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Low affinity immunoglobulin gamma Fc region receptor II-a

ID 3819
Name Low affinity immunoglobulin gamma Fc region receptor II-a
Synonyms
  • Fc-gamma RII-a
  • FcRII-a
  • IgG Fc receptor II-a
  • Fc-gamma-RIIa
  • CD32 antigen
  • CDw32
  • Low affinity immunoglobulin gamma Fc region receptor II-a precursor
Gene Name FCGR2A
Protein Sequence 
>Low affinity immunoglobulin gamma Fc region receptor II-a
MAMETQMSQNVCPRNLWLLQPLTVLLLLASADSQAAAPPKAVLKLEPPWINVLQEDSVTL
TCQGARSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVL
SEWLVLQTPHLEFQEGETIMLRCHSWKDKPLVKVTFFQNGKSQKFSRLDPTFSIPQANHS
HSGDYHCTGNIGYTLFSSKPVTITVQVPSMGSSSPMGIIVAVVIATAVAAIVAAVVALIY
CRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQLEETNNDYETADGGYMTLNPRAPTDDD
KNIYLTLPPNDHVNSNN
Number of Residues 317
Molecular Weight 34990
Theoretical pI 6.78
GO Classification Not Available
General Function Not Available
Specific Function Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens
Pathways Not Available
Reactions Not Available
Pfam Domain Function
Signals 1-33
Transmembrane Regions 218-240
Essentiality Non-Essential
GenBank Protein ID 182474 Link_out
UniProtKB ID P12318 Link_out
UniProtKB Entry Name FCG2A_HUMAN Link_out
PDB ID 1H9V Link_out
PDB File show
3D Structure View 3D Structure
Cellular Location Membrane
Gene Sequence 
>954 bp
ATGGCTATGGAGACCCAAATGTCTCAGAATGTATGTCCCAGAAACCTGTGGCTGCTTCAA
CCATTGACAGTTTTGCTGCTGCTGGCTTCTGCAGACAGTCAAGCTGCAGCTCCCCCAAAG
GCTGTGCTGAAACTTGAGCCCCCGTGGATCAACGTGCTCCAGGAGGACTCTGTGACTCTG
ACATGCCAGGGGGCTCGCAGCCCTGAGAGCGACTCCATTCAGTGGTTCCACAATGGGAAT
CTCATTCCCACCCACACGCAGCCCAGCTACAGGTTCAAGGCCAACAACAATGACAGCGGG
GAGTACACGTGCCAGACTGGCCAGACCAGCCTCAGCGACCCTGTGCATCTGACTGTGCTT
TCCGAATGGCTGGTGCTCCAGACCCCTCACCTGGAGTTCCAGGAGGGAGAAACCATCATG
CTGAGGTGCCACAGCTGGAAGGACAAGCCTCTGGTCAAGGTCACATTCTTCCAGAATGGA
AAATCCCAGAAATTCTCCCGTTTGGATCCCACCTTCTCCATCCCACAAGCAAACCACAGT
CACAGTGGTGATTACCACTGCACAGGAAACATAGGCTACACGCTGTTCTCATCCAAGCCT
GTGACCATCACTGTCCAAGTGCCCAGCATGGGCAGCTCTTCACCAATGGGGATCATTGTG
GCTGTGGTCATTGCGACTGCTGTAGCAGCCATTGTTGCTGCTGTAGTGGCCTTGATCTAC
TGCAGGAAAAAGCGGATTTCAGCCAATTCCACTGATCCTGTGAAGGCTGCCCAATTTGAG
CCACCTGGACGTCAAATGATTGCCATCAGAAAGAGACAACTTGAAGAAACCAACAATGAC
TATGAAACAGCTGACGGCGGCTACATGACTCTGAACCCCAGGGCACCTACTGACGATGAT
AAAAACATCTACCTGACTCTTCCTCCCAACGACCATGTCAACAGTAATAACTAA
GenBank Gene ID M31932 Link_out
GeneCard ID FCGR2A Link_out
GenAtlas ID FCGR2A Link_out
HGNC ID HGNC:3616 Link_out
HPRD ID Not Available
IUPHAR ID Not Available
Guide to Pharmacology ID Not Available
Chromosome Location Not Available
Locus 1q23
SNPs FCGR2A Link_out
General References
  1. Brooks DG, Qiu WQ, Luster AD, Ravetch JV: Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J Exp Med. 1989 Oct 1;170(4):1369-85. Pubmed
  2. Stuart SG, Trounstine ML, Vaux DJ, Koch T, Martens CL, Mellman I, Moore KW: Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII). J Exp Med. 1987 Dec 1;166(6):1668-84. Pubmed
  3. Hibbs ML, Bonadonna L, Scott BM, McKenzie IF, Hogarth PM: Molecular cloning of a human immunoglobulin G Fc receptor. Proc Natl Acad Sci U S A. 1988 Apr;85(7):2240-4. Pubmed
  4. Stengelin S, Stamenkovic I, Seed B: Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning. EMBO J. 1988 Apr;7(4):1053-9. Pubmed
  5. Seki T: Identification of multiple isoforms of the low-affinity human IgG Fc receptor. Immunogenetics. 1989;30(1):5-12. Pubmed
  6. Powell MS, Barton PA, Emmanouilidis D, Wines BD, Neumann GM, Peitersz GA, Maxwell KF, Garrett TP, Hogarth PM: Biochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgG. Immunol Lett. 1999 May 3;68(1):17-23. Pubmed
  7. Maxwell KF, Powell MS, Hulett MD, Barton PA, McKenzie IF, Garrett TP, Hogarth PM: Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa. Nat Struct Biol. 1999 May;6(5):437-42. Pubmed
  8. Salmon JE, Millard S, Schachter LA, Arnett FC, Ginzler EM, Gourley MF, Ramsey-Goldman R, Peterson MG, Kimberly RP: Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. J Clin Invest. 1996 Mar 1;97(5):1348-54. Pubmed
Drugs
# DrugBank ID Drug Name Drug Type Drug Groups
1 DB00054 Abciximab biotech approved
2 DB00051 Adalimumab biotech approved
3 DB00092 Alefacept biotech approved, investigational
4 DB00087 Alemtuzumab biotech approved, investigational
5 DB00074 Basiliximab biotech approved, investigational
6 DB00112 Bevacizumab biotech approved, investigational
7 DB00002 Cetuximab biotech approved
8 DB00111 Daclizumab biotech approved, investigational
9 DB00095 Efalizumab biotech approved, investigational
10 DB00005 Etanercept biotech approved, investigational
11 DB00056 Gemtuzumab ozogamicin biotech approved, investigational
12 DB00078 Ibritumomab biotech approved
13 DB00028 Intravenous Immunoglobulin biotech approved, investigational
14 DB00075 Muromonab biotech approved
15 DB00108 Natalizumab biotech approved, investigational
16 DB00110 Palivizumab biotech approved, investigational
17 DB00073 Rituximab biotech approved
18 DB00081 Tositumomab biotech approved
19 DB00072 Trastuzumab biotech approved, investigational