| ID |
281 |
| Name |
5'-AMP-activated protein kinase subunit beta-1 |
| Synonyms |
|
| Gene Name |
PRKAB1 |
| Protein Sequence |
>5'-AMP-activated protein kinase subunit beta-1
GNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFL
AWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEG
EHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSS
SPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYA
LSIKDGVMVLSATHRYKKKYVTTLLYKPI
|
| Number of Residues |
269 |
| Molecular Weight |
30251 |
| Theoretical pI |
6.37 |
| GO Classification |
| Function |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on glycosyl bonds |
| hydrolase activity, hydrolyzing O-glycosyl compounds |
| Process |
| physiological process |
| metabolism |
| macromolecule metabolism |
| carbohydrate metabolism |
|
| General Function |
Involved in hydrolase activity, hydrolyzing O-glycosyl compounds |
| Specific Function |
AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone- sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adaptor molecule for the catalytic alpha-subunit |
| Pathways |
Not Available |
| Reactions |
Not Available |
| Pfam Domain Function |
|
| Signals |
None |
| Transmembrane Regions |
None |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
2916800  |
| UniProtKB ID |
Q9Y478 |
| UniProtKB Entry Name |
AAKB1_HUMAN |
| PDB ID |
Not Available |
| Cellular Location |
Cytoplasmic |
| Gene Sequence |
>813 bp
ATGGGCAATACCAGCAGTGAGAGGGCGGCGCTGGAGCGGCATGCTGGCCATAAGACGCCC
CGGAGGGACAGCTCGGGGGGCACCAAGGACGGGGACAGGCCCAAGATCCTGATGGACAGC
CCCGAAGACGCCGACCTCTTCCACTCCGAGGAAATCAAGGCACCAGAGAAGGAGGAATTC
CTGGCCTGGCAGCATGATCTGGAAGTGAATGATAAAGCTCCCGCCCAGGCTCGGCCAACG
GTGTTTCGATGGACGGGGGGCGGAAAGGAAGTTTACTTATCTGGGTCCTTCAACAACTGG
AGTAAACTTCCCCTCACCAGAAGCCACAATAACTTTGTAGCCATCCTGGATCTGCCGGAA
GGAGAGCATCAGTACAAGTTCTTTGTGGATGGTCAGTGGACGCACGACCCTTCCGAGCCC
ATAGTAACCAGCCAGCTTGGCACAGTTAACAACATAATTCAAGTGAAGAAAACTGACTTT
GAGGTATTTGATGCTTTAATGGTGGATTCCCAAAAGTGCTCCGATGTGTCTGAGCTGTCC
AGTTCTCCCCCAGGACCCTACCATCAGGAGCCCTACGTCTGCAAACCCGAAGAGCGCTTT
CGGGCACCCCCTATTCTCCCCCCACATCTCCTCCAGGTCATCCTGAACAAGGACACGGGG
ATTTCCTGTGATCCAGCTTTGCTTCCTGAGCCCAATCACGTCATGCTGAACCACCTATAC
GCGCTGTCTATCAAGGATGGAGTGATGGTGCTCAGCGCAACCCACCGGTACAAGAAGAAG
TACGTCACCACCTTGTTATACAAGCCCATATGA
|
| GenBank Gene ID |
AJ224515 |
| GeneCard ID |
PRKAB1 |
| GenAtlas ID |
PRKAB1 |
| HGNC ID |
HGNC:9378 |
| HPRD ID |
04116 |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
12q24.1 |
| SNPs |
PRKAB1 |
| General References |
- Stapleton D, Woollatt E, Mitchelhill KI, Nicholl JK, Fernandez CS, Michell BJ, Witters LA, Power DA, Sutherland GR, Kemp BE: AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location. FEBS Lett. 1997 Jun 16;409(3):452-6. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB00131 |
Adenosine monophosphate |
small molecule |
approved, nutraceutical |
| 2 |
DB00331 |
Metformin |
small molecule |
approved |
|
