| ID |
226 |
| Name |
Gonadotropin-releasing hormone receptor |
| Synonyms |
|
| Gene Name |
GNRHR |
| Protein Sequence |
>Gonadotropin-releasing hormone receptor
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
|
| Number of Residues |
328 |
| Molecular Weight |
37731 |
| Theoretical pI |
9.93 |
| GO Classification |
| Component |
| cell |
| intrinsic to membrane |
| integral to membrane |
| membrane |
| Function |
| protein-hormone receptor activity |
| gonadotropin-releasing hormone receptor activity |
| signal transducer activity |
| receptor activity |
| transmembrane receptor activity |
| G-protein coupled receptor activity |
| rhodopsin-like receptor activity |
| Process |
| cell communication |
| signal transduction |
| cell surface receptor linked signal transduction |
| G-protein coupled receptor protein signaling pathway |
| cellular process |
|
| General Function |
Involved in rhodopsin-like receptor activity |
| Specific Function |
Receptor for gonadotropin releasing hormone (GnRH) that mediate the action of GnRH to stimulate the secretion of the gonadotropic hormones (LH and FSH). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act a an inhibitor of GnRH-R signaling |
| Pathways |
Not Available |
| Reactions |
Not Available |
| Pfam Domain Function |
|
| Signals |
None |
| Transmembrane Regions |
39-58
78-97
116-137
165-184
213-232
282-300
307-326 |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
183422  |
| UniProtKB ID |
P30968 |
| UniProtKB Entry Name |
GNRHR_HUMAN |
| PDB ID |
Not Available |
| Cellular Location |
Membrane; multi-pass membrane protein |
| Gene Sequence |
>987 bp
ATGGCAAACAGTGCCTCTCCTGAACAGAATCAAAATCACTGTTCAGCCATCAACAACAGC
ATCCCACTGATGCAGGGCAACCTCCCCACTCTGACCTTGTCTGGAAAGATCCGAGTGACG
GTTACTTTCTTCCTTTTTCTGCTCTCTGCGACCTTTAATGCTTCTTTCTTGTTGAAACTT
CAGAAGTGGACACAGAAGAAAGAGAAAGGGAAAAAGCTCTCAAGAATGAAGCTGCTCTTA
AAACATCTGACCTTAGCCAACCTGTTGGAGACTCTGATTGTCATGCCACTGGATGGGATG
TGGAACATTACAGTCCAATGGTATGCTGGAGAGTTACTCTGCAAAGTTCTCAGTTATCTA
AAGCTTTTCTCCATGTATGCCCCAGCCTTCATGATGGTGGTGATCAGCCTGGACCGCTCC
CTGGCTATCACGAGGCCCCTAGCTTTGAAAAGCAACAGCAAAGTCGGACAGTCCATGGTT
GGCCTGGCCTGGATCCTCAGTAGTGTCTTTGCAGGACCACAGTTATACATCTTCAGGATG
ATTCATCTAGCAGACAGCTCTGGACAGACAAAAGTTTTCTCTCAATGTGTAACACACTGC
AGTTTTTCACAATGGTGGCATCAAGCATTTTATAACTTTTTCACCTTCAGCTGCCTCTTC
ATCATCCCTCTTTTCATCATGCTGATCTGCAATGCAAAAATCATCTTCACCCTGACACGG
GTCCTTCATCAGGACCCCCACGAACTACAACTGAATCAGTCCAAGAACAATATACCAAGA
GCACGGCTGAAGACTCTAAAAATGACGGTTGCATTTGCCACTTCATTTACTGTCTGCTGG
ACTCCCTACTATGTCCTAGGAATTTGGTATTGGTTTGATCCTGAAATGTTAAACAGGTTG
TCAGACCCAGTAAATCACTTCTTCTTTCTCTTTGCCTTTTTAAACCCATGCTTTGATCCA
CTTATCTATGGATATTTTTCTCTGTGA
|
| GenBank Gene ID |
L03380 |
| GeneCard ID |
GNRHR |
| GenAtlas ID |
GNRHR |
| HGNC ID |
HGNC:4421 |
| HPRD ID |
00732 |
| IUPHAR ID |
256 |
| Guide to Pharmacology ID |
31 |
| Chromosome Location |
Not Available |
| Locus |
4q21.2 |
| SNPs |
GNRHR |
| General References |
- Kakar SS, Musgrove LC, Devor DC, Sellers JC, Neill JD: Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor. Biochem Biophys Res Commun. 1992 Nov 30;189(1):289-95. Pubmed
- Chi L, Zhou W, Prikhozhan A, Flanagan C, Davidson JS, Golembo M, Illing N, Millar RP, Sealfon SC: Cloning and characterization of the human GnRH receptor. Mol Cell Endocrinol. 1993 Feb;91(1-2):R1-6. Pubmed
- Kakar SS, Grizzle WE, Neill JD: The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary. Mol Cell Endocrinol. 1994 Dec;106(1-2):145-9. Pubmed
- Kakar SS: Molecular structure of the human gonadotropin-releasing hormone receptor gene. Eur J Endocrinol. 1997 Aug;137(2):183-92. Pubmed
- Grosse R, Schoneberg T, Schultz G, Gudermann T: Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor. Mol Endocrinol. 1997 Aug;11(9):1305-18. Pubmed
- Kottler ML, Bergametti F, Carre MC, Morice S, Decoret E, Lagarde JP, Starzec A, Counis R: Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene. Eur J Endocrinol. 1999 Jun;140(6):561-9. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB00106 |
Abarelix |
biotech |
approved, withdrawn, investigational |
| 2 |
DB06719 |
Buserelin |
biotech |
approved |
| 3 |
DB00050 |
Cetrorelix |
small molecule |
approved, investigational |
| 4 |
DB01406 |
Danazol |
small molecule |
approved |
| 5 |
DB06699 |
Degarelix |
small molecule |
approved |
| 6 |
DB00644 |
Gonadorelin |
small molecule |
approved |
| 7 |
DB00014 |
Goserelin |
small molecule |
approved |
| 8 |
DB00007 |
Leuprolide |
biotech |
approved, investigational |
| 9 |
DB00666 |
Nafarelin |
small molecule |
approved |
|
