| ID |
738 |
| Name |
Monocarboxylate transporter 1 |
| Synonyms |
- MCT 1
- Solute carrier family 16 member 1
|
| Gene Name |
SLC16A1 |
| Protein Sequence |
>Monocarboxylate transporter 1
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW
ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG
GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI
LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ
EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF
LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA
GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK
YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA
AESPDQKDTEGGPKEEESPV
|
| Number of Residues |
500 |
| Molecular Weight |
53959 |
| Theoretical pI |
8.82 |
| GO Classification |
| Component |
| cell |
| intrinsic to membrane |
| integral to membrane |
| membrane |
| Function |
| monocarboxylic acid transporter activity |
| monocarboxylate porter activity |
| transporter activity |
| organic acid transporter activity |
| carboxylic acid transporter activity |
| Process |
| physiological process |
| cellular physiological process |
| organic anion transport |
| transport |
| ion transport |
| anion transport |
|
| General Function |
Carbohydrate transport and metabolism |
| Specific Function |
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate |
| Pathways |
Not Available |
| Reactions |
Not Available |
| Pfam Domain Function |
|
| Signals |
None |
| Transmembrane Regions |
16-36
60-80
87-107
112-132
144-164
167-187
263-283
299-319
329-349
354-374
390-410
423-443 |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
561722  |
| UniProtKB ID |
P53985 |
| UniProtKB Entry Name |
MOT1_HUMAN |
| PDB ID |
Not Available |
| Cellular Location |
Cell membrane; multi-pass membrane protein |
| Gene Sequence |
>1503 bp
ATGCCACCAGCAGTTGGAGGTCCAGTTGGATACACCCCCCCAGATGGAGGCTGGGGCTGG
GCAGTGGTAATTGGAGCTTTCATTTCCATCGGCTTCTCTTATGCATTTCCCAAATCAATT
ACTGTCTTCTTCAAAGAGATTGAAGGTATATTCCATGCCACCACCAGCGAAGTGTCATGG
ATATCCTCCATAATGTTGGCTGTCATGTATGGTGGAGGTCCTATCAGCAGTATCCTGGTG
AATAAATATGGAAGTCGTATAGTCATGATTGTTGGTGGCTGCTTGTCAGGCTGTGGCTTG
ATTGCAGCTTCTTTCTGTAACACCGTACAGCAACTATACGTCTGTATTGGAGTCATTGGA
GGTCTTGGGCTTGCCTTCAACTTGAATCCAGCTCTGACCATGATTGGCAAGTATTTCTAC
AAGAGGCGACCATTGGCCAACGGACTGGCCATGGCAGGCAGCCCTGTGTTCCTCTGTACT
CTGGCCCCCCTCAATCAGGTTTTCTTCGGTATCTTTGGATGGAGAGGAAGCTTTCTAATT
CTTGGGGGCTTGCTACTAAACTGCTGTGTTGCTGGAGCCCTCATGCGACCAATCGGGCCC
AAGCCAACCAAGGCAGGGAAAGATAAGTCTAAAGCATCCCTTGAGAAAGCTGGAAAATCT
GGTGTGAAAAAAGATCTGCATGATGCAAATACAGATCTTATTGGAAGACACCCTAAACAA
GAGAAACGATCAGTCTTCCAAACAATTAATCAGTTCCTGGACTTAACCCTATTCACCCAC
AGAGGCTTTTTGCTATACCTCTCTGGAAATGTGATCATGTTTTTTGGACTCTTTGCACCT
TTGGTGTTTCTTAGTAGTTATGGGAAGAGTCAGCATTATTCTAGTGAGAAGTCTGCCTTC
CTTCTTTCCATTCTGGCTTTTGTTGACATGGTAGCCCGACCATCTATGGGACTTGTAGCC
AACACAAAGCCAATAAGACCTCGAATTCAGTATTTCTTTGCGGCTTCCGTTGTTGCAAAT
GGAGTGTGTCATATGCTAGCACCTTTATCCACTACCTATGTTGGATTCTGTGTCTATGCG
GGATTCTTTGGATTTGCCTTCGGGTGGCTCAGCTCCGTATTGTTTGAAACATTGATGGAC
CTTGTTGGACCCCAGAGGTTCTCCAGCGCTGTGGGATTGGTGACCATTGTGGAATGCTGT
CCTGTCCTCCTGGGGCCACCACTTTTAGGTCGGCTCAATGACATGTATGGAGACTACAAA
TACACATACTGGGCATGTGGCGTCGTCCTAATTATTTCAGGTATCTATCTCTTCATTGGC
ATGGGCATCAATTATCGACTTTTGGCAAAAGAACAGAAAGCAAACGAGCAGAAAAAGGAA
AGTAAAGAGGAAGAGACCAGTATAGATGTTGCTGGGAAGCCAAATGAAGTTACCAAAACA
GCAGAATCTCCGGACCAGAAAGACACAGAAGGAGGGCCCAAGGAGGAGGAAAGTCCAGTC
TGA
|
| GenBank Gene ID |
L31801 |
| GeneCard ID |
SLC16A1 |
| GenAtlas ID |
SLC16A1 |
| HGNC ID |
HGNC:10922 |
| HPRD ID |
02816 |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
1p12 |
| SNPs |
SLC16A1 |
| General References |
- Garcia CK, Li X, Luna J, Francke U: cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. Genomics. 1994 Sep 15;23(2):500-3. Pubmed
- Merezhinskaya N, Fishbein WN, Davis JI, Foellmer JW: Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport. Muscle Nerve. 2000 Jan;23(1):90-7. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB04319 |
6-Deoxyglucose |
small molecule |
experimental |
| 2 |
DB03166 |
Acetic acid |
small molecule |
approved |
| 3 |
DB01762 |
Acetoacetic Acid |
small molecule |
experimental |
| 4 |
DB04074 |
Alpha-ketoisovalerate |
small molecule |
experimental |
| 5 |
DB00345 |
Aminohippurate |
small molecule |
approved |
| 6 |
DB00415 |
Ampicillin |
small molecule |
approved |
| 7 |
DB03793 |
Benzoic Acid |
small molecule |
experimental |
| 8 |
DB03066 |
D-Lactic Acid |
small molecule |
experimental |
| 9 |
DB00529 |
Foscarnet |
small molecule |
approved |
| 10 |
DB01440 |
Gamma Hydroxybutyric Acid |
small molecule |
illicit, approved |
| 11 |
DB00142 |
L-Glutamic Acid |
small molecule |
approved, nutraceutical |
| 12 |
DB04398 |
Lactic Acid |
small molecule |
experimental |
| 13 |
DB00563 |
Methotrexate |
small molecule |
approved |
| 14 |
DB00731 |
Nateglinide |
small molecule |
approved, investigational |
| 15 |
DB00627 |
Niacin |
small molecule |
approved, nutraceutical, investigational |
| 16 |
DB04552 |
Niflumic Acid |
small molecule |
approved |
| 17 |
DB00175 |
Pravastatin |
small molecule |
approved |
| 18 |
DB01032 |
Probenecid |
small molecule |
approved |
| 19 |
DB00119 |
Pyruvic acid |
small molecule |
approved, nutraceutical |
| 20 |
DB04216 |
Quercetin |
small molecule |
experimental |
| 21 |
DB00936 |
Salicyclic acid |
small molecule |
approved |
| 22 |
DB04348 |
Taurocholic Acid |
small molecule |
experimental |
| 23 |
DB00313 |
Valproic Acid |
small molecule |
approved, investigational |
|
