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Prostaglandin G/H synthase 1

ID 20
Name Prostaglandin G/H synthase 1
Synonyms
  • EC 1.14.99.1
  • Cyclooxygenase- 1
  • COX-1
  • Prostaglandin-endoperoxide synthase 1
  • Prostaglandin H2 synthase 1
  • PGH synthase 1
  • PGHS-1
  • PHS 1
  • Prostaglandin G/H synthase 1 precursor
Gene Name PTGS1
Protein Sequence 
>Prostaglandin G/H synthase 1 precursor
MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
Number of Residues 599
Molecular Weight 68657
Theoretical pI 7.39
GO Classification
Function
antioxidant activity
peroxidase activity
General Function Involved in peroxidase activity
Specific Function May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells
Pathways
Name SMPDB Link KEGG Link
Piroxicam Pathway SMP00077
Acetylsalicylic Acid Pathway SMP00083
Etodolac Pathway SMP00084
Ketoprofen Pathway SMP00085
Ibuprofen Pathway SMP00086
Rofecoxib Pathway SMP00087
Diclofenac Pathway SMP00093
Sulindac Pathway SMP00094
Celecoxib Pathway SMP00096
Ketorolac Pathway SMP00098
Suprofen Pathway SMP00101
Bromfenac Pathway SMP00102
Indomethacin Pathway SMP00104
Meloxicam Pathway SMP00106
Mefanamic Acid Pathway SMP00109
Oxaprozin Pathway SMP00113
Nabumetone Pathway SMP00114
Valdecoxib Pathway SMP00116
Naproxen Pathway SMP00120
Clopidogrel Pathway SMP00260
Ticlopidine Pathway SMP00261
Cilostazol Pathway SMP00263
Dipyridamole (Antiplatelet) Pathway SMP00264
Abciximab Pathway SMP00265
Eptifibatide Pathway SMP00266
Tirofiban Pathway SMP00267
Diflunisal Pathway SMP00289
Reactions
  • arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
Pfam Domain Function
Signals 1-23
Transmembrane Regions None
Essentiality Non-Essential
GenBank Protein ID 387018 Link_out
UniProtKB ID P23219 Link_out
UniProtKB Entry Name PGH1_HUMAN Link_out
PDB ID Not Available
Cellular Location Microsome; microsomal membrane; peripheral membrane protein
Gene Sequence 
>1800 bp
ATGAGCCGGAGTCTCTTGCTCCGGTTCTTGCTGTTGCTGCTCCTGCTCCCGCCGCTCCCC
GTCCTGCTCGCGGACCCAGGGGCGCCCACGCCAGTGAATCCCTGTTGTTACTATCCATGC
CAGCACCAGGGCATCTGTGTCCGCTTCGGCCTTGACCGCTACCAGTGTGACTGCACCCGC
ACGGGCTATTCCGGCCCCAACTGCACCATCCCTGGCCTGTGGACCTGGCTCCGGAATTCA
CTGCGGCCCAGCCCCTCTTTCACCCACTTCCTGCTCACTCACGGGCGCTGGTTCTGGGAG
TTTGTCAATGCCACCTTCATCCGAGAGATGCTCATGCTCCTGGTACTCACAGTGCGCTCC
AACCTTATCCCCAGTCCCCCCACCTACAACTCTGCACATGACTACATCAGCTGGGAGTCT
TTCTCCAACGTGAGCTATTACACTCGTATTCTGCCCTCTGTGCCTAAAGATTGCCCCACA
CCCATGGGAACCAAAGGGAAGAAGCAGTTGCCAGATGCCCAGCTCCTGGCCCGCCGCTTC
CTGCTCAGGAGGAAGTTCATACCTGACCCCCAAGGCACCAACCTCATGTTTGCCTTCTTT
GCACAACACTTCACCCACCAGTTCTTCAAAACTTCTGGCAAGATGGGTCCTGGCTTCACC
AAGGCCTTGGGCCATGGGGTAGACCTCGGCCACATTTATGGAGACAATCTGGAGCGTCAG
TATCAACTGCGGCTCTTTAAGGATGGGAAACTCAAGTACCAGGTGCTGGATGGAGAAATG
TACCCGCCCTCGGTAGAAGAGGCGCCTGTGTTGATGCACTACCCCCGAGGCATCCCGCCC
CAGAGCCAGATGGCTGTGGGCCAGGAGGTGTTTGGGCTGCTTCCTGGGCTCATGCTGTAT
GCCACGCTCTGGCTACGTGAGCACAACCGTGTGTGTGACCTGCTGAAGGCTGAGCACCCC
ACCTGGGGCGATGAGCAGCTTTTCCAGACGACCCGCCTCATCCTCATAGGGGAGACCATC
AAGATTGTCATCGAGGAGTACGTGCAGCAGCTGAGTGGCTATTTCCTGCAGCTGAAATTT
GACCCAGAGCTGCTGTTCGGTGTCCAGTTCCAATACCGCAACCGCATTGCCACGGAGTTC
AACCATCTCTACCACTGGCACCCCCTCATGCCTGACTCCTTCAAGGTGGGCTCCCAGGAG
TACAGCTACGAGCAGTTCTTGTTCAACACCTCCATGTTGGTGGACTATGGGGTTGAGGCC
CTGGTGGATGCCTTCTCTCGCCAGATTGCTGGCCGGATCGGTGGGGGCAGGAACATGGAC
CACCACATCCTGCATGTGGCTGTGGATGTCATCAGGGAGTCTCGGGAGATGCGGCTGCAG
CCCTTCAATGAGTACCGCAAGAGGTTTGGCATGAAACCCTACACCTCCTTCCAGGAGCTC
GTAGGAGAGAAGGAGATGGCAGCAGAGTTGGAGGAATTGTATGGAGACATTGATGCGTTG
GAGTTCTACCCTGGACTGCTTCTTGAAAAGTGCCATCCAAACTCTATCTTTGGGGAGAGT
ATGATAGAGATTGGGGCTCCCTTTTCCCTCAAGGGTCTCCTAGGGAATCCCATCTGTTCT
CCGGAGTACTGGAAGCCGAGCACATTTGGCGGCGAGGTGGGCTTTAACATTGTCAAGACG
GCCACACTGAAGAAGCTGGTCTGCCTCAACACCAAGACCTGTCCCTACGTTTCCTTCCGT
GTGCCGGATGCCAGTCAGGATGATGGGCCTGCTGTGGAGCGACCATCCACAGAGCTCTGA
GenBank Gene ID M31822 Link_out
GeneCard ID PTGS1 Link_out
GenAtlas ID PTGS1 Link_out
HGNC ID HGNC:9604 Link_out
HPRD ID 07518
IUPHAR ID Not Available
Guide to Pharmacology ID Not Available
Chromosome Location Not Available
Locus 9q32-q33.3
SNPs PTGS1 Link_out
General References
  1. Yokoyama C, Tanabe T: Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochem Biophys Res Commun. 1989 Dec 15;165(2):888-94. Pubmed
  2. Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA: Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J. 1991 Jun;5(9):2304-12. Pubmed
  3. Takahashi Y, Ueda N, Yoshimoto T, Yamamoto S, Yokoyama C, Miyata A, Tanabe T, Fuse I, Hattori A, Shibata A: Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase). Biochem Biophys Res Commun. 1992 Jan 31;182(2):433-8. Pubmed
  4. Diaz A, Reginato AM, Jimenez SA: Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha. J Biol Chem. 1992 May 25;267(15):10816-22. Pubmed
Drugs
# DrugBank ID Drug Name Drug Type Drug Groups
1 DB02773 (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid small molecule experimental
2 DB07983 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID small molecule experimental
3 DB02047 2-(1,1'-Biphenyl-4-Yl)Propanoic Acid small molecule experimental
4 DB07981 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1R)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE small molecule experimental
5 DB07984 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1S)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE small molecule experimental
6 DB02198 2-Bromoacetyl Group small molecule experimental
7 DB00316 Acetaminophen small molecule approved
8 DB03667 Acetic Acid Salicyloyl-Amino-Ester small molecule experimental
9 DB00945 Acetylsalicylic acid small molecule approved
10 DB02944 Alpha-D-Mannose small molecule experimental
11 DB01435 Antipyrine small molecule approved
12 DB01419 Antrafenine small molecule approved
13 DB04557 Arachidonic Acid small molecule experimental
14 DB01014 Balsalazide small molecule approved, investigational
15 DB02379 Beta-D-Glucose small molecule experimental
16 DB02687 Beta-D-Mannose small molecule experimental
17 DB00188 Bortezomib small molecule approved, investigational
18 DB00963 Bromfenac small molecule approved
19 DB00796 Candesartan small molecule approved
20 DB00821 Carprofen small molecule approved
21 DB01136 Carvedilol small molecule approved, investigational
22 DB00672 Chlorpropamide small molecule approved
23 DB00250 Dapsone small molecule approved, investigational
24 DB00035 Desmopressin small molecule approved
25 DB00829 Diazepam small molecule illicit, approved
26 DB00586 Diclofenac small molecule approved
27 DB00711 Diethylcarbamazine small molecule approved
28 DB00861 Diflunisal small molecule approved
29 DB01075 Diphenhydramine small molecule approved
30 DB04817 Dipyrone small molecule withdrawn
31 DB00470 Dronabinol small molecule illicit, approved
32 DB00216 Eletriptan small molecule approved, investigational
33 DB00402 Eszopiclone small molecule approved
34 DB00749 Etodolac small molecule approved, investigational
35 DB00573 Fenoprofen small molecule approved
36 DB02266 Flufenamic Acid small molecule experimental
37 DB00712 Flurbiprofen small molecule approved
38 DB03753 Flurbiprofen Methyl Ester small molecule experimental
39 DB00154 gamma-Homolinolenic acid small molecule approved, nutraceutical
40 DB03014 Heme small molecule experimental
41 DB01355 Hexobarbital small molecule approved
42 DB00327 Hydromorphone small molecule illicit, approved
43 DB01892 Hyperforin small molecule nutraceutical
44 DB01050 Ibuprofen small molecule approved
45 DB00159 Icosapent small molecule approved, nutraceutical
46 DB01181 Ifosfamide small molecule approved
47 DB00619 Imatinib small molecule approved
48 DB00328 Indomethacin small molecule approved, investigational
49 DB01029 Irbesartan small molecule approved, investigational
50 DB01221 Ketamine small molecule approved
51 DB01009 Ketoprofen small molecule approved
52 DB00465 Ketorolac small molecule approved
53 DB06725 Lornoxicam small molecule approved
54 DB01283 Lumiracoxib small molecule approved, investigational
55 DB01397 Magnesium salicylate small molecule approved
56 DB00939 Meclofenamic acid small molecule approved
57 DB00784 Mefenamic acid small molecule approved
58 DB00814 Meloxicam small molecule approved
59 DB00244 Mesalazine small molecule approved
60 DB00350 Minoxidil small molecule approved
61 DB00471 Montelukast small molecule approved
62 DB00461 Nabumetone small molecule approved
63 DB00788 Naproxen small molecule approved
64 DB00731 Nateglinide small molecule approved, investigational
65 DB06802 Nepafenac small molecule approved
66 DB04552 Niflumic Acid small molecule approved
67 DB00540 Nortriptyline small molecule approved
68 DB01837 O-Acetylserine small molecule experimental
69 DB00991 Oxaprozin small molecule approved
70 DB03752 P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid small molecule experimental
71 DB03783 Phenacetin small molecule withdrawn
72 DB00812 Phenylbutazone small molecule approved
73 DB01132 Pioglitazone small molecule approved, investigational
74 DB00554 Piroxicam small molecule approved, investigational
75 DB02110 Protoporphyrin Ix Containing Co small molecule experimental
76 DB02709 Resveratrol small molecule experimental, investigational
77 DB00533 Rofecoxib small molecule withdrawn, investigational
78 DB00412 Rosiglitazone small molecule approved, investigational
79 DB00936 Salicyclic acid small molecule approved
80 DB01398 Salicylate-sodium small molecule approved
81 DB01399 Salsalate small molecule approved
82 DB01015 Sulfamethoxazole small molecule approved
83 DB00795 Sulfasalazine small molecule approved
84 DB00605 Sulindac small molecule approved
85 DB00870 Suprofen small molecule approved
86 DB00469 Tenoxicam small molecule approved
87 DB00857 Terbinafine small molecule approved, investigational
88 DB01041 Thalidomide small molecule approved, withdrawn, investigational
89 DB01600 Tiaprofenic acid small molecule approved
90 DB00500 Tolmetin small molecule approved
91 DB00214 Torasemide small molecule approved
92 DB05109 Trabectedin small molecule approved, investigational
93 DB08814 Triflusal small molecule approved
94 DB01401 Trisalicylate-choline small molecule approved
95 DB00580 Valdecoxib small molecule withdrawn, investigational
96 DB00313 Valproic Acid small molecule approved, investigational
97 DB00582 Voriconazole small molecule approved, investigational
98 DB00549 Zafirlukast small molecule approved, investigational
99 DB00744 Zileuton small molecule approved, investigational
100 DB00425 Zolpidem small molecule approved
101 DB01198 Zopiclone small molecule approved