| ID |
2907 |
| Name |
Oxysterols receptor LXR-beta |
| Synonyms |
- Liver X receptor beta
- Nuclear orphan receptor LXR-beta
- Ubiquitously-expressed nuclear receptor
- Nuclear receptor NER
|
| Gene Name |
NR1H2 |
| Protein Sequence |
>Oxysterols receptor LXR-beta
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS
QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK
RSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQ
IALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAM
RRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPR
MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
|
| Number of Residues |
461 |
| Molecular Weight |
51102 |
| Theoretical pI |
7.80 |
| GO Classification |
| Component |
| organelle |
| membrane-bound organelle |
| intracellular membrane-bound organelle |
| nucleus |
| Function |
| ligand-dependent nuclear receptor activity |
| DNA binding |
| binding |
| signal transducer activity |
| receptor activity |
| nucleic acid binding |
| steroid hormone receptor activity |
| transcription factor activity |
| Process |
| regulation of biological process |
| regulation of physiological process |
| regulation of metabolism |
| regulation of cellular metabolism |
| regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism |
| regulation of transcription |
| regulation of transcription, DNA-dependent |
|
| General Function |
Involved in transcription factor activity |
| Specific Function |
Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4) |
| Pathways |
Not Available |
| Reactions |
Not Available |
| Pfam Domain Function |
|
| Signals |
None |
| Transmembrane Regions |
None |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
641962  |
| UniProtKB ID |
P55055 |
| UniProtKB Entry Name |
NR1H2_HUMAN |
| PDB ID |
1UPW |
| PDB File |
show |
| 3D Structure |
View 3D Structure |
| Cellular Location |
Nucleus (Potential) |
| Gene Sequence |
>1386 bp
ATGTCCTCTCCTACCACGAGTTCCCTGGATACCCCCCTGCCTGGAAATGGCCCCCCTCAG
CCTGGCGCCCCTTCTTCTTCACCCACTGTAAAGGAGGAGGGTCCGGAGCCGTGGCCCGGG
GGTCCGGACCCTGATGTCCCAGGCACTGATGAGGCCAGCTCAGCCTGCAGCACAGACTGG
GTCATCCCAGATCCCGAAGAGGAACCAGAGCGCAAGCGAAAGAAGGGCCCAGCCCCGAAG
ATGCTGGGCCACGAGCTTTGCCGTGTCTGTGGGGACAAGGCCTCCGGCTTCCACTACAAC
GTGCTCAGCTGCGAAGGCTGCAAGGGCTTCTTCCGGCGCAGTGTGGTCCGTGGTGGGGCC
AGGCGCTATGCCTGCCGGGGTGGCGGAACCTGCCAGATGGACGCTTTCATGCGGCGCAAG
TGCCAGCAGTGCCGGCTGCGCAAGTGCAAGGAGGCAGGGATGAGGGAGCAGTGCGTCCTT
TCTGAAGAACAGATCCGGAAGAAGAAGATTCGGAAACAGCAGCAGCAGGAGTCACAGTCA
CAGTCGCAGTCACCTGTGGGGCCGCAGGGCAGCAGCAGCTCAGCCTCTGGGCCTGGGGCT
TCCCCTGGTGGATCTGAGGCAGGCAGCCAGGGCTCCGGGGAAGGCGAGGGTGTCCAGCTA
ACAGCGGCTCAAGAACTAATGATCCAGCAGTTGGTGGCGGCCCAACTGCAGTGCAACAAA
CGCTCCTTCTCCGACCAGCCCAAAGTCACGCCCTGGCCCCTGGGCGCAGACCCCCAGTCC
CGAGATGCCCGCCAGCAACGCTTTGCCCACTTCACGGAGCTGGCCATCATCTCAGTCCAG
GAGATCGTGGACTTCGCTAAGCAAGTGCCTGGTTTCCTGCAGCTGGGCCGGGAGGACCAG
ATCGCCCTCCTGAAGGCATCCACTATCGAGATCATGCTGCTAGAGACAGCCAGGCGCTAC
AACCACGAGACAGAGTGTATCACCTTCTTGAAGGACTTCACCTACAGCAAGGACGACTTC
CACCGTGCAGGCCTGCAGGTGGAGTTCATCAACCCCATCTTCGAGTTCTCGCGGGCCATG
CGGCGGCTGGGCCTGGACGACGCTGAGTACGCCCTGCTCATCGCCATCAACATCTTCTCG
GCCGACCGGCCCAACGTGCAGGAGCCGGGCCGCGTGGAGGCGTTGCAGCAGCCCTACGTG
GAGGCGCTGCTGTCCTACACGCGCATCAAGAGGCCGCAGGACCAGCTGCGCTTCCCGCGC
ATGCTCATGAAGCTGGTGAGCCTGCGCACGCTGAGCTCTGTGCACTCGGAGCAGGTCTTC
GCCTTGCGGCTCCAGGACAAGAAGCTGCCGCCTCTGCTGTCGGAGATCTGGGACGTCCAC
GAGTGA
|
| GenBank Gene ID |
U07132 |
| GeneCard ID |
NR1H2 |
| GenAtlas ID |
NR1H2 |
| HGNC ID |
HGNC:7965 |
| HPRD ID |
02660 |
| IUPHAR ID |
601 |
| Guide to Pharmacology ID |
89 |
| Chromosome Location |
Not Available |
| Locus |
19q13.3-19q13.3 |
| SNPs |
NR1H2 |
| General References |
- Shinar DM, Endo N, Rutledge SJ, Vogel R, Rodan GA, Schmidt A: NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. Gene. 1994 Sep 30;147(2):273-6. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB03791 |
(3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic Acid |
small molecule |
experimental |
| 2 |
DB07082 |
1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL |
small molecule |
experimental |
| 3 |
DB03848 |
Benzenesulfonyl |
small molecule |
experimental |
| 4 |
DB07080 |
N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE |
small molecule |
experimental |
|
