| ID |
851 |
| Name |
5'-AMP-activated protein kinase subunit beta-2 |
| Synonyms |
|
| Gene Name |
PRKAB2 |
| Protein Sequence |
>5'-AMP-activated protein kinase subunit beta-2
MGNTTSDRVSGERHGAKAARSEGAGGHAPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFV
SWQQDLEDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPE
GEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRD
LSSSPPGPYGQEMYAFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNH
LYALSIKDSVMVLSATHRYKKKYVTTLLYKPI
|
| Number of Residues |
272 |
| Molecular Weight |
30302 |
| Theoretical pI |
6.44 |
| GO Classification |
Not Available |
| General Function |
Involved in protein binding |
| Specific Function |
AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone- sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adapter molecule for the catalytic alpha-subunit |
| Pathways |
Not Available |
| Reactions |
Not Available |
| Pfam Domain Function |
|
| Signals |
None |
| Transmembrane Regions |
None |
| Essentiality |
Non-Essential |
| GenBank Protein ID |
2916802  |
| UniProtKB ID |
O43741 |
| UniProtKB Entry Name |
AAKB2_HUMAN |
| PDB ID |
Not Available |
| Cellular Location |
Not Available |
| Gene Sequence |
>819 bp
ATGGGAAACACCACCAGCGACCGGGTGTCCGGGGAGCGCCACGGCGCCAAGGCTGCACGC
TCCGAGGGCGCAGGCGGCCATGCCCCGGGGAAGGAGCACAAGATCATGGTGGGGAGTACG
GACGACCCCAGCGTGTTCAGCCTCCCTGACTCCAAGCTCCCTGGGGACAAAGAGTTTGTA
TCATGGCAGCAGGATTTGGAGGACTCCGTAAAGCCCACACAGCAGGCCCGGCCCACTGTT
ATCCGCTGGTCTGAAGGAGGCAAGGAGGTCTTCATCTCTGGGTCTTTCAACAATTGGAGC
ACCAAGATTCCACTGATTAAGAGCCATAATGACTTTGTTGCCATCCTGGACCTCCCTGAG
GGAGAGCACCAATACAAGTTCTTTGTGGATGGACAGTGGGTTCATGATCCATCAGAGCCT
GTGGTTACCAGTCAGCTTGGCACAATTAACAATTTGATCCATGTCAAGAAATCTGATTTT
GAGGTGTTCGATGCTTTAAAGTTAGATTCTATGGAAAGTTCTGAGACATCTTGTAGAGAC
CTTTCCAGCTCACCCCCAGGGCCTTATGGTCAAGAAATGTATGCGTTTCGATCTGAGGAA
AGATTCAAATCCCCACCCATCCTTCCTCCTCATCTACTTCAAGTTATTCTTAACAAAGAC
ACTAATATTTCTTGTGACCCAGCCTTACTCCCTGAGCCCAACCATGTTATGCTGAACCAT
CTCTATGCATTGTCCATTAAGGACAGTGTGATGGTCCTTAGCGCAACCCATCGCTACAAG
AAGAAGTATGTTACTACTCTGCTATACAAGCCCATTTGA
|
| GenBank Gene ID |
AJ224538 |
| GeneCard ID |
PRKAB2 |
| GenAtlas ID |
PRKAB2 |
| HGNC ID |
HGNC:9379 |
| HPRD ID |
04117 |
| IUPHAR ID |
Not Available |
| Guide to Pharmacology ID |
Not Available |
| Chromosome Location |
Not Available |
| Locus |
1q21.1 |
| SNPs |
PRKAB2 |
| General References |
- Thornton C, Snowden MA, Carling D: Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. J Biol Chem. 1998 May 15;273(20):12443-50. Pubmed
- Prochazka M, Farook VS, Ossowski V, Wolford JK, Bogardus C: Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians. Mol Cell Probes. 2002 Dec;16(6):421-7. Pubmed
|
| Drugs |
| # |
DrugBank ID |
Drug Name |
Drug Type |
Drug Groups |
| 1 |
DB00131 |
Adenosine monophosphate |
small molecule |
approved, nutraceutical |
|
