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Enoyl-[acyl-carrier-protein] reductase [NADH]

ID 3228
Name Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms
  • EC 1.3.1.9
  • NADH- dependent enoyl-ACP reductase
Gene Name fabI
Protein Sequence 
>Enoyl-[acyl-carrier-protein] reductase [NADH]
MGFLKGKKGLIVGVANNKSIAYGIAQSCFNQGATLAFTYLNESLEKRVRPIAQELNSPYV
YELDVSKEEHFKSLYNSVKKDLGSLDFIVHSVAFAPKEALEGSLLETSKSAFNTAMEISV
YSLIELTNTLKPLLNNGASVLTLSYLGSTKYMAHYNVMGLAKAALESAVRYLAVDLGKHH
IRVNALSAGPIRTLASSGIADFRMILKWNEINAPLRKNVSLEEVGNAGMYLLSSLSSGVS
GEVHFVDAGYHVMGMGAVEEKDNKATLLWDLHKEQ
Number of Residues 275
Molecular Weight 29982
Theoretical pI 7.80
GO Classification
Function
catalytic activity
oxidoreductase activity
Process
physiological process
metabolism
General Function Lipid transport and metabolism
Specific Function Acyl-[acyl-carrier-protein] + NAD(+) = trans- 2,3-dehydroacyl-[acyl-carrier-protein] + NADH
Pathways Not Available
Reactions
  • acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH + H+
Pfam Domain Function Not Available
Signals None
Transmembrane Regions None
Essentiality Non-Essential
GenBank Protein ID 2313282 Link_out
UniProtKB ID O24990 Link_out
UniProtKB Entry Name FABI_HELPY Link_out
PDB ID 1JVF Link_out
PDB File show
3D Structure View 3D Structure
Cellular Location Cell inner membrane; peripheral membrane protein
Gene Sequence 
>828 bp
ATGGGATTTTTAAAAGGTAAAAAAGGGCTTATTGTAGGGGTGGCGAACAATAAATCCATC
GCTTATGGGATCGCTCAATCTTGTTTCAATCAAGGGGCTACTTTGGCTTTCACTTATTTG
AATGAGAGTTTAGAAAAGCGCGTAAGGCCTATCGCGCAGGAATTGAATAGCCCCTATGTG
TATGAATTGGATGTGAGCAAAGAAGAGCATTTCAAGTCGCTATACAATAGCGTTAAAAAG
GATTTAGGCTCATTGGATTTTATTGTTCATAGCGTGGCCTTTGCCCCTAAAGAGGCTTTA
GAGGGGAGCTTGTTGGAAACTTCTAAAAGCGCGTTTAACACCGCTATGGAAATTTCTGTT
TATTCTTTAATAGAGCTGACAAACACCCTAAAACCTTTATTGAATAACGGAGCGTCTGTT
TTGACTCTAAGCTATTTGGGTAGCACCAAATACATGGCGCATTACAATGTGATGGGGTTG
GCTAAAGCGGCCCTAGAGAGTGCGGTGCGTTATTTAGCGGTGGATTTAGGCAAACACCAT
ATAAGAGTGAATGCCCTATCGGCCGGGCCTATTAGGACGCTCGCTTCTAGCGGGATCGCT
GATTTTAGAATGATTTTAAAATGGAATGAAATCAACGCCCCTTTAAGAAAAAATGTGAGT
TTAGAAGAAGTGGGCAATGCCGGGATGTATTTGCTCTCTAGTTTGTCTAGCGGGGTGAGT
GGGGAAGTGCATTTTGTGGATGCTGGCTATCATGTTATGGGCATGGGGGCTGTGGAAGAA
AAAGATAATAAAGCTACGCTACTGTGGGATTTGCATAAAGAACAATAA
GenBank Gene ID AE000511 Link_out
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
HPRD ID Not Available
IUPHAR ID Not Available
Guide to Pharmacology ID Not Available
Chromosome Location Not Available
Locus Not Available
SNPs fabI Link_out
General References
  1. Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC: The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997 Aug 7;388(6642):539-47. Pubmed
Drugs
# DrugBank ID Drug Name Drug Type Drug Groups
1 DB04393 Diclosan small molecule experimental
2 DB01907 Nicotinamide-Adenine-Dinucleotide small molecule experimental
3 DB08604 TRICLOSAN small molecule experimental