| ID |
2310 |
| Name |
2-dehydro-3-deoxyphosphooctonate aldolase |
| Synonyms |
- EC 2.5.1.55
- Phospho-2- dehydro-3-deoxyoctonate aldolase
- 3-deoxy-D-manno-octulosonic acid 8- phosphate synthetase
- KDO-8-phosphate synthetase
- KDO 8-P synthase
- KDOPS
|
| Gene Name |
kdsA |
| Protein Sequence |
>2-dehydro-3-deoxyphosphooctonate aldolase
MEKFLVIAGPCAIESEELLLKVGEEIKRLSEKFKEVEFVFKSSFDKANRSSIHSFRGHGL
EYGVKALRKVKEEFGLKITTDIHESWQAEPVAEVADIIQIPAFLCRQTDLLLAAAKTGRA
VNVKKGQFLAPWDTKNVVEKLKFGGAKEIYLTERGTTFGYNNLVVDFRSLPIMKQWAKVI
YDATHSVQLPGGLGDKSGGMREFIFPLIRAAVAVGCDGVFMETHPEPEKALSDASTQLPL
SQLEGIIEAILEIREVASKYYETIPVK
|
| Number of Residues |
267 |
| Molecular Weight |
29735 |
| Theoretical pI |
6.68 |
| GO Classification |
| Component |
| cell |
| intracellular |
| cytoplasm |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring alkyl or aryl (other than methyl) groups |
| 3-deoxy-8-phosphooctulonate synthase activity |
| Process |
| physiological process |
| metabolism |
| biosynthesis |
|
| General Function |
Cell wall/membrane/envelope biogenesis |
| Specific Function |
Phosphoenolpyruvate + D-arabinose 5-phosphate + H(2)O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate |
| Pathways |
Not Available |
| Reactions |
- phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
|
| Pfam Domain Function |
|
| Signals |
None |
| Transmembrane Regions |
None |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
2982835  |
| UniProtKB ID |
O66496 |
| UniProtKB Entry Name |
KDSA_AQUAE |
| PDB ID |
1PCW |
| PDB File |
show |
| 3D Structure |
View 3D Structure |
| Cellular Location |
Cytoplasm |
| Gene Sequence |
>804 bp
ATGGAAAAGTTTTTAGTGATAGCTGGACCCTGCGCGATAGAGAGCGAGGAACTTCTCCTA
AAGGTAGGGGAGGAGATAAAGCGTTTATCGGAGAAGTTCAAAGAAGTTGAGTTCGTATTT
AAGTCTTCCTTTGATAAAGCGAACCGCTCCTCAATACATTCCTTCAGGGGGCACGGTCTT
GAATACGGGGTAAAGGCTCTGAGGAAGGTAAAGGAAGAGTTCGGACTGAAGATTACCACG
GATATTCACGAGAGCTGGCAAGCTGAACCAGTTGCAGAAGTTGCGGACATAATCCAGATA
CCTGCCTTTTTATGCAGGCAGACTGACCTCCTCCTTGCGGCTGCAAAAACGGGAAGGGCT
GTAAACGTGAAGAAGGGTCAGTTTTTAGCCCCTTGGGACACGAAGAACGTGGTTGAAAAA
TTAAAGTTCGGCGGTGCTAAGGAGATATACCTCACGGAGAGAGGAACTACCTTCGGATAC
AACAACCTCGTTGTAGATTTCAGGAGCCTACCCATAATGAAACAGTGGGCAAAGGTTATA
TACGACGCCACCCACAGCGTCCAGCTCCCCGGAGGTCTCGGGGACAAATCAGGAGGAATG
AGGGAGTTTATATTCCCCTTAATCCGTGCTGCGGTTGCGGTAGGTTGTGACGGTGTGTTT
ATGGAAACACACCCAGAACCAGAAAAGGCACTCTCGGACGCATCAACTCAGCTTCCCCTC
TCCCAGCTGGAAGGGATAATAGAGGCTATCCTTGAGATAAGGGAAGTGGCTTCAAAGTAT
TACGAAACAATTCCCGTTAAATGA
|
| GenBank Gene ID |
AE000657 |
| GeneCard ID |
Not Available |
| GenAtlas ID |
Not Available |
| HGNC ID |
Not Available |
| HPRD ID |
Not Available |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
Not Available |
| SNPs |
kdsA |
| General References |
- Deckert G, Warren PV, Gaasterland T, Young WG, Lenox AL, Graham DE, Overbeek R, Snead MA, Keller M, Aujay M, Huber R, Feldman RA, Short JM, Olsen GJ, Swanson RV: The complete genome of the hyperthermophilic bacterium Aquifex aeolicus. Nature. 1998 Mar 26;392(6674):353-8. Pubmed
- Duewel HS, Sheflyan GY, Woodard RW: Functional and biochemical characterization of a recombinant 3-Deoxy-D-manno-octulosonic acid 8-phosphate synthase from the hyperthermophilic bacterium Aquifex aeolicus. Biochem Biophys Res Commun. 1999 Sep 24;263(2):346-51. Pubmed
- Wang J, Duewel HS, Stuckey JA, Woodard RW, Gatti DL: Function of His185 in Aquifex aeolicus 3-deoxy-D-manno-octulosonate 8-phosphate synthase. J Mol Biol. 2002 Nov 22;324(2):205-14. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB02433 |
{[(2,2-Dihydroxy-Ethyl)-(2,3,4,5-Tetrahydroxy-6-Phosphonooxy-Hexyl)-Amino]-Methyl}-Phosphonic Acid |
small molecule |
experimental |
| 2 |
DB02992 |
1-Deoxy-6-O-Phosphono-1-[(Phosphonomethyl)Amino]-L-Threo-Hexitol |
small molecule |
experimental |
| 3 |
DB03248 |
2-(Phosphonooxy)Butanoic Acid |
small molecule |
experimental |
| 4 |
DB01709 |
2-Phosphoglyceric Acid |
small molecule |
experimental |
| 5 |
DB03745 |
Arabinose-5-Phosphate |
small molecule |
experimental |
| 6 |
DB03937 |
Erythose-4-Phosphate |
small molecule |
experimental |
| 7 |
DB01819 |
Phosphoenolpyruvate |
small molecule |
experimental |
| 8 |
DB02053 |
Ribose-5-Phosphate |
small molecule |
experimental |
|
