Histamine H1 receptor

492

Name

Histamine H1 receptor

Synonyms

Not Available

Gene Name

HRH1

Protein Sequence

>Histamine H1 receptor
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS

Number of Residues

487

Molecular Weight

55785

Theoretical pI

9.58

GO Classification

Component
cell
intrinsic to membrane
integral to membrane
membrane
Function
amine receptor activity
histamine receptor activity
signal transducer activity
receptor activity
transmembrane receptor activity
G-protein coupled receptor activity
rhodopsin-like receptor activity
Process
cell communication
signal transduction
cell surface receptor linked signal transduction
G-protein coupled receptor protein signaling pathway
cellular process

General Function

Involved in rhodopsin-like receptor activity

Specific Function

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system

Pathways

Not Available

Reactions

Not Available

Pfam Domain Function

7tm_1 (PF00001 )

Signals

None

Transmembrane Regions

30-49 64-83 102-123 146-165 190-210 419-438 451-470

Essentiality

Non-Essential

GenBank Protein ID

510296

UniProtKB ID

P35367

UniProtKB Entry Name

HRH1_HUMAN Link_out

PDB ID

Not Available

Cellular Location

Membrane; multi-pass membrane protein

Gene Sequence

>1464 bp
ATGAGCCTCCCCAATTCCTCCTGCCTCTTAGAAGACAAGATGTGTGAGGGCAACAAGACC
ACTATGGCCAGCCCCCAGCTGATGCCCCTGGTGGTGGTCCTGAGCACTATCTGCTTGGTC
ACAGTAGGGCTCAACCTGCTGGTGCTGTATGCCGTACGGAGTGAGCGGAAGCTCCACACT
GTGGGGAACCTGTACATCGTCAGCCTCTCGGTGGCGGACTTGATCGTGGGTGCCGTCGTC
ATGCCTATGAACATCCTCTACCTGCTCATGTCCAAGTGGTCACTGGGCCGTCCTCTCTGC
CTCTTTTGGCTTTCCATGGACTATGTGGCCAGCACAGCGTCCATTTTCAGTGTCTTCATC
CTGTGCATTGATCGCTACCGCTCTGTCCAGCAGCCCCTCAGGTACCTTAAGTATCGTACC
AAGACCCGAGCCTCGGCCACCATTCTGGGGGCCTGGTTTCTCTCTTTTCTGTGGGTTATT
CCCATTCTAGGCTGGAATCACTTCATGCAGCAGACCTCGGTGCGCCGAGAGGACAAGTGT
GAGACAGACTTCTATGATGTCACCTGGTTCAAGGTCATGACTGCCATCATCAACTTCTAC
CTGCCCACCTTGCTCATGCTCTGGTTCTATGCCAAGATCTACAAGGCCGTACGACAACAC
TGCCAGCACCGGGAGCTCATCAATAGGTCCCTCCCTTCCTTCTCAGAAATTAAGCTGAGG
CCAGAGAACCCCAAGGGGGATGCCAAGAAACCAGGGAAGGAGTCTCCCTGGGAGGTTCTG
AAAAGGAAGCCAAAAGATGCTGGTGGTGGATCTGTCTTGAAGTCACCATCCCAAACCCCC
AAGGAGATGAAATCCCCAGTTGTCTTCAGCCAAGAGGATGATAGAGAAGTAGACAAACTC
TACTGCTTTCCACTTGATATTGTGCACATGCAGGCTGCGGCAGAGGGGAGTAGCAGGGAC
TATGTAGCCGTCAACCGGAGCCATGGCCAGCTCAAGACAGATGAGCAGGGCCTGAACACA
CATGGGGCCAGCGAGATATCAGAGGATCAGATGTTAGGTGATAGCCAATCCTTCTCTCGA
ACGGACTCAGATACCACCACAGAGACAGCACCAGGCAAAGGCAAATTGAGGAGTGGGTCT
AACACAGGCCTGGATTACATCAAGTTTACTTGGAAGAGGCTCCGCTCGCATTCAAGACAG
TATGTATCTGGGTTGCACATGAACCGCGAAAGGAAGGCCGCCAAACAGTTGGGTTTTATC
ATGGCAGCCTTCATCCTCTGCTGGATCCCTTATTTCATCTTCTTCATGGTCATTGCCTTC
TGCAAGAACTGTTGCAATGAACATTTGCACATGTTCACCATCTGGCTGGGCTACATCAAC
TCCACACTGAACCCCCTCATCTACCCCTTGTGCAATGAGAACTTCAAGAAGACATTCAAG
AGAATTCTGCATATTCGCTCCTAA

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

HPRD ID

02544

IUPHAR ID

262

Guide to Pharmacology ID

Chromosome Location

Not Available

Locus

3p25

SNPs

HRH1

General References

De Backer MD, Gommeren W, Moereels H, Nobels G, Van Gompel P, Leysen JE, Luyten WH: Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor. Biochem Biophys Res Commun. 1993 Dec 30;197(3):1601-8. Pubmed
Fukui H, Fujimoto K, Mizuguchi H, Sakamoto K, Horio Y, Takai S, Yamada K, Ito S: Molecular cloning of the human histamine H1 receptor gene. Biochem Biophys Res Commun. 1994 Jun 15;201(2):894-901. Pubmed

Drugs

#	DrugBank ID	Drug Name	Drug Type	Drug Groups
1	DB01615	Aceprometazine	small molecule	approved
2	DB06766	Alcaftadine	small molecule	approved
3	DB00321	Amitriptyline	small molecule	approved
4	DB08799	Antazoline	small molecule	approved
5	DB01238	Aripiprazole	small molecule	approved, investigational
6	DB06216	Asenapine	small molecule	approved
7	DB00637	Astemizole	small molecule	approved, withdrawn
8	DB00719	Azatadine	small molecule	approved
9	DB00972	Azelastine	small molecule	approved
10	DB00245	Benzatropine	small molecule	approved
11	DB00767	Benzquinamide	small molecule	approved
12	DB04890	Bepotastine	small molecule	approved
13	DB06698	Betahistine	small molecule	approved
14	DB01237	Bromodiphenhydramine	small molecule	approved
15	DB00835	Brompheniramine	small molecule	approved
16	DB00354	Buclizine	small molecule	approved
17	DB00748	Carbinoxamine	small molecule	approved
18	DB00341	Cetirizine	small molecule	approved
19	DB04837	Chlophedianol	small molecule	approved
20	DB08800	Chloropyramine	small molecule	approved
21	DB01114	Chlorpheniramine	small molecule	approved
22	DB00477	Chlorpromazine	small molecule	approved
23	DB01239	Chlorprothixene	small molecule	approved
24	DB00568	Cinnarizine	small molecule	approved
25	DB00283	Clemastine	small molecule	approved
26	DB00363	Clozapine	small molecule	approved
27	DB01176	Cyclizine	small molecule	approved
28	DB00434	Cyproheptadine	small molecule	approved
29	DB01151	Desipramine	small molecule	approved
30	DB00967	Desloratadine	small molecule	approved, investigational
31	DB00405	Dexbrompheniramine	small molecule	approved
32	DB00985	Dimenhydrinate	small molecule	approved
33	DB08801	Dimethindene	small molecule	approved
34	DB01075	Diphenhydramine	small molecule	approved
35	DB01146	Diphenylpyraline	small molecule	approved
36	DB01142	Doxepin	small molecule	approved
37	DB00366	Doxylamine	small molecule	approved
38	DB01084	Emedastine	small molecule	approved
39	DB00751	Epinastine	small molecule	approved, investigational
40	DB01175	Escitalopram	small molecule	approved, investigational
41	DB00950	Fexofenadine	small molecule	approved
42	DB04841	Flunarizine	small molecule	approved
43	DB00667	Histamine Phosphate	small molecule	approved
44	DB00557	Hydroxyzine	small molecule	approved
45	DB00458	Imipramine	small molecule	approved
46	DB08802	Isothipendyl	small molecule	approved
47	DB00920	Ketotifen	small molecule	approved
48	DB01106	Levocabastine	small molecule	approved
49	DB00455	Loratadine	small molecule	approved
50	DB00934	Maprotiline	small molecule	approved
51	DB00737	Meclizine	small molecule	approved
52	DB06691	Mepyramine	small molecule	approved
53	DB01071	Mequitazine	small molecule	approved
54	DB00902	Methdilazine	small molecule	approved
55	DB01403	Methotrimeprazine	small molecule	approved
56	DB06148	Mianserin	small molecule	approved
57	DB00370	Mirtazapine	small molecule	approved
58	DB00540	Nortriptyline	small molecule	approved
59	DB00334	Olanzapine	small molecule	approved, investigational
60	DB00768	Olopatadine	small molecule	approved
61	DB01173	Orphenadrine	small molecule	approved
62	DB01267	Paliperidone	small molecule	approved
63	DB01619	Phenindamine	small molecule	approved
64	DB01620	Pheniramine	small molecule	approved
65	DB00420	Promazine	small molecule	approved
66	DB01069	Promethazine	small molecule	approved
67	DB00777	Propiomazine	small molecule	approved
68	DB01224	Quetiapine	small molecule	approved
69	DB00734	Risperidone	small molecule	approved, investigational
70	DB00342	Terfenadine	small molecule	approved, withdrawn
71	DB00797	Tolazoline	small molecule	approved
72	DB00656	Trazodone	small molecule	approved, investigational
73	DB01246	Trimeprazine	small molecule	approved
74	DB00726	Trimipramine	small molecule	approved
75	DB00792	Tripelennamine	small molecule	approved
76	DB00427	Triprolidine	small molecule	approved
77	DB00246	Ziprasidone	small molecule	approved