| ID |
3817 |
| Name |
Complement C1q subcomponent subunit C |
| Synonyms |
- Complement C1q subcomponent subunit C precursor
|
| Gene Name |
C1QC |
| Protein Sequence |
>Complement C1q subcomponent subunit C
MDVGPSSLPHLGLKLLLLLLLLPLRGQANTGCYGIPGMPGLPGAPGKDGYDGLPGPKGEP
GIPAIPGIRGPKGQKGEPGLPGHPGKNGPMGPPGMPGVPGPMGIPGEPGEEGRYKQKFQS
VFTVTRQTHQPPAPNSLIRFNAVLTNPQGDYDTSTGKFTCKVPGLYYFVYHASHTANLCV
LLYRSGVKVVTFCGHTSKTNQVNSGGVLLRLQVGEEVWLAVNDYYDMVGIQGSDSVFSGF
LLFPD
|
| Number of Residues |
245 |
| Molecular Weight |
25774 |
| Theoretical pI |
8.58 |
| GO Classification |
| Component |
| cell |
| intracellular |
| cytoplasm |
| Process |
| physiological process |
| cellular physiological process |
| transport |
| ion transport |
| anion transport |
| inorganic anion transport |
| phosphate transport |
|
| General Function |
Not Available |
| Specific Function |
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes |
| Pathways |
Not Available |
| Reactions |
Not Available |
| Pfam Domain Function |
|
| Signals |
1-28 |
| Transmembrane Regions |
None |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
33150626  |
| UniProtKB ID |
P02747 |
| UniProtKB Entry Name |
C1QC_HUMAN |
| PDB ID |
1PK6 |
| PDB File |
show |
| 3D Structure |
View 3D Structure |
| Cellular Location |
Secreted protein |
| Gene Sequence |
>738 bp
ATGGACGTGGGGCCCAGCTCCCTGCCCCACCTTGGGCTGAAGCTGCTGCTGCTCCTGCTG
CTGCTGCCCCTCAGGGCCAAAGCCAACACAGGCTGCTACGGGATCCCAGGGATGCCCGGC
CTGCCCGGGGCACCAGGGAAGGATGGGTACGACGGACTGCCGGGGCCCAAGGGGGAGCCA
GGAATCCCAGCCATTCCCGGGATCCGAGGACCCAAAGGGCAGAAGGGAGAACCCGGCTTA
CCCGGCCATCCTGGGAAAAATGGCCCCATGGGACCCCCTGGGATGCCAGGGGTGCCCGGC
CCCATGGGATTCCCTGGAGAGCCAGGTGAGGAGGGCAGATACAAGCAGAAATTCCAGTCA
GTGTTCACGGTCACTCGGCAGACCCACCAGCCCCCTGCACCCAACAGCCTGATCAGATTC
AACGCGGTCCTCACCAACCCGCAGGAGGATTATGACACGAGCACTGGCAAGTTCACCTGC
AAAGTCCCCGGCCTCTACTACTTTGTCTACCACGCGTCGCATACAGCCAACCTGTGCGTG
CTGCTGTACCGCAGCGGCGTCAAAGTGGTCACCTTCTGTGGCCACACGTCCAAAACCAAT
CAGGTCAACTCGGGCGGTGTGCTGCTGAGGTTGCAGGTGGGCGAGGAGGTGTGGCTGGCT
GTCAATGACTACTACGACATGGTGGGCATCCAGGGCTCTGACAGCGTCTTCTCCGGCTTC
CTGCTCTTCCCCGACTAG
|
| GenBank Gene ID |
AF087892 |
| GeneCard ID |
C1QC |
| GenAtlas ID |
C1QC |
| HGNC ID |
HGNC:1245 |
| HPRD ID |
Not Available |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
1p36.11 |
| SNPs |
C1QC |
| General References |
- Sellar GC, Blake DJ, Reid KB: Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q. Biochem J. 1991 Mar 1;274 ( Pt 2):481-90. Pubmed
- Reid KB: Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement. Biochem J. 1979 May 1;179(2):367-71. Pubmed
- Gaboriaud C, Juanhuix J, Gruez A, Lacroix M, Darnault C, Pignol D, Verger D, Fontecilla-Camps JC, Arlaud GJ: The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties. J Biol Chem. 2003 Nov 21;278(47):46974-82. Epub 2003 Sep 5. Pubmed
- Petry F: Molecular basis of hereditary C1q deficiency. Immunobiology. 1998 Aug;199(2):286-94. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB00054 |
Abciximab |
biotech |
approved |
| 2 |
DB00051 |
Adalimumab |
biotech |
approved |
| 3 |
DB00092 |
Alefacept |
biotech |
approved, investigational |
| 4 |
DB00087 |
Alemtuzumab |
biotech |
approved, investigational |
| 5 |
DB00074 |
Basiliximab |
biotech |
approved, investigational |
| 6 |
DB00112 |
Bevacizumab |
biotech |
approved, investigational |
| 7 |
DB00002 |
Cetuximab |
biotech |
approved |
| 8 |
DB00111 |
Daclizumab |
biotech |
approved, investigational |
| 9 |
DB00095 |
Efalizumab |
biotech |
approved, investigational |
| 10 |
DB00005 |
Etanercept |
biotech |
approved, investigational |
| 11 |
DB00056 |
Gemtuzumab ozogamicin |
biotech |
approved, investigational |
| 12 |
DB00078 |
Ibritumomab |
biotech |
approved |
| 13 |
DB00075 |
Muromonab |
biotech |
approved |
| 14 |
DB00108 |
Natalizumab |
biotech |
approved, investigational |
| 15 |
DB00110 |
Palivizumab |
biotech |
approved, investigational |
| 16 |
DB00073 |
Rituximab |
biotech |
approved |
| 17 |
DB00081 |
Tositumomab |
biotech |
approved |
| 18 |
DB00072 |
Trastuzumab |
biotech |
approved, investigational |
|
