| ID |
256 |
| Name |
Tyrosyl-tRNA synthetase, cytoplasmic |
| Synonyms |
- EC 6.1.1.1
- Tyrosyl--tRNA ligase
- TyrRS
|
| Gene Name |
YARS |
| Protein Sequence |
>Tyrosyl-tRNA synthetase, cytoplasmic
GDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIAD
FLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGT
DYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDA
QFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDV
KKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAA
EVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPE
EVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVV
VLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEEL
KPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
|
| Number of Residues |
527 |
| Molecular Weight |
59013 |
| Theoretical pI |
7.05 |
| GO Classification |
| Function |
| RNA binding |
| ligase activity |
| binding |
| ligase activity, forming phosphoric ester bonds |
| RNA ligase activity |
| nucleotide binding |
| tRNA ligase activity |
| catalytic activity |
| purine nucleotide binding |
| adenyl nucleotide binding |
| tyrosine-tRNA ligase activity |
| ATP binding |
| tRNA binding |
| nucleic acid binding |
| Process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolism |
| physiological process |
| RNA metabolism |
| metabolism |
| tRNA metabolism |
| cellular metabolism |
| tRNA aminoacylation |
| tRNA aminoacylation for protein translation |
| tyrosyl-tRNA aminoacylation |
|
| General Function |
Translation, ribosomal structure and biogenesis |
| Specific Function |
Not Available |
| Pathways |
Not Available |
| Reactions |
- ATP + L-tyrosine + tRNATyr = AMP + diphosphate + L-tyrosyl-tRNATyr
|
| Pfam Domain Function |
|
| Signals |
None |
| Transmembrane Regions |
None |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
1184699  |
| UniProtKB ID |
P54577 |
| UniProtKB Entry Name |
SYYC_HUMAN |
| PDB ID |
1Q11 |
| PDB File |
show |
| 3D Structure |
View 3D Structure |
| Cellular Location |
Cytoplasm |
| Gene Sequence |
>1587 bp
ATGGGGGACGCTCCCAGCCCTGAAGAGAAACTGCACCTTATCACCCGGAACCTGCAGGAG
GTTCTGGGGGAAGAGAAGCTGAAGGAGATACTGAAGGAGCGGGAACTTAAAATTTACTGG
GGAACGGCAACCACGGGCAAACCACATGTGGCTTACTTTGTGCCCATGTCAAAGATTGCA
GACTTCTTAAAGGCAGGGTGTGAGGTAACAATTCTGTTTGCGGACCTCCACGCATACCTG
GATAACATGAAAGCCCCATGGGAACTTCTAGAACTCCGAGTCAGTTACTATGAGAATGTG
ATCAAAGCAATGCTGGAGAGCATTGGTGTGCCCTTGGAGAAGCTCAAGTTCATCAAAGGC
ACTGATTACCAGCTCAGCAAAGAGTACACACTAGATGTGTACAGACTCTCCTCCGTGGTC
ACACAGCACGATTCCAAGAAGGCTGGAGCTGAGGTGGTAAAGCAGGTGGAGCACCCTTTG
CTGAGTGGCCTCTTATACCCCGGACTGCAGGCTTTGGATGAAGAGTATTTAAAAGTAGAT
GCCCAATTTGGAGGCATTGATCAGAGAAAGATTTTCACCTTTGCAGAGAAGTACCTCCCT
GCACTTGGCTATTCAAAACGGGTCCATCTGATGAATCCTATGGTTCCAGGATTAACAGGC
AGCAAAATGAGCTCTTCAGAAGAGGAGTCCAAGATTGATCTCCTTGATCGGAAGGAGGAT
GTGAAGAAAAAACTGAAGAAGGCCTTCTGTGAGCCAGGAAATGTGGAGAACAATGGGGTT
CTGTCCTTCATCAAGCATGTCCTTTTTCCCCTTAAGTCCGAGTTTGTGATCCTACGAGAT
GAGAAATGGGGTGGAAACAAAACCTACACAGCTTACGTGGACCTGGAAAAGGACTTTGCT
GCTGAGGTTGTACATCCTGGAGACCTGAAGAATTCTGTTGAAGTCGCACTGAACAAGTTG
CTGGATCCAATCCGGGAAAAGTTTAATACCCCTGCCCTGAAAAAACTGGCCAGCGCTGCC
TACCCAGATCCCTCAAAGCAGAAGCCAATGGCCAAAGGCCCTGCCAAGAATTCAGAACCA
GAGGAGGTCATCCCATCCCGGCTGGATATCCGTGTGGGGAAAATCATCACTGTGGAGAAG
CACCCAGATGCAGACAGCCTGTATGTAGAGAAGATTGACGTGGGGGAAGCTGAACCACGG
ACTGTGGTGAGCGGCCTGGTACAGTTCGTGCCCAAGGAGGAACTGCAGGACAGGCTGGTA
GTGGTGCTGTGCAACCTGAAACCCCAGAAGATGAGAGGAGTCGAGTCCCAAGGCATGCTT
CTGTGTGCTTCTATAGAAGGGATAAACCGCCAGGTTGAACCTCTGGACCCTCCGGCAGGC
TCTGCTCCTGGTGAGCACGTGTTTGTGAAGGGCTATGAAAAGGGCCAACCAGATGAGGAG
CTCAAGCCCAAGAAGAAAGTCTTCGAGAAGTTGCAGGCTGACTTCAAAATTTCTGAGGAG
TGCATCGCACAGTGGAAGCAAACCAACTTCATGACCAAGCTGGGCTCCATTTCCTGTAAA
TCGCTGAAAGGGGGGAACATTAGCTAG
|
| GenBank Gene ID |
U40714 |
| GeneCard ID |
YARS |
| GenAtlas ID |
YARS |
| HGNC ID |
HGNC:12840 |
| HPRD ID |
09153 |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
1p35.1 |
| SNPs |
YARS |
| General References |
- Ribas de Pouplana L, Frugier M, Quinn CL, Schimmel P: Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):166-70. Pubmed
- Kleeman TA, Wei D, Simpson KL, First EA: Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine. J Biol Chem. 1997 May 30;272(22):14420-5. Pubmed
- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. Epub 2003 Mar 31. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB08617 |
4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE |
small molecule |
experimental |
| 2 |
DB01766 |
Beta-(2-Naphthyl)-Alanine |
small molecule |
experimental |
| 3 |
DB00135 |
L-Tyrosine |
small molecule |
approved, nutraceutical |
| 4 |
DB07205 |
N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE |
small molecule |
experimental |
| 5 |
DB08371 |
PARA-(BENZOYL)-PHENYLALANINE |
small molecule |
experimental |
| 6 |
DB03978 |
Tyrosinal |
small molecule |
experimental |
|
