| ID |
428 |
| Name |
Interferon-alpha/beta receptor beta chain |
| Synonyms |
- IFN-alpha-REC
- Type I interferon receptor
- IFN-R
- Interferon alpha/beta receptor 2
- Interferon-alpha/beta receptor beta chain precursor
|
| Gene Name |
IFNAR2 |
| Protein Sequence |
>Interferon-alpha/beta receptor beta chain precursor
MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS
IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF
SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK
HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE
SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD
MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI
DPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGR
ITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPT
FPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR
|
| Number of Residues |
515 |
| Molecular Weight |
57759 |
| Theoretical pI |
4.11 |
| GO Classification |
Not Available |
| General Function |
Involved in interferon-alpha/beta receptor activity |
| Specific Function |
Receptor for interferons alpha and beta. Isoform 1 and isoform 3 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity |
| Pathways |
Not Available |
| Reactions |
Not Available |
| Pfam Domain Function |
Not Available |
| Signals |
1-26 |
| Transmembrane Regions |
244-264 |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
995300  |
| UniProtKB ID |
P48551 |
| UniProtKB Entry Name |
INAR2_HUMAN |
| PDB ID |
1N6V |
| PDB File |
show |
| 3D Structure |
View 3D Structure |
| Cellular Location |
Membrane; single-pass type I membrane protein |
| Gene Sequence |
>1548 bp
ATGCTTTTGAGCCAGAATGCCTTCATCTTCAGATCACTTAATTTGGTTCTCATGGTGTAT
ATCAGCCTCGTGTTTGGTATTTCATATGATTCGCCTGATTACACAGATGAATCTTGCACT
TTCAAGATATCATTGCGAAATTTCCGGTCCATCTTATCATGGGAATTAAAAAACCACTCC
ATTGTACCAACTCACTATACATTGCTGTATACAATCATGAGTAAACCAGAAGATTTGAAG
GTGGTTAAGAACTGTGCAAATACCACAAGATCATTTTGTGACCTCACAGATGAGTGGAGA
AGCACACACGAGGCCTATGTCACCGTCCTAGAAGGATTCAGCGGGAACACAACGTTGTTC
AGTTGCTCACACAATTTCTGGCTGGCCATAGACATGTCTTTTGAACCACCAGAGTTTGAG
ATTGTTGGTTTTACCAACCACATTAATGTGATGGTGAAATTTCCATCTATTGTTGAGGAA
GAATTACAGTTTGATTTATCTCTCGTCATTGAAGAACAGTCAGAGGGAATTGTTAAGAAG
CATAAACCCGAAATAAAAGGAAACATGAGTGGAAATTTCACCTATATCATTGACAAGTTA
ATTCCAAACACGAACTACTGTGTATCTGTTTATTTAGAGCACAGTGATGAGCAAGCAGTA
ATAAAGTCTCCCTTAAAATGCACCCTCCTTCCACCTGGCCAGGAATCAGAATCAGCAGAA
TCTGCCAAAATAGGAGGAATAATTACTGTGTTTTTGATAGCATTGGTCTTGACAAGCACC
ATAGTGACACTGAAATGGATTGGTTATATATGCTTAAGAAATAGCCTCCCCAAAGTCTTG
AATTTTCATAACTTTTTAGCCTGGCCATTTCCTAACCTGCCACCGTTGGAAGCCATGGAT
ATGGTGGAGGTCATTTACATCAACAGAAAGAAGAAAGTGTGGGATTATAATTATGATGAT
GAAAGTGATAGCGATACTGAGGCAGCGCCCAGGACAAGTGGCGGTGGCTATACCATGCAT
GGACTGACTGTCAGGCCTCTGGGTCAGGCCTCTGCCACCTCTACAGAATCCCAGTTGATA
GACCCGGAGTCCGAGGAGGAGCCTGACCTGCCTGAGGTTGATGTGGAGCTCCCCACGATG
CCAAAGGACAGCCCTCAGCAGTTGGAACTCTTGAGTGGGCCCTGTGAGAGGAGAAAGAGT
CCACTCCAGGACCCTTTTCCCGAAGAGGACTACAGCTCCACGGAGGGGTCTGGGGGCAGA
ATTACCTTCAATGTGGACTTAAACTCTGTGTTTTTGAGAGTTCTTGATGACGAGGACAGT
GACGACTTAGAAGCCCCTCTGATGCTATCGTCTCATCTGGAAGAGATGGTTGACCCAGAG
GATCCTGATAATGTGCAATCAAACCATTTGCTGGCCAGCGGGGAAGGGACACAGCCAACC
TTTCCCAGCCCCTCTTCAGAGGGCCTGTGGTCCGAAGATGCTCCATCTGATCAAAGTGAC
ACTTCTGAGTCAGATGTTGACCTTGGGGATGGTTATATAATGAGATGA
|
| GenBank Gene ID |
L42243 |
| GeneCard ID |
IFNAR2 |
| GenAtlas ID |
IFNAR2 |
| HGNC ID |
HGNC:5433 |
| HPRD ID |
03850 |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
Not Available |
| SNPs |
IFNAR2 |
| General References |
- Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE, et al.: Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J. 1995 Oct 16;14(20):5100-8. Pubmed
- Novick D, Cohen B, Rubinstein M: The human interferon alpha/beta receptor: characterization and molecular cloning. Cell. 1994 May 6;77(3):391-400. Pubmed
- Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR: Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. J Biol Chem. 1995 Sep 15;270(37):21606-11. Pubmed
- Novick D, Cohen B, Tal N, Rubinstein M: Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor. J Leukoc Biol. 1995 May;57(5):712-8. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB00034 |
Interferon Alfa-2a, Recombinant |
biotech |
approved |
| 2 |
DB00105 |
Interferon Alfa-2b, Recombinant |
biotech |
approved |
| 3 |
DB00011 |
Interferon alfa-n1 |
biotech |
approved |
| 4 |
DB00018 |
Interferon alfa-n3 |
biotech |
approved, investigational |
| 5 |
DB00069 |
Interferon alfacon-1 |
biotech |
approved |
| 6 |
DB00060 |
Interferon beta-1a |
biotech |
approved, investigational |
| 7 |
DB00068 |
Interferon beta-1b |
biotech |
approved |
| 8 |
DB00008 |
Peginterferon alfa-2a |
biotech |
approved, investigational |
| 9 |
DB00022 |
Peginterferon alfa-2b |
biotech |
approved |
|
