotypic polymorphisms of the TNFB gene. Immunogenetics. 1991;33(1):50-3. Pubmed
Drugs
# DrugBank ID Drug Name Drug Type Drug Groups
1 DB00005 Etanercept biotech approved, investigational