| ID |
6764 |
| Name |
Fatty acid oxidation complex subunit alpha |
| Synonyms |
- Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase
- 3-hydroxyacyl-CoA dehydrogenase
|
| Gene Name |
fadB |
| Protein Sequence |
>Fatty acid oxidation complex subunit alpha
MIYEGKAITVTALESGIVELKFDLKGESVNKFNRLTLNELRQAVDAIKADASVKGVIVSS
GKDVFIVGADITEFVENFKLPDAELIAGNLEANKIFSDFEDLNVPTVAAINGIALGGGLE
MCLAADFRVMADSAKIGLPEVKLGIYPGFGGTVRLPRLIGVDNAVEWIASGKENRAEDAL
KVSAVDAVVTADKLGAAALDLIKRAISGELDYKAKRQPKLEKLKLNAIEQMMAFETAKGF
VAGQAGPNYPAPVEAIKTIQKAANFGRDKALEVEAAGFAKLAKTSASNCLIGLFLNDQEL
KKKAKVYDKIAKDVKQAAVLGAGIMGGGIAYQSASKGTPILMKDINEHGIEQGLAEAAKL
LVGRVDKGRMTPAKMAEVLNGIRPTLSYGDFGNVDLVVEAVVENPKVKQAVLAEVENHVR
EDAILASNTSTISISLLAKALKRPENFVGMHFFNPVHMMPLVEVIRGEKSSDLAVATTVA
YAKKMGKNPIVVNDCPGFLVNRVLFPYFGGFAKLVSAGVDFVRIDKVMEKFGWPMGPAYL
MDVVGIDTGHHGRDVMAEGFPDRMKDDRRSAIDALYEAKRLGQKNGKGFYAYEADKKGKQ
KKLVDSSVLEVLKPIVYEQRDVTDEDIINWMMIPLCLETVRCLEDGIVETAAEADMGLVY
GIGFPLFRGGALRYIDSIGVAEFVALADQYAELGALYHPTAKLREMAKNGQSFFG
|
| Number of Residues |
715 |
| Molecular Weight |
77136.7 |
| Theoretical pI |
6.05 |
| GO Classification |
| Function |
| oxidoreductase activity, acting on the CH-NH group of donors |
| oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor |
| catalytic activity |
| oxidoreductase activity |
| Process |
| carboxylic acid metabolism |
| fatty acid metabolism |
| physiological process |
| metabolism |
| cellular metabolism |
| organic acid metabolism |
|
| General Function |
Lipid transport and metabolism |
| Specific Function |
Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) |
| Pathways |
Not Available |
| Reactions |
Not Available |
| Pfam Domain Function |
|
| Signals |
None |
| Transmembrane Regions |
None |
| Essentiality |
Essential |
| GenBank Protein ID |
391839  |
| UniProtKB ID |
P28793 |
| UniProtKB Entry Name |
FADB_PSEFR |
| PDB ID |
1WDM |
| PDB File |
show |
| 3D Structure |
View 3D Structure |
| Cellular Location |
Not Available |
| Gene Sequence |
>2148 bp
ATGATTTACGAAGGTAAAGCCATCACGGTTACGGCTCTTGAAAGTGGCATCGTCGAACTG
AAGTTCGACCTCAAGGGTGAGTCCGTCAACAAATTCAACCGTCTAACCCTGAACGAATTG
CGTCAGGCGGTAGATGCGATCAAGGCCGACGCTTCGGTCAAGGGTGTCATCGTTTCCAGC
GGTAAAGACGTATTTATCGTCGGCGCCGACATCACCGAATTCGTCGAAAACTTCAAGTTG
CCGGATGCCGAGCTGATTGCTGGCAACCTCGAAGCCAACAAGATCTTCAGCGATTTTGAA
GACCTCAATGTACCCACCGTCGCAGCCATCAATGGCATCGCGTTGGGCGGTGGCCTGGAA
ATGTGCCTGGCAGCCGACTTCCGGGTCATGGCCGACAGCGCCAAGATCGGCCTGCCGGAA
GTCAAACTGGGCATCTACCCGGGCTTTGGCGGCACCGTACGTCTGCCACGCCTGATCGGT
GTTGATAACGCGGTTGAGTGGATTGCCTCCGGCAAGGAAAACCGCGCAGAAGACGCTCTG
AAAGTCAGCGCCGTTGATGCTGTTGTCACTGCTGACAAGCTGGGCGCAGCTGCCCTGGAC
CTGATCAAGCGCGCCATCAGTGGCGAACTGGACTACAAGGCCAAGCGTCAGCCGAAGCTG
GAAAAACTCAAGCTCAACGCTATCGAACAAATGATGGCTTTCGAAACCGCCAAAGGTTTC
GTGGCTGGCCAGGCCGGCCCGAACTACCCGGCCCCGGTTGAAGCGATCAAGACCATCCAG
AAAGCCGCGAACTTCGGTCGTGACAAAGCCCTGGAAGTGGAAGCTGCAGGTTTCGCCAAG
CTGGCCAAAACCAGCGCCTCGAACTGCCTGATCGGCCTGTTCCTGAACGATCAGGAACTG
AAGAAAAAGGCCAAGGTCTACGACAAGATCGCCAAAGACGTGAAGCAGGCCGCCGTTCTG
GGCGCCGGCATCATGGGTGGCGGCATTGCCTATCAGTCGGCGTCCAAAGGCACGCCGATC
CTGATGAAGGACATCAACGAGCACGGTATCGAGCAGGGCCTGGCTGAAGCCGCCAAGCTG
CTGGTAGGTCGCGTTGATAAAGGTCGCATGACCCCGGCAAAAATGGCTGAAGTGCTGAAC
GGCATTCGTCCTACTCTGTCCTACGGCGATTTCGGCAACGTCGACCTGGTGGTCGAAGCG
GTTGTCGAGAACCCGAAGGTCAAGCAGGCCGTGTTGGCGGAAGTGGAAAACCACGTTCGC
GAAGACGCCATCCTCGCTTCCAACACCTCGACCATTTCCATCAGCTTGCTGGCCAAGGCC
CTCAAGCGTCCGGAAAACTTCGTCGGCATGCACTTCTTCAACCCGGTACACATGATGCCG
CTGGTTGAAGTGATCCGTGGCGAGAAGTCCAGCGACCTGGCCGTGGCCACCACCGTTGCC
TACGCCAAGAAAATGGGCAAGAACCCGATCGTGGTCAACGACTGCCCGGGCTTCCTGGTC
AACCGCGTACTGTTCCCGTACTTCGGCGGTTTCGCCAAGCTGGTCAGCGCCGGTGTCGAC
TTTGTGCGTATCGACAAAGTGATGGAAAAATTCGGCTGGCCGATGGGCCCGGCGTACCTG
ATGGACGTGGTCGGTATCGACACTGGCCACCACGGTCGCGACGTGATGGCTGAAGGCTTC
CCGGACCGCATGAAAGACGACCGCCGCTCGGCGATCGATGCGCTGTACGAGGCCAAGCGC
CTGGGTCAGAAGAACGGCAAGGGCTTCTACGCCTACGAGGCTGACAAAAAGGGCAAGCAG
AAGAAACTGGTTGATTCGAGCGTGCTTGAAGTGCTCAAACCAATCGTTTACGAGCAGCGC
GACGTGACCGACGAAGACATCATCAACTGGATGATGATCCCGCTGTGCCTGGAAACCGTG
CGTTGCCTGGAAGACGGTATCGTTGAAACTGCAGCCGAGGCCGATATGGGCCTGGTCTAC
GGCATTGGCTTCCCGCTGTTCCGTGGTGGCGCGCTGCGCTACATCGATTCGATCGGTGTT
GCAGAGTTCGTCGCCCTGGCCGATCAGTACGCTGAACTGGGCGCGCTGTACCACCCGACT
GCGAAGCTGCGTGAGATGGCCAAGAACGGCCAGAGCTTCTTCGGTTAA
|
| GenBank Gene ID |
D10390 |
| GeneCard ID |
fadB |
| GenAtlas ID |
Not Available |
| HGNC ID |
Not Available |
| HPRD ID |
Not Available |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
Not Available |
| SNPs |
fadB |
| General References |
- Sato S, Hayashi M, Imamura S, Ozeki Y, Kawaguchi A: Primary structures of the genes, faoA and faoB, from Pseudomonas fragi B-0771 which encode the two subunits of the HDT multienzyme complex involved in fatty acid beta-oxidation. J Biochem. 1992 Jan;111(1):8-15. Pubmed
- Sato S, Ozeki Y, Kawaguchi A: Transcription of the faoAB operon which encodes the HDT multienzyme complex involved in fatty acid beta-oxidation in Pseudomonas fragi B-0771. J Biochem. 1994 Feb;115(2):286-92. Pubmed
- Ishikawa M, Tsuchiya D, Oyama T, Tsunaka Y, Morikawa K: Structural basis for channelling mechanism of a fatty acid beta-oxidation multienzyme complex. EMBO J. 2004 Jul 21;23(14):2745-54. Epub 2004 Jul 1. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB08249 |
3,6,9,12,15-PENTAOXATRICOSAN-1-OL |
small molecule |
experimental |
|
