| ID |
2831 |
| Name |
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| Synonyms |
|
| Gene Name |
Not Available |
| Protein Sequence |
>3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
MNDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLD
VTIEEDWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVDINLTGVFIGMK
TVIPAMKDAGGGSIVNISSAAGLMGLALTSSYGASKWGVRGLSKLAAVELGTDRIRVNSV
HPGMTYTPMTAETGIRQGEGNYPNTPMGRVGNEPGEIAGAVVKLLSDTSSYVTGAELAVD
GGWTTGPTVKYVMGQ
|
| Number of Residues |
255 |
| Molecular Weight |
26484 |
| Theoretical pI |
4.71 |
| GO Classification |
| Function |
| catalytic activity |
| oxidoreductase activity |
| Process |
| physiological process |
| metabolism |
|
| General Function |
Lipid transport and metabolism |
| Specific Function |
Androstan-3-alpha,17-beta-diol + NAD(+) = 17- beta-hydroxyandrostan-3-one + NADH |
| Pathways |
Not Available |
| Reactions |
- androstan-3alpha,17beta-diol + NAD+ = 17beta-hydroxyandrostan-3-one + NADH + H+
|
| Pfam Domain Function |
|
| Signals |
None |
| Transmembrane Regions |
None |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
Not Available |
| UniProtKB ID |
P19992  |
| UniProtKB Entry Name |
HSD_STREX |
| PDB ID |
2HSD |
| PDB File |
show |
| 3D Structure |
View 3D Structure |
| Cellular Location |
Not Available |
| Gene Sequence |
Not Available
|
| GenBank Gene ID |
Not Available |
| GeneCard ID |
Not Available |
| GenAtlas ID |
Not Available |
| HGNC ID |
Not Available |
| HPRD ID |
Not Available |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
Not Available |
| SNPs |
Not Available |
| General References |
- Marekov L, Krook M, Jornvall H: Prokaryotic 20 beta-hydroxysteroid dehydrogenase is an enzyme of the ‘short-chain, non-metalloenzyme’ alcohol dehydrogenase type. FEBS Lett. 1990 Jun 18;266(1-2):51-4. Pubmed
- Ghosh D, Weeks CM, Grochulski P, Duax WL, Erman M, Rimsay RL, Orr JC: Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10064-8. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB02329 |
Carbenoxolone |
small molecule |
experimental |
| 2 |
DB01907 |
Nicotinamide-Adenine-Dinucleotide |
small molecule |
experimental |
|
