| ID |
3820 |
| Name |
Low affinity immunoglobulin gamma Fc region receptor II-b |
| Synonyms |
- Fc-gamma RII-b
- FcRII-b
- IgG Fc receptor II-b
- Fc-gamma-RIIb
- CD32 antigen
- CDw32
- Low affinity immunoglobulin gamma Fc region receptor II-b precursor
|
| Gene Name |
FCGR2B |
| Protein Sequence |
>Low affinity immunoglobulin gamma Fc region receptor II-b
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWIN
VLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSL
SDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPN
FSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAA
VVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDEADKVGAENTITYSLLMHPDA
LEEPDDQNRI
|
| Number of Residues |
310 |
| Molecular Weight |
34044 |
| Theoretical pI |
6.12 |
| GO Classification |
Not Available |
| General Function |
Not Available |
| Specific Function |
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis |
| Pathways |
Not Available |
| Reactions |
Not Available |
| Pfam Domain Function |
|
| Signals |
1-42 |
| Transmembrane Regions |
218-240 |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
4099445  |
| UniProtKB ID |
P31994 |
| UniProtKB Entry Name |
FCG2B_HUMAN |
| PDB ID |
2FCB |
| PDB File |
show |
| 3D Structure |
View 3D Structure |
| Cellular Location |
Membrane |
| Gene Sequence |
>930 bp
ATGGGAATCCTGTCATTCTTACCTGTCCTTGCCACTGAGAGTGACTGGGCTGACTGCAAG
TCCCCCCAGCCTTGGGGTCATATGCTTCTGTGGACAGCTGTGCTATTCCTGGCTCCTGTT
GCTGGGACACCTGCAGCTCCCCCAAAGGCTGTGCTGAAACTCGAGCCCCAGTGGATCAAC
GTGCTCCAGGAGGACTCTGTGACTCTGACATGCCGGGGGACTCACAGCCCTGAGAGCGAC
TCCATTCAGTGGTTCCACAATGGGAATCTCATTCCCACCCACACGCAGCCCAGCTACAGG
TTCAAGGCCAACAACAATGACAGCGGGGAGTACACGTGCCAGACTGGCCAGACCAGCCTC
AGCGACCCTGTGCATCTGACTGTGCTTTCTGAGTGGCTGGTGCTCCAGACCCCTCACCTG
GAGTTCCAGGAGGGAGAAACCATCGTGCTGAGGTGCCACAGCTGGAAGGACAAGCCTCTG
GTCAAGGTCACATTCTTCCAGAATGGAAAATCCAAGAAATTTTCCCGTTCGGATCCCAAC
TTCTCCATCCCACAAGCAAACCACAGTCACAGTGGTGATTACCACTGCACAGGAAACATA
GGCTACACGCTGTACTCATCCAAGCCTGTGACCATCACTGTCCAAGCTCCCAGCTCTTCA
CCGATGGGGATCATTGTGGCTGTGGTCACTGGGATTGCTGTAGCGGCCATTGTTGCTGCT
GTAGTGGCCTTGATCTACTGCAGGAAAAAGCGGATTTCAGCTCTCCCAGGATACCCTGAG
TGCAGGGAAATGGGAGAGACCCTCCCTGAGAAACCAGCCAATCCCACTAATCCTGATGAG
GCTGACAAAGTTGGGGCTGAGAACACAATCACCTATTCACTTCTCATGCACCCGGATGCT
CTGGAAGAGCCTGATGACCAGAACCGTATT
|
| GenBank Gene ID |
U87560 |
| GeneCard ID |
FCGR2B |
| GenAtlas ID |
FCGR2B |
| HGNC ID |
HGNC:3618 |
| HPRD ID |
Not Available |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
1q23 |
| SNPs |
FCGR2B |
| General References |
- Stuart SG, Simister NE, Clarkson SB, Kacinski BM, Shapiro M, Mellman I: Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium. EMBO J. 1989 Dec 1;8(12):3657-66. Pubmed
- Brooks DG, Qiu WQ, Luster AD, Ravetch JV: Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J Exp Med. 1989 Oct 1;170(4):1369-85. Pubmed
- Engelhardt W, Geerds C, Frey J: Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II. Eur J Immunol. 1990 Jun;20(6):1367-77. Pubmed
- Kyogoku C, Dijstelbloem HM, Tsuchiya N, Hatta Y, Kato H, Yamaguchi A, Fukazawa T, Jansen MD, Hashimoto H, van de Winkel JG, Kallenberg CG, Tokunaga K: Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. Arthritis Rheum. 2002 May;46(5):1242-54. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB00054 |
Abciximab |
biotech |
approved |
| 2 |
DB00051 |
Adalimumab |
biotech |
approved |
| 3 |
DB00092 |
Alefacept |
biotech |
approved, investigational |
| 4 |
DB00087 |
Alemtuzumab |
biotech |
approved, investigational |
| 5 |
DB00098 |
Antithymocyte globulin |
biotech |
approved |
| 6 |
DB00074 |
Basiliximab |
biotech |
approved, investigational |
| 7 |
DB00112 |
Bevacizumab |
biotech |
approved, investigational |
| 8 |
DB00002 |
Cetuximab |
biotech |
approved |
| 9 |
DB00111 |
Daclizumab |
biotech |
approved, investigational |
| 10 |
DB00095 |
Efalizumab |
biotech |
approved, investigational |
| 11 |
DB00005 |
Etanercept |
biotech |
approved, investigational |
| 12 |
DB00056 |
Gemtuzumab ozogamicin |
biotech |
approved, investigational |
| 13 |
DB00078 |
Ibritumomab |
biotech |
approved |
| 14 |
DB00028 |
Intravenous Immunoglobulin |
biotech |
approved, investigational |
| 15 |
DB00075 |
Muromonab |
biotech |
approved |
| 16 |
DB00108 |
Natalizumab |
biotech |
approved, investigational |
| 17 |
DB00110 |
Palivizumab |
biotech |
approved, investigational |
| 18 |
DB00073 |
Rituximab |
biotech |
approved |
| 19 |
DB00081 |
Tositumomab |
biotech |
approved |
| 20 |
DB00072 |
Trastuzumab |
biotech |
approved, investigational |
|
