| ID |
3923 |
| Name |
Cholinesterase |
| Synonyms |
- EC 3.1.1.8
- Acylcholine acylhydrolase
- Choline esterase II
- Butyrylcholine esterase
- Pseudocholinesterase
- Cholinesterase precursor
|
| Gene Name |
BCHE |
| Protein Sequence |
>Cholinesterase
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
|
| Number of Residues |
602 |
| Molecular Weight |
68419 |
| Theoretical pI |
7.47 |
| GO Classification |
| Function |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on ester bonds |
| carboxylic ester hydrolase activity |
| cholinesterase activity |
|
| General Function |
Lipid transport and metabolism |
| Specific Function |
An acylcholine + H(2)O = choline + a carboxylate |
| Pathways |
|
| Reactions |
- an acylcholine + H2O = choline + a carboxylate
|
| Pfam Domain Function |
|
| Signals |
1-28 |
| Transmembrane Regions |
None |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
1311630  |
| UniProtKB ID |
P06276 |
| UniProtKB Entry Name |
CHLE_HUMAN |
| PDB ID |
1P0Q |
| PDB File |
show |
| 3D Structure |
View 3D Structure |
| Cellular Location |
Cytoplasmic |
| Gene Sequence |
>1809 bp
ATGCATAGCAAAGTCACAATCATATGCATCAGATTTCTCTTTTGGTTTCTTTTGCTCTGC
ATGCTTATTGGGAAGTCACATACTGAAGATGACATCATAATTGCAACAAAGAATGGAAAA
GTCAGAGGGATGAACTTGACAGTTTTTGGTGGCACGGTAACAGCCTTTCTTGGAATTCCC
TATGCACAGCCACCTCTTGGTAGACTTCGATTCAAAAAGCCACAGTCTCTGACCAAGTGG
TCTGATATTTGGAATGCCACAAAATATGCAAATTCTTGCTGTCAGAACATAGATCAAAGT
TTTCCAGGCTTCCATGGATCAGAGATGTGGAACCCAAACACTGACCTCAGTGAAGACTGT
TTATATCTAAATGTATGGATTCCAGCACCTAAACCAAAAAATGCCACTGTATTGATATGG
ATTTATGGTGGTGGTTTTCAAACTGGAACATCATCTTTACATGTTTATGATGGCAAGTTT
CTGGCTCGGGTTGAAAGAGTTATTGTAGTGTCAATGAACTATAGGGTGGGTGCCCTAGGA
TTCTTAGCTTTGCCAGGAAATCCTGAGGCTCCAGGGAACATGGGTTTATTTGATCAACAG
TTGGCTCTTCAGTGGGTTCAAAAAAATATAGCAGCCTTTGGTGGAAATCCTAAAAGTGTA
ACTCTCTTTGGAGAAAGTGCAGGAGCAGCTTCAGTTAGCCTGCATTTGCTTTCTCCTGGA
AGCCATTCATTGTTCACCAGAGCCATTCTGCAAAGTGGATCCTTTAATGCTCCTTGGGCG
GTAACATCTCTTTATGAAGCTAGGAACAGAACGTTGAACTTAGCTAAATTGACTGGTTGC
TCTAGAGAGAATGAGACTGAAATAATCAAGTGTCTTAGAAATAAAGATCCCCAAGAAATT
CTTCTGAATGAAGCATTTGTTGTCCCCTATGGGACTCCTTTGTCAGTAAACTTTGGTCCG
ACCGTGGATGGTGATTTTCTCACTGACATGCCAGACATATTACTTGAACTTGGACAATTT
AAAAAAACCCAGATTTTGGTGGGTGTTAATAAAGATGAAGGGACAGCTTTTTTAGTCTAT
GGTGCTCCTGGCTTCAGCAAAGATAACAATAGTATCATAACTAGAAAAGAATTTCAGGAA
GGTTTAAAAATATTTTTTCCAGGAGTGAGTGAGTTTGGAAAGGAATCCATCCTTTTTCAT
TACACAGACTGGGTAGATGATCAGAGACCTGAAAACTACCGTGAGGCCTTGGGTGATGTT
GTTGGGGATTATAATTTCATATGCCCTGCCTTGGAGTTCACCAAGAAGTTCTCAGAATGG
GGAAATAATGCCTTTTTCTACTATTTTGAACACCGATCCTCCAAACTTCCGTGGCCAGAA
TGGATGGGAGTGATGCATGGCTATGAAATTGAATTTGTCTTTGGTTTACCTCTGGAAAGA
AGAGATAATTACACAAAAGCCGAGGAAATTTTGAGTAGATCCATAGTGAAACGTTGGGCA
AATTTTGCAAAATATGGGAATCCAAATGAGACTCAGAACAATAGCACAAGCTGGCCTGTC
TTCAAAAGCACTGAACAAAAATATCTAACCTTGAATACAGAGTCAACAAGAATAATGACG
AAACTACGTGCTCAACAATGTCGATTCTGGACATCATTTTTTCCAAAAGTCTTGGAAATG
ACAGGAAATATTGATGAAGCAGAATGGGAGTGGAAAGCAGGATTCCATCGCTGGAACAAT
TACATGATGGACTGGAAAAATCAATTTAACGATTACACTAGCAAGAAAGAAAGTTGTGTG
GGTCTCTAA
|
| GenBank Gene ID |
M32391 |
| GeneCard ID |
BCHE |
| GenAtlas ID |
BCHE |
| HGNC ID |
HGNC:983 |
| HPRD ID |
01519 |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
3q26.1-q26.2 |
| SNPs |
BCHE |
| General References |
- Arpagaus M, Kott M, Vatsis KP, Bartels CF, La Du BN, Lockridge O: Structure of the gene for human butyrylcholinesterase. Evidence for a single copy. Biochemistry. 1990 Jan 9;29(1):124-31. Pubmed
- Prody CA, Zevin-Sonkin D, Gnatt A, Goldberg O, Soreq H: Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues. Proc Natl Acad Sci U S A. 1987 Jun;84(11):3555-9. Pubmed
- McTiernan C, Adkins S, Chatonnet A, Vaughan TA, Bartels CF, Kott M, Rosenberry TL, La Du BN, Lockridge O: Brain cDNA clone for human cholinesterase. Proc Natl Acad Sci U S A. 1987 Oct;84(19):6682-6. Pubmed
- Lockridge O, Bartels CF, Vaughan TA, Wong CK, Norton SE, Johnson LL: Complete amino acid sequence of human serum cholinesterase. J Biol Chem. 1987 Jan 15;262(2):549-57. Pubmed
- Lockridge O, Adkins S, La Du BN: Location of disulfide bonds within the sequence of human serum cholinesterase. J Biol Chem. 1987 Sep 25;262(27):12945-52. Pubmed
- Lockridge O: Structure of human serum cholinesterase. Bioessays. 1988 Oct;9(4):125-8. Pubmed
- McGuire MC, Nogueira CP, Bartels CF, Lightstone H, Hajra A, Van der Spek AF, Lockridge O, La Du BN: Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase. Proc Natl Acad Sci U S A. 1989 Feb;86(3):953-7. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB08200 |
(1R)-MENTHYL HEXYL PHOSPHONATE GROUP |
small molecule |
experimental |
| 2 |
DB08201 |
(1S)-MENTHYL HEXYL PHOSPHONATE GROUP |
small molecule |
experimental |
| 3 |
DB03814 |
2-(N-Morpholino)-Ethanesulfonic Acid |
small molecule |
experimental |
| 4 |
DB07940 |
9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE |
small molecule |
experimental |
| 5 |
DB03672 |
9-N-Phenylmethylamino-Tacrine |
small molecule |
experimental |
| 6 |
DB02944 |
Alpha-D-Mannose |
small molecule |
experimental |
| 7 |
DB01122 |
Ambenonium |
small molecule |
approved |
| 8 |
DB01408 |
Bambuterol |
small molecule |
approved |
| 9 |
DB02687 |
Beta-D-Mannose |
small molecule |
experimental |
| 10 |
DB03568 |
Butanoic Acid |
small molecule |
experimental |
| 11 |
DB04250 |
Butyrylthiocholine |
small molecule |
experimental |
| 12 |
DB01161 |
Chloroprocaine |
small molecule |
approved |
| 13 |
DB00856 |
Chlorphenesin |
small molecule |
approved |
| 14 |
DB00477 |
Chlorpromazine |
small molecule |
approved |
| 15 |
DB00122 |
Choline |
small molecule |
approved, nutraceutical |
| 16 |
DB00515 |
Cisplatin |
small molecule |
approved |
| 17 |
DB04920 |
Clevidipine |
small molecule |
approved |
| 18 |
DB00979 |
Cyclopentolate |
small molecule |
approved |
| 19 |
DB01245 |
Decamethonium |
small molecule |
approved |
| 20 |
DB00944 |
Demecarium |
small molecule |
approved |
| 21 |
DB00527 |
Dibucaine |
small molecule |
approved |
| 22 |
DB00711 |
Diethylcarbamazine |
small molecule |
approved |
| 23 |
DB02811 |
Diethylphosphono Group |
small molecule |
experimental |
| 24 |
DB00449 |
Dipivefrin |
small molecule |
approved |
| 25 |
DB07681 |
DODECANESULFONATE ION |
small molecule |
experimental |
| 26 |
DB01135 |
Doxacurium chloride |
small molecule |
approved |
| 27 |
DB01395 |
Drospirenone |
small molecule |
approved |
| 28 |
DB01525 |
Ecgonine |
small molecule |
illicit, experimental |
| 29 |
DB01057 |
Echothiophate |
small molecule |
approved |
| 30 |
DB01010 |
Edrophonium |
small molecule |
approved |
| 31 |
DB01364 |
Ephedrine |
small molecule |
approved |
| 32 |
DB00392 |
Ethopropazine |
small molecule |
approved |
| 33 |
DB03822 |
Ethyl Dihydrogen Phosphate |
small molecule |
experimental |
| 34 |
DB08658 |
ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATE |
small molecule |
experimental |
| 35 |
DB00674 |
Galantamine |
small molecule |
approved |
| 36 |
DB00941 |
Hexafluronium |
small molecule |
approved |
| 37 |
DB00677 |
Isoflurophate |
small molecule |
approved |
| 38 |
DB00772 |
Malathion |
small molecule |
approved, investigational |
| 39 |
DB00358 |
Mefloquine |
small molecule |
approved |
| 40 |
DB02845 |
Methylphosphinic Acid |
small molecule |
experimental |
| 41 |
DB01226 |
Mivacurium |
small molecule |
approved |
| 42 |
DB04251 |
Monoisopropyl Ester Phosphonic Acid Group |
small molecule |
experimental |
| 43 |
DB01400 |
Neostigmine |
small molecule |
approved |
| 44 |
DB00585 |
Nizatidine |
small molecule |
approved |
| 45 |
DB00892 |
Oxybuprocaine |
small molecule |
approved |
| 46 |
DB01337 |
Pancuronium |
small molecule |
approved |
| 47 |
DB00082 |
Pegvisomant |
biotech |
approved |
| 48 |
DB00183 |
Pentagastrin |
small molecule |
approved |
| 49 |
DB00790 |
Perindopril |
small molecule |
approved |
| 50 |
DB01338 |
Pipecuronium |
small molecule |
approved |
| 51 |
DB00733 |
Pralidoxime |
small molecule |
approved |
| 52 |
DB01035 |
Procainamide |
small molecule |
approved |
| 53 |
DB00721 |
Procaine |
small molecule |
approved, investigational |
| 54 |
DB00545 |
Pyridostigmine |
small molecule |
approved |
| 55 |
DB00178 |
Ramipril |
small molecule |
approved |
| 56 |
DB00989 |
Rivastigmine |
small molecule |
approved, investigational |
| 57 |
DB00202 |
Succinylcholine |
small molecule |
approved |
| 58 |
DB00391 |
Sulpiride |
small molecule |
approved |
| 59 |
DB00382 |
Tacrine |
small molecule |
approved |
| 60 |
DB00871 |
Terbutaline |
small molecule |
approved |
| 61 |
DB00620 |
Triamcinolone |
small molecule |
approved |
| 62 |
DB00508 |
Triflupromazine |
small molecule |
approved |
| 63 |
DB01116 |
Trimethaphan |
small molecule |
approved |
|
