| ID |
784 |
| Name |
High affinity immunoglobulin gamma Fc receptor I |
| Synonyms |
- Fc-gamma RI
- FcRI
- IgG Fc receptor I
- CD64 antigen
- High affinity immunoglobulin gamma Fc receptor I precursor
|
| Gene Name |
FCGR1A |
| Protein Sequence |
>High affinity immunoglobulin gamma Fc receptor I precursor
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG
TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPL
ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG
ISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRN
TSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVG
IMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQ
LQEGVHRKEPQGAT
|
| Number of Residues |
374 |
| Molecular Weight |
42632 |
| Theoretical pI |
8.08 |
| GO Classification |
Not Available |
| General Function |
Involved in receptor signaling protein activity |
| Specific Function |
Binds to the Fc region of immunoglobulins gamma. High affinity receptor |
| Pathways |
Not Available |
| Reactions |
Not Available |
| Pfam Domain Function |
|
| Signals |
1-15 |
| Transmembrane Regions |
293-313 |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
31332  |
| UniProtKB ID |
P12314 |
| UniProtKB Entry Name |
FCGR1_HUMAN |
| PDB ID |
Not Available |
| Cellular Location |
Membrane; single-pass type I membrane protein |
| Gene Sequence |
>1125 bp
ATGTGGTTCTTGACAACTCTGCTCCTTTGGGTTCCAGTTGATGGGCAAGTGGACACCACA
AAGGCAGTGATCTCTTTGCAGCCTCCATGGGTCAGCGTGTTCCAAGAGGAAACCGTAACC
TTGCACTGTGAGGTGCTCCATCTGCCTGGGAGCAGCTCTACACAGTGGTTTCTCAATGGC
ACAGCCACTCAGACCTCGACCCCCAGCTACAGAATCACCTCTGCCAGTGTCAATGACAGT
GGTGAATACAGGTGCCAGAGAGGTCTCTCAGGGCGAAGTGACCCCATACAGCTGGAAATC
CACAGAGGCTGGCTACTACTGCAGGTCTCCAGCAGAGTCTTCACGGAAGGAGAACCTCTG
GCCTTGAGGTGTCATGCGTGGAAGGATAAGCTGGTGTACAATGTGCTTTACTATCGAAAT
GGCAAAGCCTTTAAGTTTTTCCACTGGAATTCTAACCTCACCATTCTGAAAACCAACATA
AGTCACAATGGCACCTACCATTGCTCAGGCATGGGAAAGCATCGCTACACATCAGCAGGA
ATATCTGTCACTGTGAAAGAGCTATTTCCAGCTCCAGTGCTGAATGCATCTGTGACATCC
CCACTCCTGGAGGGGAATCTGGTCACCCTGAGCTGTGAAACAAAGTTGCTCTTGCAGAGG
CCTGGTTTGCAGCTTTACTTCTCCTTCTACATGGGCAGCAAGACCCTGCGAGGCAGGAAC
ACATCCTCTGAATACCAAATACTAACTGCTAGAAGAGAAGACTCTGGGTTATACTGGTGC
GAGGCTGCCACAGAGGATGGAAATGTCCTTAAGCGCAGCCCTGAGTTGGAGCTTCAAGTG
CTTGGCCTCCAGTTACCAACTCCTGTCTGGTTTCATGTCCTTTTCTATCTGGCAGTGGGA
ATAATGTTTTTAGTGAACACTGTTCTCTGGGTGACAATACGTAAAGAACTGAAAAGAAAG
AAAAAGTGGGATTTAGAAATCTCTTTGGATTCTGGTCATGAGAAGAAGGTAACTTCCAGC
CTTCAAGAAGACAGACATTTAGAAGAAGAGCTGAAATGTCAGGAACAAAAAGAAGAACAG
CTGCAGGAAGGGGTGCACCGGAAGGAGCCCCAGGGGGCCACGTAG
|
| GenBank Gene ID |
X14356 |
| GeneCard ID |
FCGR1A |
| GenAtlas ID |
FCGR1A |
| HGNC ID |
HGNC:3613 |
| HPRD ID |
00904 |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
1q21.2-q21.3 |
| SNPs |
FCGR1A |
| General References |
- Allen JM, Seed B: Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI). Nucleic Acids Res. 1988 Dec 23;16(24):11824. Pubmed
- Allen JM, Seed B: Isolation and expression of functional high-affinity Fc receptor complementary DNAs. Science. 1989 Jan 20;243(4889):378-81. Pubmed
- Porges AJ, Redecha PB, Doebele R, Pan LC, Salmon JE, Kimberly RP: Novel Fc gamma receptor I family gene products in human mononuclear cells. J Clin Invest. 1992 Nov;90(5):2102-9. Pubmed
- Benech PD, Sastry K, Iyer RR, Eichbaum QG, Raveh DP, Ezekowitz RA: Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure. J Exp Med. 1992 Oct 1;176(4):1115-23. Pubmed
- Ernst LK, van de Winkel JG, Chiu IM, Anderson CL: Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. J Biol Chem. 1992 Aug 5;267(22):15692-700. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB00054 |
Abciximab |
biotech |
approved |
| 2 |
DB00051 |
Adalimumab |
biotech |
approved |
| 3 |
DB00092 |
Alefacept |
biotech |
approved, investigational |
| 4 |
DB00087 |
Alemtuzumab |
biotech |
approved, investigational |
| 5 |
DB00074 |
Basiliximab |
biotech |
approved, investigational |
| 6 |
DB00112 |
Bevacizumab |
biotech |
approved, investigational |
| 7 |
DB00002 |
Cetuximab |
biotech |
approved |
| 8 |
DB00111 |
Daclizumab |
biotech |
approved, investigational |
| 9 |
DB00095 |
Efalizumab |
biotech |
approved, investigational |
| 10 |
DB00005 |
Etanercept |
biotech |
approved, investigational |
| 11 |
DB00056 |
Gemtuzumab ozogamicin |
biotech |
approved, investigational |
| 12 |
DB00078 |
Ibritumomab |
biotech |
approved |
| 13 |
DB00028 |
Intravenous Immunoglobulin |
biotech |
approved, investigational |
| 14 |
DB00992 |
Methyl aminolevulinate |
small molecule |
approved |
| 15 |
DB00075 |
Muromonab |
biotech |
approved |
| 16 |
DB00108 |
Natalizumab |
biotech |
approved, investigational |
| 17 |
DB00110 |
Palivizumab |
biotech |
approved, investigational |
| 18 |
DB00707 |
Porfimer |
small molecule |
approved, investigational |
| 19 |
DB00073 |
Rituximab |
biotech |
approved |
| 20 |
DB00081 |
Tositumomab |
biotech |
approved |
| 21 |
DB00072 |
Trastuzumab |
biotech |
approved, investigational |
|
