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High affinity immunoglobulin epsilon receptor subunit alpha

ID 18
Name High affinity immunoglobulin epsilon receptor subunit alpha
Synonyms
  • FcERI
  • IgE Fc receptor, alpha-subunit
  • Fc-epsilon RI-alpha
  • High affinity immunoglobulin epsilon receptor subunit alpha precursor
Gene Name FCER1A
Protein Sequence 
>High affinity immunoglobulin epsilon receptor alpha-subunit precursor
MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVS
STKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAE
VVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKV
WQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTR
KGFRLLNPHPKPNPKNN
Number of Residues 257
Molecular Weight 29596
Theoretical pI 6.67
GO Classification Not Available
General Function Not Available
Specific Function Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines
Pathways Not Available
Reactions Not Available
Pfam Domain Function
Signals 1-25
Transmembrane Regions 206-224
Essentiality Non-Essential
GenBank Protein ID 31318 Link_out
UniProtKB ID P12319 Link_out
UniProtKB Entry Name FCERA_HUMAN Link_out
PDB ID 1RPQ Link_out
PDB File show
3D Structure View 3D Structure
Cellular Location Membrane; single-pass type I membrane protein
Gene Sequence 
>774 bp
ATGGCTCCTGCCATGGAATCCCCTACTCTACTGTGTGTAGCCTTACTGTTCTTCGCTCCA
GATGGCGTGTTAGCAGTCCCTCAGAAACCTAAGGTCTCCTTGAACCCTCCATGGAATAGA
ATATTTAAAGGAGAGAATGTGACTCTTACATGTAATGGGAACAATTTCTTTGAAGTCAGT
TCCACCAAATGGTTCCACAATGGCAGCCTTTCAGAAGAGACAAATTCAAGTTTGAATATT
GTGAATGCCAAATTTGAAGACAGTGGAGAATACAAATGTCAGCACCAACAAGTTAATGAG
AGTGAACCTGTGTACCTGGAAGTCTTCAGTGACTGGCTGCTCCTTCAGGCCTCTGCTGAG
GTGGTGATGGAGGGCCAGCCCCTCTTCCTCAGGTGCCATGGTTGGAGGAACTGGGATGTG
TACAAGGTGATCTATTATAAGGATGGTGAAGCTCTCAAGTACTGGTATGAGAACCACAAC
ATCTCCATTACAAATGCCACAGTTGAAGACAGTGGAACCTACTACTGTACGGGCAAAGTG
TGGCAGCTGGACTATGAGTCTGAGCCCCTCAACATTACTGTAATAAAAGCTCCGCGTGAG
AAGTACTGGCTACAATTTTTTATCCCATTGTTGGTGGTGATTCTGTTTGCTGTGGACACA
GGATTATTTATCTCAACTCAGCAGCAGGTCACATTTCTCTTGAAGATTAAGAGAACCAGG
AAAGGCTTCAGACTTCTGAACCCACATCCTAAGCCAAACCCCAAAAACAACTGA
GenBank Gene ID X06948 Link_out
GeneCard ID FCER1A Link_out
GenAtlas ID FCER1A Link_out
HGNC ID HGNC:3609 Link_out
HPRD ID 00917
IUPHAR ID Not Available
Guide to Pharmacology ID Not Available
Chromosome Location Not Available
Locus 1q23
SNPs FCER1A Link_out
General References
  1. Kochan J, Pettine LF, Hakimi J, Kishi K, Kinet JP: Isolation of the gene coding for the alpha subunit of the human high affinity IgE receptor. Nucleic Acids Res. 1988 Apr 25;16(8):3584. Pubmed
  2. Shimizu A, Tepler I, Benfey PN, Berenstein EH, Siraganian RP, Leder P: Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1907-11. Pubmed
  3. Yagi S, Yanagida M, Tanida I, Hasegawa A, Okumura K, Ra C: High-level expression of the truncated alpha chain of human high-affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product. Eur J Biochem. 1994 Mar 1;220(2):593-8. Pubmed
  4. Padlan EA, Helm BA: A modeling study of the alpha-subunit of human high-affinity receptor for immunoglobulin-E. Receptor. 1992 Summer;2(2):129-44. Pubmed
Drugs
# DrugBank ID Drug Name Drug Type Drug Groups
1 DB02944 Alpha-D-Mannose small molecule experimental
2 DB00895 Benzylpenicilloyl Polylysine small molecule approved
3 DB00043 Omalizumab biotech approved, investigational