Banner

A/G-specific adenine glycosylase

ID 4692
Name A/G-specific adenine glycosylase
Synonyms
  • EC 3.2.2.-
Gene Name mutY
Protein Sequence 
>A/G-specific adenine glycosylase
MQASQFSAQVLDWYDKYGRKTLPWQIDKTPYKVWLSEVMLQQTQVATVIPYFERFMARFP
TVTDLANAPLDEVLHLWTGLGYYARARNLHKAAQQVATLHGGKFPETFEEVAALPGVGRS
TAGAILSLSLGKHFPILDGNVKRVLARCYAVSGWPGKKEVENKLWSLSEQVTPAVGVERF
NQAMMDLGAMICTRSKPKCSLCPLQNGCIAAANNSWALYPGKKPKQTLPERTGYFLLLQH
EDEVLLAQRPPSGLWGGLYCFPQFADEESLRQWLAQRQIAADNLTQLTAFRHTFSHFHLD
IVPMWLPVSSFTGCMDEGNALWYNLAQPPSVGLAAPVERLLQQLRTGAPV
Number of Residues 350
Molecular Weight 39149
Theoretical pI 8.46
GO Classification
Component
cell
intracellular
Function
ion binding
DNA binding
cation binding
transition metal ion binding
iron ion binding
nuclease activity
endonuclease activity
hydrolase activity, hydrolyzing N-glycosyl compounds
hydrolase activity
DNA N-glycosylase activity
nucleic acid binding
binding
hydrolase activity, acting on glycosyl bonds
catalytic activity
hydrolase activity, acting on ester bonds
Process
DNA metabolism
DNA repair
metabolism
cellular metabolism
base-excision repair
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
physiological process
General Function Involved in catalytic activity
Specific Function Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past go lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine
Pathways Not Available
Reactions Not Available
Pfam Domain Function
Signals None
Transmembrane Regions None
Essentiality Non-Essential
GenBank Protein ID Not Available
UniProtKB ID P17802 Link_out
UniProtKB Entry Name MUTY_ECOLI Link_out
PDB ID 1KG3 Link_out
PDB File show
3D Structure View 3D Structure
Cellular Location Cytoplasmic
Gene Sequence 
>1053 bp
ATGCAAGCGTCGCAATTTTCAGCCCAGGTTCTGGACTGGTACGATAAATACGGGCGAAAA
ACTCTGCCCTGGCAAATTGACAAGACGCCCTACAAAGTATGGCTCTCAGAAGTGATGTTG
CAACAAACTCAGGTTGCGACCGTTATCCCCTATTTTGAACGCTTTATGGCGCGCTTCCCG
ACGGTGACCGATCTCGCCAATGCGCCGCTCGACGAAGTTCTCCACTTGTGGACCGGGCTT
GGCTATTACGCCCGCGCGCGCAATCTGCATAAAGCGGCACAACAAGTGGCGACCTTACAC
GGCGGTAAATTCCCGGAAACCTTTGAGGAAGTTGCAGCACTGCCGGGCGTCGGGCGTTCC
ACCGCAGGCGCGATTCTCTCGCTTTCTCTGGGTAAGCACTTTCCGATTCTCGACGGTAAC
GTCAAACGCGTGCTGGCGCGCTGCTATGCTGTAAGCGGCTGGCCTGGGAAAAAAGAGGTC
GAGAATAAATTATGGAGTTTGAGCGAGCAGGTGACGCCCGCGGTTGGCGTGGAACGGTTT
AATCAGGCGATGATGGATTTGGGTGCGATGATTTGTACGCGCTCGAAACCGAAATGTTCG
CTCTGTCCGCTACAAAACGGATGTATTGCCGCCGCCAACAATAGCTGGGCGCTTTATCCG
GGCAAAAAACCGAAACAGACGCTGCCGGAGCGCACCGGCTACTTTTTGCTATTACAGCAC
GAAGATGAAGTATTGCTGGCGCAGCGTCCGCCGAGCGGATTGTGGGGCGGTTTATACTGT
TTCCCGCAGTTTGCCGACGAAGAAAGTTTGCGGCAGTGGCTGGCGCAACGGCAGATTGCT
GCCGATAACCTGACGCAACTGACCGCGTTTCGGCATACCTTCAGCCATTTCCACTTAGAT
ATTGTGCCTATGTGGCTTCCCGTGTCGTCATTCACCGGCTGCATGGATGAAGGCAATGCG
CTCTGGTATAACTTAGCGCAACCGCCGTCAGTTGGCCTAGCGGCTCCCGTGGAGCGTTTG
TTACAGCAGTTACGCACTGGCGCGCCGGTTTAG
GenBank Gene ID X52391 Link_out
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
HPRD ID Not Available
IUPHAR ID Not Available
Guide to Pharmacology ID Not Available
Chromosome Location Not Available
Locus Not Available
SNPs mutY Link_out
General References
  1. Michaels ML, Pham L, Nghiem Y, Cruz C, Miller JH: MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III. Nucleic Acids Res. 1990 Jul 11;18(13):3841-5. Pubmed
  2. Tsai-Wu JJ, Radicella JP, Lu AL: Nucleotide sequence of the Escherichia coli micA gene required for A/G-specific mismatch repair: identity of micA and mutY. J Bacteriol. 1991 Mar;173(6):1902-10. Pubmed
  3. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-74. Pubmed
  4. Guan Y, Manuel RC, Arvai AS, Parikh SS, Mol CD, Miller JH, Lloyd S, Tainer JA: MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily. Nat Struct Biol. 1998 Dec;5(12):1058-64. Pubmed
Drugs
# DrugBank ID Drug Name Drug Type Drug Groups
1 DB00173 Adenine small molecule approved, nutraceutical
2 DB02379 Beta-D-Glucose small molecule experimental
3 DB04077 Glycerol small molecule experimental