| General References |
- Bolger G, Michaeli T, Martins T, St John T, Steiner B, Rodgers L, Riggs M, Wigler M, Ferguson K: A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol Cell Biol. 1993 Oct;13(10):6558-71. Pubmed
- Nemoz G, Zhang R, Sette C, Conti M: Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells. FEBS Lett. 1996 Apr 8;384(1):97-102. Pubmed
- Baecker PA, Obernolte R, Bach C, Yee C, Shelton ER: Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD). Gene. 1994 Jan 28;138(1-2):253-6. Pubmed
- Bolger GB, Erdogan S, Jones RE, Loughney K, Scotland G, Hoffmann R, Wilkinson I, Farrell C, Houslay MD: Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene. Biochem J. 1997 Dec 1;328 ( Pt 2):539-48. Pubmed
- Miro X, Casacuberta JM, Gutierrez-Lopez MD, de Landazuri MO, Puigdomenech P: Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1). Biochem Biophys Res Commun. 2000 Aug 2;274(2):415-21. Pubmed
- Wang D, Deng C, Bugaj-Gaweda B, Kwan M, Gunwaldsen C, Leonard C, Xin X, Hu Y, Unterbeck A, De Vivo M: Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7. Cell Signal. 2003 Sep;15(9):883-91. Pubmed
- Gretarsdottir S, Thorleifsson G, Reynisdottir ST, Manolescu A, Jonsdottir S, Jonsdottir T, Gudmundsdottir T, Bjarnadottir SM, Einarsson OB, Gudjonsdottir HM, Hawkins M, Gudmundsson G, Gudmundsdottir H, Andrason H, Gudmundsdottir AS, Sigurdardottir M, Chou TT, Nahmias J, Goss S, Sveinbjornsdottir S, Valdimarsson EM, Jakobsson F, Agnarsson U, Gudnason V, Thorgeirsson G, Fingerle J, Gurney M, Gudbjartsson D, Frigge ML, Kong A, Stefansson K, Gulcher JR: The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat Genet. 2003 Oct;35(2):131-8. Epub 2003 Sep 21. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB06842 |
(4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one |
small molecule |
experimental |
| 2 |
DB04149 |
(R)-Rolipram |
small molecule |
experimental |
| 3 |
DB03606 |
(S)-Rolipram |
small molecule |
experimental |
| 4 |
DB03183 |
1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester |
small molecule |
experimental |
| 5 |
DB04469 |
1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester |
small molecule |
experimental |
| 6 |
DB02676 |
2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol |
small molecule |
experimental |
| 7 |
DB07954 |
3-ISOBUTYL-1-METHYLXANTHINE |
small molecule |
experimental |
| 8 |
DB01959 |
3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester |
small molecule |
experimental |
| 9 |
DB07051 |
3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER |
small molecule |
experimental |
| 10 |
DB04271 |
3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester |
small molecule |
experimental |
| 11 |
DB01954 |
4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone |
small molecule |
experimental |
| 12 |
DB08299 |
4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid |
small molecule |
experimental |
| 13 |
DB02918 |
6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One |
small molecule |
experimental |
| 14 |
DB00131 |
Adenosine monophosphate |
small molecule |
approved, nutraceutical |
| 15 |
DB03849 |
Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid |
small molecule |
experimental |
| 16 |
DB00651 |
Dyphylline |
small molecule |
approved |
| 17 |
DB05266 |
Ibudilast |
small molecule |
approved, investigational |
| 18 |
DB01088 |
Iloprost |
small molecule |
approved, investigational |
| 19 |
DB00920 |
Ketotifen |
small molecule |
approved |
| 20 |
DB01791 |
Piclamilast |
small molecule |
experimental |
| 21 |
DB01656 |
Roflumilast |
small molecule |
approved |
|
