| ID |
3821 |
| Name |
Low affinity immunoglobulin gamma Fc region receptor II-c |
| Synonyms |
- Fc-gamma RII-c
- FcRII-c
- IgG Fc receptor II-c
- Fc-gamma-RIIc
- CD32 antigen
- CDw32
- Low affinity immunoglobulin gamma Fc region receptor II-c precursor
|
| Gene Name |
FCGR2C |
| Protein Sequence |
>Low affinity immunoglobulin gamma Fc region receptor II-c
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWIN
VLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSL
SDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPN
FSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAA
VVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQPEETNNDYETADGGYMTLNPR
APTDDDKNIYLTLPPNDHVNSNN
|
| Number of Residues |
323 |
| Molecular Weight |
35578 |
| Theoretical pI |
6.90 |
| GO Classification |
Not Available |
| General Function |
Not Available |
| Specific Function |
Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells |
| Pathways |
Not Available |
| Reactions |
Not Available |
| Pfam Domain Function |
|
| Signals |
1-42 |
| Transmembrane Regions |
224-246 |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
32074  |
| UniProtKB ID |
P31995 |
| UniProtKB Entry Name |
FCG2C_HUMAN |
| PDB ID |
2FCB |
| PDB File |
show |
| 3D Structure |
View 3D Structure |
| Cellular Location |
Cell membrane |
| Gene Sequence |
>972 bp
ATGGGAATCCTGTCATTTTTACCTGTCCTTGCCACTGAGAGTGACTGGGCTGACTGCAAG
TCCCCCCAGCCTTGGGGTCATATGCTTCTGTGGACAGCTGTGCTATTCCTGGCTCCTGTT
GCTGGGACACCTGCAGCTCCCCCAAAGGCTGTGCTGAAACTCGAGCCCCAGTGGATCAAC
GTGCTCCAGGAGGACTCTGTGACTCTGACATGCCGGGGGACTCACAGCCCTGAGAGCGAC
TCCATTCAGTGGTTCCACAATGGGAATCTCATTCCCACCCACACGCAGCCCAGCTACAGG
TTCAAGGCCAACAACAATGACAGCGGGGAGTACACGTGCCAGACTGGCCAGACCAGCCTC
AGCGACCCTGTGCATCTGACAGTGCTTTCTGAGTGGCTGGTGCTCCAGACCCCTCACCTG
GAGTTCCAGGAGGGAGAAACCATCGTGCTGAGGTGCCACAGCTGGAAGGACAAGCCTCTG
GTCAAGGTCACATTCTTCCAGAATGGAAAATCCAAGAAATTTTCCCGTTCGGATCCCAAC
TTCTCCATCCCACAAGCAAACCACAGTCACAGTGGTGATTACCATTGCACAGGAAACATA
GGCTACACGCTGTACTCATCCAAGCCTGTGACCATCACTGTCCAAGCTCCCAGCTCTTCA
CCGATGGGGATCATTGTGGCTGTGGTCACTGGGATTGCTGTAGCTGCCATTGTTGCTGCT
GTAGTGGCCTTGATCTACTGCAGGAAAAAGCGGATTTCAGCCAATTCCACTGATCCTGTG
AAGGCTGCCCAATTTGAGCCACCTGGACGTCAAATGATTGCCATCAGAAAGAGACAACCT
GAAGAAACCAACAATGACTATGAAACAGCTGACGGCGGCTACATGACTCTGAACCCCAGG
GCACCTACTGACGATGATAAAAACATCTACTTGACTCTTCCTCCCAACGACCATGTCAAC
AGTAATAACTAA
|
| GenBank Gene ID |
X17652 |
| GeneCard ID |
FCGR2C |
| GenAtlas ID |
FCGR2C |
| HGNC ID |
HGNC:15626 |
| HPRD ID |
Not Available |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
1q23.3 |
| SNPs |
FCGR2C |
| General References |
- Stuart SG, Simister NE, Clarkson SB, Kacinski BM, Shapiro M, Mellman I: Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium. EMBO J. 1989 Dec 1;8(12):3657-66. Pubmed
- Metes D, Ernst LK, Chambers WH, Sulica A, Herberman RB, Morel PA: Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene. Blood. 1998 Apr 1;91(7):2369-80. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB00054 |
Abciximab |
biotech |
approved |
| 2 |
DB00051 |
Adalimumab |
biotech |
approved |
| 3 |
DB00092 |
Alefacept |
biotech |
approved, investigational |
| 4 |
DB00087 |
Alemtuzumab |
biotech |
approved, investigational |
| 5 |
DB00074 |
Basiliximab |
biotech |
approved, investigational |
| 6 |
DB00112 |
Bevacizumab |
biotech |
approved, investigational |
| 7 |
DB00002 |
Cetuximab |
biotech |
approved |
| 8 |
DB00111 |
Daclizumab |
biotech |
approved, investigational |
| 9 |
DB00095 |
Efalizumab |
biotech |
approved, investigational |
| 10 |
DB00005 |
Etanercept |
biotech |
approved, investigational |
| 11 |
DB00056 |
Gemtuzumab ozogamicin |
biotech |
approved, investigational |
| 12 |
DB00078 |
Ibritumomab |
biotech |
approved |
| 13 |
DB00028 |
Intravenous Immunoglobulin |
biotech |
approved, investigational |
| 14 |
DB00075 |
Muromonab |
biotech |
approved |
| 15 |
DB00108 |
Natalizumab |
biotech |
approved, investigational |
| 16 |
DB00110 |
Palivizumab |
biotech |
approved, investigational |
| 17 |
DB00073 |
Rituximab |
biotech |
approved |
| 18 |
DB00081 |
Tositumomab |
biotech |
approved |
| 19 |
DB00072 |
Trastuzumab |
biotech |
approved, investigational |
|
