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Fatty acid-binding protein, brain

ID 3312
Name Fatty acid-binding protein, brain
Synonyms
  • B-FABP
  • Brain lipid-binding protein
  • BLBP
  • Mammary-derived growth inhibitor related
Gene Name FABP7
Protein Sequence
>Fatty acid-binding protein, brain
MVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKVVIRTLSTFKN
TEISFQLGEEFDETTADDRNCKSVVSLDGDKLVHIQKWDGKETNFVREIKDGKMVMTLTF
GDVVAVRHYEKA
Number of Residues 132
Molecular Weight 14889
Theoretical pI 5.25
GO Classification
Function
binding
lipid binding
Process
physiological process
cellular physiological process
transport
General Function Involved in fatty acid binding
Specific Function B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers
Pathways Not Available
Reactions Not Available
Pfam Domain Function
Signals None
Transmembrane Regions None
Essentiality Non-Essential
GenBank Protein ID 2632065 Link_out
UniProtKB ID O15540 Link_out
UniProtKB Entry Name FABP7_HUMAN Link_out
PDB ID 1FE3 Link_out
PDB File show
3D Structure View 3D Structure
Cellular Location Cytoplasm
Gene Sequence
>399 bp
ATGGTGGAGGCTTTCTGTGCTACCTGGAAGCTGACCAACAGTCAGAACTTTGATGAGTAC
ATGAAGGCTCTAGGCGTGGGCTTTGCCACTAGGCAGGTGGGAAATGTGACCAAACCAACG
GTAATTATCAGTCAAGAAGGAGACAAAGTGGTCATCAGGACTCTCAGCACATTCAAGAAC
ACGGAGATTAGTTTCCAGCTGGGAGAAGAGTTTGATGAAACCACTGCAGATGATAGAAAC
TGTAAGTCTGTTGTTAGCCTGGATGGAGACAAACTTGTTCACATACAGAAATGGGATGGC
AAAGAAACAAATTTTGTAAGAGAAATTAAGGATGGCAAAATGGTTATGACCCTTACTTTT
GGTGATGTGGTTGCTGTTCGCCACTATGAGAAGGCATAA
GenBank Gene ID AJ002962 Link_out
GeneCard ID FABP7 Link_out
GenAtlas ID FABP7 Link_out
HGNC ID HGNC:3562 Link_out
HPRD ID 04271
IUPHAR ID Not Available
Guide to Pharmacology ID Not Available
Chromosome Location Not Available
Locus 6q22-q23
SNPs FABP7 Link_out
General References
  1. Shimizu F, Watanabe TK, Shinomiya H, Nakamura Y, Fujiwara T: Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP). Biochim Biophys Acta. 1997 Oct 9;1354(1):24-8. Pubmed
  2. Godbout R, Bisgrove DA, Shkolny D, Day RS 3rd: Correlation of B-FABP and GFAP expression in malignant glioma. Oncogene. 1998 Apr 16;16(15):1955-62. Pubmed
  3. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. Pubmed
  4. Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC: Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. J Biol Chem. 2000 Sep 1;275(35):27045-54. Pubmed
  5. Rademacher M, Zimmerman AW, Ruterjans H, Veerkamp JH, Lucke C: Solution structure of fatty acid-binding protein from human brain. Mol Cell Biochem. 2002 Oct;239(1-2):61-8. Pubmed
Drugs
# DrugBank ID Drug Name Drug Type Drug Groups
1 DB00132 Alpha-Linolenic Acid small molecule approved, nutraceutical
2 DB03756 Docosa-4,7,10,13,16,19-Hexaenoic Acid small molecule experimental
3 DB00154 gamma-Homolinolenic acid small molecule approved, nutraceutical
4 DB00159 Icosapent small molecule approved, nutraceutical
5 DB04224 Oleic Acid small molecule experimental